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    Wyświetlanie 1-3 z 3
    Tytuł:
    Melkersson-Rosenthal syndrome in a patient with Hashimoto disease
    Autorzy:
    Frąckowiak, L.
    Wroński, K.
    Kańczuga-Koda, L.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1914054.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Melkersson-Rosenthal syndrome
    cheilitis granulomatosa
    Hashimoto disease
    autoimmune thyroiditis
    facial nerve palsy
    Opis:
    Introduction: Melkersson-Rosenthal syndrome (MRS) is a rare neurologic disease of unknown etiology. It is characterized by a triad of symptoms: relapsing peripheral facial paralysis; orofacial edema and fissured tongue. The pathological findings are varied but often characterized by the presence of noncaseating granuloma. There are few cases of MRS coexistent with Hashimoto disease in the literature. Purpose: To present a case of MRS coexistent with Hashimoto disease. Case presentation: We report a case of a 32-year-old woman with coexisting MRS and autoimmune thyroiditis, Hashimoto disease. Fissured tongue and recurrent cheilitis of the upper lip were observed. In her medical history, she had facial nerve palsy. Histopathological examination of the upper lips mucose membrane revealed the presence of granulomas confirming the diagnosis. Conclusions: Cooperation between clinicians and histopathologists is vital in diagnosing MRS. The presence of the anti-TPO antibodies in the case reported here could suggest a correlation between immunological alteration characteristics of autoimmune thyroiditis and MRS.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 269-272
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The oncoprotein HBXIP – its functions and roles in oncogenesis
    Autorzy:
    Grudzinska, M.
    Lomperta, K.
    Jakubowska, K.
    Samocik, P.
    Jarząbek, K.
    Kanczuga-Koda, L.
    Wincewicz, A.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918747.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    HBXIP
    survivin
    oncoprotein
    transcription factor
    Opis:
    Nowadays, Hepatitis B X interacting protein (HBXIP) is an object of scientists’ interest worldwide. It is a protein with significant involvement in the development of malignant tumors like breast or ovarian cancer. One of the most important functions of HBXIP is the regulation of cell proliferation, which is related to the progression of a cell cycle. Many studies provide the growing number of evidence that HBXIP plays various important roles, including the regulation of a cell cycle through complexes with survivin, belonging to the inhibitors of apoptosis and interactions with transcriptional factors like STAT4, SP1, TFIID or E2F1. It also has the influence on the promotion of tumor angiogenesis thanks to the association with VEGF and FGF8. Another important role of HBXIP is a reprogramming of glucose metabolism to conditions favorable to growing cancerous cells due to regulating the activation of SCO2 and PDHA1. Furthermore, it impacts on the complement-dependent cytotoxicity, also, HBXIP affects on lipid metabolism through disturbing of metabolic pathways of FAS. According to recent studies, HBXIP can be used as a prognostic biomarker in many tumors, including cervical cancer, ovarian cancer, and esophageal squamous cell carcinoma thanks to the high expression of this protein noted exclusively in these tumor tissues. What is even more interesting, it significantly correlates with clinical attributes like metastasis to lymph nodes or grading and in some cases can potentially be used as the indicator of prognosis of treatment effectiveness. The paper is review through main functions of HBXIP and its possible applications.
    Źródło:
    Progress in Health Sciences; 2018, 8(2); 215-222
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
    Autorzy:
    Grudzińska, M.
    Jakubowska, K.
    Kańczuga-Koda, L.
    Kisielewski, W.
    Famulski, W.
    Smereczański, N.M.
    Lomperta, K.
    Płoński, M.A.
    Rogoz-Jezierska, N.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918914.pdf
    Data publikacji:
    2020-06-10
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    inflammatory cells
    fibrosis
    Opis:
    Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2020, 10(1); 69-76
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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