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Wyszukujesz frazę "Karimian, A." wg kryterium: Autor


Wyświetlanie 1-7 z 7
Tytuł:
Assessment of the staff absorbed dose related to cyclotron operation and service in the production of 18F radiopharmaceuticals
Autorzy:
Sadat-Eshkevar, S. M.
Karimian, A.
Mirzaii, M.
Powiązania:
https://bibliotekanauki.pl/articles/146607.pdf
Data publikacji:
2012
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
staff dosimetry
Monte Carlo (MC) simulation
18F production
cyclotron
induced radioactivity
liquid target
Opis:
Cyclotron accelerators are used to produce medical radioisotopes. One of the most important problems which may be encountered is malfunction of a part of the target or beam line which requires stopping of the bombardment and making a repair. The decision about doing the repair depends on the whole body dose rate in a target room. In this work, dosimetric conditions related to the production of 18FDG radiopharmaceutical were simulated by the Monte Carlo (MC) method. Independently, the dose rates were measured by 7 ICRU spherical body phantoms placed inside the liquid target room and the maze of the cyclotron. The radiation dose rate inside the target room depends on the duration of the bombardment and the time passed after stopping the bombardment. The correlation between duration of the bombardment and required time after stopping the bombardment to reach the absorbed dose rate less than 25 mi Sv/h, was calculated for the presence and absence of the irradiated target. The results showed that the repair can be started immediately after stopping of the proton bombardment only if the target has been ejected from the target room and the duration of bombardment has not taken more than 10 min.
Źródło:
Nukleonika; 2012, 57, 3; 407-410
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Effect of Bright Light on Physiological Circadian Rhythms and Subjective Alertness of Shift Work Nurses in Iran
Autorzy:
Kakooei, H.
Ardakani, Z. Z.
Ayattollahi, M. T.
Karimian, M.
Saraji, G. B.
Owji, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/90524.pdf
Data publikacji:
2010
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
circadian rhythms
shift work
nurse
bright light
alertness
melatonin
cortisol
body temperature
Opis:
In this study, the effects of bright light (BL) on the rhythms in body temperature, plasma melatonin, plasma cortisol and subjective alertness, in 34 shift work nurses at a university hospital were assessed. They were exposed to very BL (4 500 lx) during 2 breaks (21:15–22:00 and 3:15–4:00) or dim light (300 lx). The subjects were studied under 24 h of realistic conditions during which their plasma cortisol and melatonin were measured at 3-h intervals; their body temperature was also measured during and after night shift work. Subjective alertness was evaluated with the Karolinska sleepiness scale. Administration of BL significantly suppressed night-time melatonin levels. A one-way ANOVA revealed that BL tended to increase cortisol levels and body temperature and significantly improved alertness. These results demonstrate that photic stimulation in a hospital setting can have a powerful influence on the adjustment of the circadian system.
Źródło:
International Journal of Occupational Safety and Ergonomics; 2010, 16, 4; 477-485
1080-3548
Pojawia się w:
International Journal of Occupational Safety and Ergonomics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary design and simulation of a spherical brain PET system (SBPET) with liquid xenon as scintillator
Autorzy:
Moghaddam, N. M.
Karimian, A.
Mostajaboddavati, S. M.
Vondervoort, E.
Sossi, V.
Powiązania:
https://bibliotekanauki.pl/articles/146444.pdf
Data publikacji:
2009
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
positron emission tomography (PET)
Monte Carlo simulation
GATE
liquid xenon
brain imaging
Opis:
Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
Źródło:
Nukleonika; 2009, 54, 1; 33-38
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of a new scintillation crystal (LaBr3) in PET scanners using Monte Carlo method
Autorzy:
Karimian, A. E.
Thompson, Ch. J.
Powiązania:
https://bibliotekanauki.pl/articles/146815.pdf
Data publikacji:
2008
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
PET
scintillation crystals
Monte Carlo
lanthanum bromide
Opis:
The main aim of this work is to investigate the use of new lanthanum bromide (LaBr3) in whole body PET (WB-PET) scanners and to compare the obtained results with those for BGO and LSO crystals which are currently used in conventional and dedicated PET systems. Our results show that there is a gain in noise effective count rate (NECR) arising from the reduced scatter and random fractions in a LaBr3 scanner. The spatial resolution of the WB-PET with LaBr3 is slightly worse than the LSO and BGO crystals because of its low density and effective atomic number. But our study showed the increased NECR, excellent energy resolution and low decay time of LaBr3 which promise a significant improvement in WB-PET performances especially for narrow coincidence windows.
Źródło:
Nukleonika; 2008, 53, 1; 5-6
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and biodistribution of [201Tl](III)vancomycin complex in normal rats
Autorzy:
Jalilian, A.
Hosseini, M.
Karimian, A.
Saddadi, F.
Sadeghi, M.
Powiązania:
https://bibliotekanauki.pl/articles/146167.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
thallium-201
vancomycin
labeling
SPECT
radiopharmaceuticals
infection
Opis:
Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 š 1% by RTLC. A specific activity of about 4.14 x 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.
Źródło:
Nukleonika; 2006, 51, 4; 203-208
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies
Autorzy:
Rowshanfarzad, P.
Jalilian, A.
Kiyomarsi, M.
Sabet, M.
Karimian, A.
Moradkhani, S.
Mirzaii, M.
Powiązania:
https://bibliotekanauki.pl/articles/146165.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
rubidium-82m
quality control
animal study
cyclotron
Opis:
Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.
Źródło:
Nukleonika; 2006, 51, 4; 209-215
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of 62Zn bleomycin as a possible PET tracer
Autorzy:
Jalilian, A.
Fateh, B.
Ghergherehchi, M.
Karimian, A.
Moradkhani, S.
Kamali-Dehghan, M.
Tabeie, F.
Powiązania:
https://bibliotekanauki.pl/articles/148678.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
PET
pharmacokinetics
biodistribution
62Zn
bleomycin
Opis:
Abstract Bleomycin (BLM), labeled with radioisotopes, is widely used in therapy and diagnosis. In this study, BLM was labeled with 62Zn for oncologic PET studies. The complex was obtained at pH = 2 in saline at 90°C in 25 min. Radio-TLC showed an overall radiochemical yield of 95 97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Preliminary in vivo studies were performed to determine complex stability and distribution of 62Zn BLM in normal and fibrosarcoma-bearing mice. 62Zn BLM accumulated significantly in induced fibrosarcoma tumors in mice according to biodistribution/imaging studies. 62Zn BLM can be used in PET oncology studies due to its suitable physicochemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in larger mammals.
Źródło:
Nukleonika; 2005, 50, 4; 143-148
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-7 z 7

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