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    Wyświetlanie 1-3 z 3
    Tytuł:
    Haemocytometric profile and plasma levels of selected cytokines in patients at various stages of cervical cancer
    Autorzy:
    Alani Jimoh, Mutiu
    Adekunle Onifade, Abdulfatah
    Mpakaboari Abbiyesuku, Fayeofori
    Fabian Edem, Victory
    Kadiri Rahamon, Sheu
    Ganiyu Arinola, Olatunbosun
    Powiązania:
    https://bibliotekanauki.pl/articles/29520454.pdf
    Data publikacji:
    2023-12-31
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cancer stage
    cervical cancer
    haemocytometry
    interleukin-6
    parity
    Opis:
    Introduction and aim. Reports have shown that there is alteration in haematological and inflammatory processes in patients with cervical cancer. However, there is the dearth of information on the pattern of alteration in Nigerian patients with cervical cancer at various stages of the disease. Therefore, haemocytometric profile and plasma levels of interleukin-6 (IL-6) and IL-12 were determined in Nigerian patients with cervical cancer at various stages of the disease. Material and methods. Eighty-nine adults consisting of 49 patients with cervical cancer and 40 apparently healthy controls were enrolled into this study. Haemocytometric profile was determined using automated haematology analyzer while the plasma levels of interleukin-6 (IL-6) and IL-12 were determined using ELISA. Results. Of the participants with cervical cancer, 6.12%, 24.49%, 53.06% and 16.33% were in stages I, II, III and IV respectively. The mean plasma IL-6 level was significantly higher in patients at stage IV of the cancer compared with those in stages I, II and III. No significant differences were observed in the mean plasma IL-12 level, and the haemocytometric profile when patients in different stages of the cancer were compared with one another. Plasma IL-6 had significant positive correlation with the lymphocytes count and cancer stage but had significant negative correlation with packed cell volume (PCV), haemoglobin and total white blood cells count (WBC) in patients with cervical cancer. Conclusion. Interleukin-6 appears to play an important role in the progression of cervical cancer and could be involved in cervical cancer-associated alteration in haemocytometric profile.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 4; 696-703
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in haematological parameters and serum beta-2-microglobulin levels in CD4+ T-cells-stratified Nigerian HIV patients
    Autorzy:
    Ayodele Olaniyi, John
    Joseph Emeka, Godwin
    Adekunle Onifade, Abdulfatah
    Olusoji Adeyanju, Alaruru
    Kadiri Rahamon, Sheu
    Powiązania:
    https://bibliotekanauki.pl/articles/2040249.pdf
    Data publikacji:
    2021-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    beta-2-microglobulin
    CD4+ T-cells count
    haemocytometry
    HIV
    lymphopaenia
    Opis:
    Introduction. Reports have shown that there is a rise in beta-2-microglobulin (β2M) concentration in patients with HIV infection and that the degree of elevation correlates well with the extent of disease burden and could be an independent prognostic marker for death. However, there is the dearth of information on the interplay between alteration in haematological profile, a common cause of morbidity and mortality in HIV, and β2M. Aim. Changes in selected haematological parameters and β2M in Nigerian HIV patients stratified based on CD4+ T-cells counts were thus assessed in this study. Material and methods. Forty-eight asymptomatic, drug naïve HIV patients were enrolled into this cross-sectional study. Haemoglobin concentration (Hb), packed cell volume (PCV), total and differential white blood cell count, platelet count and CD4+ T-cells count were determined using standard methods while serum levels of β2M were determined using ELISA. Thereafter, the patients were stratified into three groups based on the CD4+ T-cells count. Results. Hb and lymphocyte counts increased with increasing CD4+ T-cells count. In contrast, neutrophils percentage, MCV and MCH reduced with increasing CD4+ T-cells count. The mean lymphocytes percentage was significantly higher while the mean neutrophils percentage was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with the patients with CD4+ T-cells count <200 cells/μl. Similarly, the mean MCV was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with patients with CD4+ T-cells count of 200–499 cells/μl and patients with CD4+ T-cells count <200 cells/μl. β2M had significant positive correlation with WBC and neutrophils percentage but had a significant negative correlation with lymphocytes percentage and MCH in patients with CD4+ T-cells count <200 cells/μl. However, β2M had sig nificant positive correlation with PCV, Hb, monocytes and morphology in patients with CD4+ T-cells count of 500–800 cells/μl. Conclusion. It could be concluded from this study that HIV infection is associated with alteration in haematological profile and the alteration is CD4+ T-cells count-dependent. Also, elevation in β2M concentration appears to be a marker of lymphopaenia in patients with low CD4+ T-cells count
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 1; 33-39
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome
    Autorzy:
    Rahamon, Sheu Kadiri
    Arinola, Olatunbosun Ganiyu
    Charles-Davies, Mabel Ayebatonyo
    Akinlade, Kehinde Sola
    Olaniyi, John Ayodele
    Fasanmade, Adesoji Adedipe
    Oyewole, Oyediran Emmanuel
    Owolabi, Mayowa Ojo
    Adebusuyi, Jane Roli
    Hassan, Olufunke Olayemi
    Ajobo, Muhammed Babatunde
    Adigun, Kehinde
    Ebesunun, Maria Onomaghuan
    Popoola, Omolara Olutosin
    Omiyale, Wemimo
    Agbedana, Emmanuel Oluyemi
    Powiązania:
    https://bibliotekanauki.pl/articles/2040233.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    metabolic syndrome
    vitamin D
    inflammation
    Opis:
    Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 306-312
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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