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    Wyświetlanie 1-12 z 12
    Tytuł:
    Od wzorów ekspresji genów i motywów regulatorowych do predykcji i modelowania ekspresji genów - wyzwania i nadzieje
    Predicting and modeling gene expression from genomic sequences - hopes and challenges
    Autorzy:
    Dąbrowski, Michał
    Kamińska, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1196817.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Opis:
    Control of eukaryotic transcription involves combinatorial interactions between transcription factors and regulatory sequences in the genome. In addition, chromatin structure and modification states play key roles in the complex control of transcription. The maturation of methods for detecting in vivo protein-DNA interactions on a genome-wide scale, detailed maps of chromatin features and transcription factor localization over entire genomes of eukaryotic cells increases our understanding of the properties and nature of transcriptional regulatory mechanisms. The knowledge gained from large-scale investigations has challenged some conventional concepts of promoter structure and function, and provided valuable insights into the complex gene regulatory mechanisms. Here, we review recent experimental and computational advances that have enabled identification and analysis of regulatory regions on an unprecedented scale, allowing for systematic determination of the transcriptional regulatory networks in eukaryotic cells. Analysis of high-throughput gene expression data together with genomic sequence(s) holds promise of revealing features of cis-regulatory sequences responsible for co-regulation of many genes. This general approach has proved successful in simpler organisms, and recent studies in Metazoa reported features over-represented in groups of genes with particular expression patterns revealing gene regulatory mechanisms.
    Źródło:
    Kosmos; 2009, 58, 1-2; 67-77
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Farmakologiczna modulacja funkcji i żywotności astrocytów jako nowa strategia neuroprotekcji po niedokrwieniu
    Pharmacological modulation of function and viability of astrocytes as a novel neuroprotective strategy in stroke
    Autorzy:
    Szydłowska, Kinga
    Kamińska, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1197456.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Opis:
    Neuron-astrocyte interactions are critical for signalling, energy metabolism, extracellular ion and glutamate homeostasis, volume regulation and neuroprotection in the central nervous system. Glutamate uptake by astrocytes may prevent excitotoxic glutamate elevation and determine neuronal survival. However, activation of astrogliosis and brain inflammation during cerebral ischemia exacerbates primary brain damage, resulting in upregulation of cytotoxic/infammatory cytokines and mediators, that alter blood flow and increase vascular permeability, thus leading to secondary damage and accumulation of immune cells in the brain. Although, astrocytes are more resistant than neurons to ischemic injury, astrocyte death have been demonstrated in animal models of brain ischemia. Exposure of cultured cortical astrocytes to glutamate induces apoptotic cell death and similar events can be detected in ischemic brain. FK506, an inhibitor of calcineurin and immunosuppressive drug, is neuroprotective in animal models of neurologic diseases, including focal and global ischemia. FK506 exerts a complex action on many processes ongoing in pathological brain: it directly protects neurons from glutamate-induced neuronal cell death, reduces gliosis and brain inflammation in animal models of stroke, and inhibits Glu-induced apoptosis of astrocytes in vitro and in ischemic brain. Altogether, recent findings suggest that modulation of astrocyte functions and astrocytic survival/cell death in neurodegeneration may be a novel therapeutic strategy in neurological disorders.
    Źródło:
    Kosmos; 2008, 57, 3-4; 315-329
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli
    Autorzy:
    Wisniewski, Pawel
    Master, Adam
    Kaminska, Bozena
    Powiązania:
    https://bibliotekanauki.pl/articles/1040813.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Fas ligand
    interfering molecules
    recombinant protein purification
    Fas
    apoptosis
    Opis:
    This report presents purification and characterization of the extracellular domain of rat Fas protein, called FIP (FasL interfering protein), expressed as inclusion bodies in Escherichia coli. FIP was extracted from the inclusion bodies, solubilized with 8 M urea, purified by a single-step immobilized metal ion (Ni2+) affinity chromatography and refolded. SDS/PAGE and mass spectrometry analysis of the purified protein verified its purity. Fluorescence spectrum analysis showed that the refolding procedure caused structural changes which presumably might have led to oligomerization. The purified FIP has biological activities: it binds specifically soluble Fas ligand and protects human Jurkat lymphocytes against FasL-dependent apoptosis. This efficient procedure of FIP expression in E. coli and renaturation may be useful for production of therapeutically important proteins.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 51-56
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    TGF beta signalling and its role in tumour pathogenesis.
    Autorzy:
    Kaminska, Bozena
    Wesolowska, Aleksandra
    Danilkiewicz, Malgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041410.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Smad propteins
    RNA interference.
    TGF beta signal transduction
    tumour invasion
    cancer therapy
    MAP kinases
    Opis:
    Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in the regulation of cell proliferation, differentiation and survival/or apoptosis of many cells. Knock-out experiments in mice for the three isoforms of TGF-β have demonstrated their importance in regulating inflammation and tissue repair. TGF-β is implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis. TGF-β receptors act through multiple intracellular pathways. Upon binding of TGF-β with its receptor, receptor-regulated Smad2/3 proteins become phosphorylated and associate with Smad4. Such complex translocates to the nucleus, binds to DNA and regulates transcription of specific genes. Negative regulation of TGF-β/Smad signalling may occur through the inhibitory Smad6/7. Furthermore, TGF-β-activated kinase-1 (TAK1) is a component of TGF-β signalling and activates stress-activated kinases: p38 through MKK6 or MKK3 and c-Jun N-terminal kinases (JNKs) via MKK4. In the brain TGF-β, normally expressed at the very low level, increases dramatically after injury. Increased mRNA levels of the three TGF-β isoforms correlate with the degree of malignancy of human gliomas. TGF-βs are secreted as latent precursors requiring activation into the mature form. TGF-β may contribute to tumour pathogenesis by direct support of tumour growth and influence on local microenvironment, resulting in immunosuppression, induction of angiogenesis, and modification of the extracellular matrix. TGF-β1,2 may stimulate production of vascular endothelial growth factor (VEGF) as well as plasminogen activator inhibitor (PAI-I), that are involved in vascular remodelling occurring during angiogenesis. Blocking of TGF-β action inhibits tumour viability, migration, metastases in mammary cancer, melanoma and prostate cancer model. Reduction of TGF-β production and activity may be a promising target of therapeutic strategies to control tumour growth.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 329-337
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kainate-evoked modulation of gene expression in rat brain
    Autorzy:
    Kaminska, Bożena
    Filipkowski, Robert
    Biedermann, Ireneusz
    Konopka, Dorota
    Nowicka, Dorota
    Hetman, Michał
    Dąbrowski, Michał
    Gorecki, Dariusz
    Lukasiuk, Katarzyna
    Szklarczyk, Arkadiusz
    Kaczmarek, Leszek
    Powiązania:
    https://bibliotekanauki.pl/articles/1044905.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1997, 44, 4; 781-789
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neuroprotective role of some microelements in the course of neurodegenerative diseases
    Autorzy:
    Witek, Bożena
    Kamińska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/472596.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
    Tematy:
    homeostasis,
    microelements,
    neurodegenerative diseases
    Źródło:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2019, IX; 5-12
    2083-7267
    2450-3487
    Pojawia się w:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    What next for diabetes mellitus?
    Autorzy:
    Witek, Bożena
    Rochon-Szmejchel, Danuta
    Kamińska, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/472510.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
    Tematy:
    diabetes
    insulin
    glucagon
    Źródło:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 6-19
    2083-7267
    2450-3487
    Pojawia się w:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of tire pressure on fuel consumption in trucks with installed tire pressure monitoring system (TPMS)
    Autorzy:
    Szczucka-Lasota, Bożena
    Kamińska, Joanna
    Krzyżewska, Iwona
    Powiązania:
    https://bibliotekanauki.pl/articles/198221.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    tire
    pressure
    monitoring
    TPMS
    fuel consumption
    opona
    ciśnienie
    zużycie paliwa
    Opis:
    In recent years, the development of IT systems for fleet monitoring was observed. Tire pressure monitoring systems are constantly improved. Decreased values in tire pressure can cause deformation of tires. Monitoring of tire pressure is an important function in oversized transport trucks. Tire pressure and rolling resistant influence fuel consumption. The purpose of this paper was to determine the impact of tire pressure on fuel consumption in a fleet of trucks with tire pressure monitoring system installed and to determine the impact of other factors that may affect fuel consumption, such as the vehicle weight, brake usage and cruise control usage. The results of the research were developed using a multiple regression model describing the above dependence.
    Źródło:
    Zeszyty Naukowe. Transport / Politechnika Śląska; 2019, 103; 167-181
    0209-3324
    2450-1549
    Pojawia się w:
    Zeszyty Naukowe. Transport / Politechnika Śląska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Primary and secondary prevention of breast cancer
    Autorzy:
    Kolak, Agnieszka
    Kamińska, Marzena
    Sygit, Katarzyna
    Budny, Agnieszka
    Surdyka, Dariusz
    Kukiełka-Budny, Bożena
    Burdan, Franciszek
    Powiązania:
    https://bibliotekanauki.pl/articles/987031.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    breast cancer
    primary and secondary prevention
    risk factors
    life style
    mammography
    modern diagnostics methods
    Opis:
    Introduction. Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. There is much evidence showing the influence of life style and environmental factors on the development of mammary gland cancer (high-fat diet, alcohol consumption, lack of physical exercise), the elimination of which (primary prevention) may contribute to a decrease in morbidity and mortality. Secondary prevention, comprising diagnostic tests (e.g. mammography, ultrasonography, magnetic resonance imaging, breast self-examination, as well as modern and more precise imaging methods) help the early detection of tumours or lesions predisposing to tumours. Objective. The aim of this study paper is to review current knowledge and reports regarding primary and secondary prevention of breast cancer. State of knowledge. It is estimated that nearly 70% of malign tumours are caused by environmental factors, whereas in breast cancer this percentage reaches 90–95%. There are national programmes established in many countries to fight cancer, where both types of prevention are stressed as serving to decrease morbidity and mortality due to cancers. Conclusions. Cancer prevention is currently playing a key role in the fight against the disease. Behaviour modification, as well as greater awareness among women regarding breast cancer, may significantly contribute towards reducing the incidence of this cancer. Another important aspect is the number of women undergoing diagnostic tests, which still remains at an unsatisfactory level.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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