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    Wyświetlanie 1-2 z 2
    Tytuł:
    Enzymatic antioxidant defense in isolated rat hepatocytes exposed to cadmium
    Autorzy:
    Skrzycki, M.
    Czeczot, H.
    Majewska, M.
    Podsiad, M.
    Karlik, W.
    Grono, D.
    Wiechetek, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/30152.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    antioxidative enzyme
    rat
    hepatocyte
    cadmium exposure
    oxidative stress
    lipid peroxidation
    reduced glutathione
    glutathione
    environment contaminant
    animal health
    superoxide dismutase
    catalase
    glutathione peroxidase
    glutathione transferase
    glutathione reductase
    Opis:
    The aim of the study was the evaluation of cadmium effects on the activity of antioxidant enzymes in rat hepatocytes. The studies were conducted with isolated rat hepatocytes incubated for 1 or 2 hours in a modified (deprived of carbonates with phosphates) Williams’ E medium (MWE) in the presence of cadmium chloride (25, 50 and 200 μM). Hepatocytes incubated in the MWE medium without cadmium chloride were used as a control. The application of the modified Williams’ E medium allowed for the appearance of cadmium compounds in a soluble form that is indispensable for suitable estimation of its toxic action. There were evaluated markers of the oxidative stress such as: concentration of thiobarbiturate reactive substances (TBARS) – proportional to the level of lipid peroxidation, concentration of reduced glutathione (GSH), and the activity of antioxidant enzymes, including superoxide dismutase (SOD1 and SOD2), catalase (CAT), total glutathione peroxidase (GSHPx), selenium – dependent glutathione peroxidase (SeGSHPx), glutathione transferase (GST) and glutathione reductase (GSHR). Alterations of antioxidant enzymes activity, the level of TBARS and GSH in isolated rat hepatocytes caused by cadmium in vitro, were shown to depend on the concentration and time of exposure of cells to this metal. The increased level of TBARS and GSH was observed as well as changes in the activity of antioxidant enzymes. The activity of SOD isoenzymes and CAT was increased, whereas GSHPx and GST were decreased. These results indicate that cadmium induces oxidative stress followed by alterations in the cellular antioxidant enzyme system in isolated rat hepatocytes.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Intraoperative Impedance Measurements for the Evaluation of Perimodiolar Location οf Cochlear Implant Electrode - Own Experience
    Autorzy:
    Stieler, O.
    Karlik, M.
    Szyfter, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1537554.pdf
    Data publikacji:
    2010-07
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    43.90.+v
    43.58.-e
    43.60.-c
    43.60.+d
    Opis:
    Evaluation of insertion of a cochlear implant electrode into the cochlea includes radiological techniques: plain X-ray of the skull, cochlear projection (based on Stenvers projection), computer tomography. These methods allow generally postoperative evaluation. During surgery the insertion of the electrode is assessed based on anatomical structures and markers placed on the electrode. The measurement of the electrode impedance is also an important tool. 60 patients implanted with the Contour cochlear implant with pre-shaped electrode were examined. Age o patients: mediana 4.25 (1.5-54.5). Examination includes intraoperative impedance measurement performed in two stages: (1) after the electrode insertion, and (2) after removal of the stylet. Measurements were done in Common Ground (CG) and Monopolar 1 (MP1) stimulation modes. Measurements recorded in two modes and in 3 different parts of the cochlea (apical, middle, basal) were compared. The average difference value (before-after) was for the CG mode: 0.45 kΩ, and for the MP1 mode: 0.39 kΩ. For the CG mode the difference values were: 0.64, 0.44 and 0.28 toward apical part. For the MP1 mode the difference values were: 0.47, 0.43 and 0.27 toward apical part of the cochlea.
    Źródło:
    Acta Physica Polonica A; 2010, 118, 1; 161-163
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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