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Tytuł:
Application of machine learning and rough set theory in lean maintenance decision support system development
Autorzy:
Antosz, Katarzyna
Jasiulewicz-Kaczmarek, Małgorzata
Paśko, Łukasz
Zhang, Chao
Wang, Shaoping
Powiązania:
https://bibliotekanauki.pl/articles/2038009.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
lean maintenance
availability
machine learning
decision trees
rough set theory
Opis:
Lean maintenance concept is crucial to increase the reliability and availability of maintenance equipment in the manufacturing companies. Due the elimination of losses in maintenance processes this concept reduce the number of unplanned downtime and unexpected failures, simultaneously influence a company’s operational and economic performance. Despite the widespread use of lean maintenance, there is no structured approach to support the choice of methods and tools used for the maintenance function improvement. Therefore, in this paper by using machine learning methods and rough set theory a new approach was proposed. This approach supports the decision makers in the selection of methods and tools for the effective implementation of Lean Maintenance.
Źródło:
Eksploatacja i Niezawodność; 2021, 23, 4; 695-708
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of Principle Component Analysis and logistic regression to support Six Sigma implementation in maintenance
Autorzy:
Antosz, Katarzyna
Jasiulewicz-Kaczmarek, Małgorzata
Machado, Jose
Relich, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/28328274.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
maintenance management
Six Sigma generation
DMAIC
PCA
logistic regression
Opis:
Improving the efficiency of maintenance processes is one of the goals of companies. Improvement activities in this area require not only an appropriate maintenance strategy but also the use of a new approach to increase the efficiency of the process. This article focuses on using Six Sigma (SS) to improve maintenance processes. As an introduction, the generations of SS development are identified, and traditional and advanced analytical tools that can be useful in SS projects are reviewed. As part of the research, an example of the implementation of the SS project in the maintenance process using the DMAIC and selected advanced analytical methods, such as PCA and logistic regression, was presented. The PCA results showed that it was enough to have seven main components to keep about 84% of the information on variability. In developed logistic regression explained the impact of the individual factors affecting the availability of the machines. The identified factors and their interactions made it possible to define maintenance activities requiring improvements
Źródło:
Eksploatacja i Niezawodność; 2023, 25, 4; art. no. 174603
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacterially expressed truncated F2 domain of Plasmodium falciparum EBA-140 antigen can bind to human erythrocytes
Autorzy:
Rydzak, Joanna
Kryńska, Katarzyna
Suchanowska, Anna
Kaczmarek, Radosław
Łukasiewicz, Jolanta
Czerwiński, Marcin
Jaśkiewicz, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1039687.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
truncated F2 domain purification
human erythrocyte binding
EBA-140 antigen
Plasmodium falciparum
recombinant F2 domain expression
Opis:
The recently identified erythrocyte binding antigen-140 (EBA-140) is a member of the Plasmodium falciparum DBL family of erythrocyte binding proteins, which are considered as prospective candidates for malaria vaccine development. The EBA-140 ligand is a paralogue of the well-characterized P. falciparum EBA-175 antigen. They share homology of domain structure, including Region II, which consists of two homologous F1 and F2 domains and is responsible for ligand-erythrocyte interaction during invasion. It was shown that the F2 domain of EBA-175 antigen seems to be more important for erythrocyte binding. In order to study activity and immunogenicity of EBA-140 antigen F2 domain, it is necessary to obtain recombinant protein of high purity and in a sufficient amount, which used to pose a challenge due to the high content of disulphide bridges. Here, we present a new method for expression and purification of Plasmodium falciparum EBA-140 antigen F2 domain in E. coli Rosetta-gami strain in fusion with the maltose binding protein (MBP). The truncated F2 domain formed by spontaneous proteolytic degradation of the fusion protein was purified by affinity chromatography on Ni-NTA resin followed by size exclusion chromatography. Molecular mass of this protein was confirmed by mass spectrometry. Its N-terminal amino acid sequencing revealed a proteolytic cleavage site within the F2 domain. The proper folding of the recombinant, truncated F2 domain of EBA-140 antigen was confirmed by circular dichroism analysis. The truncated F2 domain can specifically bind to human erythrocytes but its binding is not as efficient as that of full Region II. This confirms that both the F1 and F2 domains of EBA-140 antigen are required for effective erythrocyte binding.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 685-691
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Band keratopathy - chelation or therapeutic photokeratectomy
Autorzy:
Alsoubie, Ismael
Pyza, Aneta
Kaczmarek, Julia
Czarnacka, Kinga
Prokop, Dominika
Kuźlik, Bartosz
Chmura, Alicja
Pandey, Ada
Gawlak, Małgorzata
Żaczek, Bartłomiej
Sajak-Hydzik, Katarzyna
Pawlicka, Ilona
Piskorz, Agnieszka
Kozak, Maciej
Roszkowska, Anna Maria
Powiązania:
https://bibliotekanauki.pl/articles/23202547.pdf
Data publikacji:
2023-09-30
Wydawca:
Medical Education
Tematy:
band keratopathy
calcium deposits
EDTA chelation
phototherapeutic keratectomy
excimer laser
corneal degeneration
ethylenediaminetetraacetic acid
Opis:
Corneal degeneration changes corneal shape and causing its translucency disappear. The division of corneal degeneration is made according to the type deposited in its layer. Among the factors causing keratopathy, the following can be mentioned: iron, collagen, hemosiderins, and calcium salts, the last ones cause band keratopathy. This feature is characteristic of the deposition of opacities in the superficial layers of the cornea. In the treatment of band keratopathy, ethylenediaminetetraacetic acid chelation and excimer laser phototherapeutic keratectomy are discussed.
Źródło:
OphthaTherapy; 2023, 10, 3; 195-199
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biodegradable polymer coatings on Ti6Al7Nb alloy
Autorzy:
Szewczenko, Janusz
Kajzer, Wojciech
Kajzer, Anita
Basiaga, Marcin
Kaczmarek, Marcin
Antonowicz, Magdalena
Nowińska, Katarzyna
Jaworska, Joanna
Jelonek, Katarzyna
Kasperczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/306476.pdf
Data publikacji:
2019
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Ti6Al7Nb
powłoka polimerowa
zwilżalność
odporność na korozję
uwalnianie jonów
przyczepność
biodegradable polymer coating
wettability
corrosion resistance
ion release
adhesion of polymer coatings
Opis:
The aim of the study was to determine the influence of long term exposure to Ringer’s solution of biodegradable polymer coatings containing an active substance on the Ti6Al7Nb alloy substrate on the physical and chemical properties of the coatings and the degradation process of the metal substrate. The studies used poly(L-lactide-co-trimethylene carbonate) P(L/TMC), poly(L-lactide-co-trimethylene carbonate-glycolide) P(L/TMC/G) and poly(D,L-lactide-glycolide) (PLGA) coatings applied to the anodically oxidized Ti6Al7Nb alloy by means of dipping method (1, 2 and 3 dips). The polymer coatings contained ciprofloxacin. Roughness and wettability tests were carried out on the substrate and polymer coatings, the pitting corrosion resistance of the substrate and samples with polymer coating was determined, the number of metallic ions released to the solution from the coated and uncoated samples was determined as well as the adhesion of polymer coatings. The research was supplemented by microscopic observations. The results of the research indicate different influence of exposure to Ringer’s solution on the physical and chemical properties of biodegradable polymer coatings containing ciprofloxacin and the course of the degradation process of the metal substrate.
Źródło:
Acta of Bioengineering and Biomechanics; 2019, 21, 4; 83-92
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cechy osobowości a decyzje adolescentów dotyczące planów edukacyjnych i zawodowych
Autorzy:
Markiewicz, Katarzyna
Kaczmarek, Bożydar L.J.
Kostka-Szymańska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/637069.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
adolescence, career planning, personality traits, economic changes
Opis:
Personality traits and adolescents’ decisions concerning education and career planningOne of the most signifi cant tasks confronting adolescents is planning future career in order to start an independent life (Kanfer et al., 2001). A number of studies show that it poses number of signifi cant problems (Super, 1963; Super, Savickas, Super, 1996; Webber, 1990; Borgen, Amundson, 2010). The aim of the present study was to defi ne decision-making mechanisms that have an impact on career planning by adolescents and the infl uence of their personality traits upon it. The NEO-FFI Inventory and a self-constructed questionnaire were administered to 116 students of the last year of a secondary school. The data indicate correlations between the choices concerning further studies and personality traits measured with NEO-FFI Inventory. The following traits proved to be signifi cant: neuroticism, extraversion, agreeableness, and conscientiousness
Źródło:
Psychologia Rozwojowa; 2010, 15, 3
1895-6297
2084-3879
Pojawia się w:
Psychologia Rozwojowa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterisation of chitosan after cross-linking by tannic acid
Autorzy:
Sionkowska, Alina
Kaczmarek, Beata
Lewandowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035183.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
cross-linking
mechanical properties
tannic acid
Opis:
Chitosan is widely applied in biomedical and cosmetic fields. For this reason, there is a need to modify this biopolymer to achieve new properties of chitosan-based materials. The properties of chitosan can be modified by several cross-linking methods. In this work, we used the chemical cross-linking of chitosan with tannic acid, after which cross-linked chitosan was shaped into a 3D structure by the lyophilisation process. For the material obtained, FTIR-ATR analysis was performed to characterise the structure of cross-linked chitosan. Moreover, mechanical properties and swelling properties were measured for chitosan before and after cross-linking. The results show that several properties of chitosan can be changed after cross-linking by tannic acid. The positions of bands in the FTIR spectra of chitosan were shifted after cross-linking. Mechanical properties were altered for cross-linked chitosan. However, the highest compressive modulus was observed for pure chitosan. The lowest compressive modulus was observed for chitosan cross-linked with 20 wt% of tannic acid. Swelling behaviour also depends on the cross-linking of chitosan. It decreases for chitosan after cross-linking by tannic acid. Overall, the properties of cross-linked chitosan depend on the amount of tannic acid used for modification. This method of cross-linking can be useful for obtaining materials with specific properties.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 135-138
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cognitive dysfunctions in a Minimally Verbal (MV) patient with Autism Spectrum Disorder (ASD)
Autorzy:
Markiewicz, Katarzyna
Kaczmarek, Bożydar L.J
Kropotov, Juri D
MacQueen, Weronika D
MacQueen, Bruce D
Pachalska, Maria
Powiązania:
https://bibliotekanauki.pl/articles/2106145.pdf
Data publikacji:
2019-11-22
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
intellectual disability
epilepsy
event related potentials
EEG
QEEG
Opis:
The aim of this study was to examine the neurophysiological correlates of cognitive dysfunctions in a patient with the minimally verbal variant of Autism Spectrum Disorder (ASD + MV), who after reaching adulthood showed progressive deterioration of his cognitive skills. The patient was a 25-year-old male, diagnosed with ASD. He never developed spoken language, and communicated only by gesturing or writing on a computer. Our findings confirmed comorbidity of ASD and epilepsy, accompanied by dysfunction of cognitive control. We also found that spontaneous EEG and event-related potentials (ERPs) in a cued GO/NOGO task can be used to assess functional brain changes concomitant with ASD.
Źródło:
Acta Neuropsychologica; 2019, 17(3); 301-310
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of drugs belonging to the group of ophthalmic non-steroidal anti-inflammatory drugs
Autorzy:
Chmura-Hołyst, Alicja
Czarnacka, Kinga
Żaczek, Bartłomiej
Pandey, Ada
Prokop, Dominika
Gawlak, Małgorzata
Kuźlik, Bartosz
Alsoubie, Ismael
Pyza, Aneta
Kaczmarek, Julia
Sajak-Hydzik, Katarzyna
Pawlicka, Ilona
Piskorz, Agnieszka
Kozak, Maciej
Roszkowska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/51789547.pdf
Data publikacji:
2023-12-31
Wydawca:
Medical Education
Tematy:
non-steroidal anti-inflammatory drugs
diclofenac
ketorolac
bromfenac
nepafenac
Opis:
Ophthalmic non-steroidal anti-inflammatory drugs are non-steroidal anti-inflammatory drugs used to treat or prevent eye inflammation. Their main action is to relieve symptoms such as pain, redness and swelling that can be caused by eye diseases, injuries or eye surgery. Non-steroidal anti-inflammatory drugs used in ophthalmology include substances such as diclofenac, ketorolac, bromfenac and nepafenac. So far, many studies have been published comparing the effectiveness of various systemic and local non-steroidal anti-inflammatory drugs. This work contains a comparative analysis of the above-mentioned substances in terms of their use and effectiveness in ophthalmology.
Źródło:
OphthaTherapy; 2023, 10, 4; 277-282
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coping Strategies and COVID-19 Prevalence Among University Students Learning in the Online and Blended Mode
Autorzy:
Markiewicz, Katarzyna
Kaczmarek, Bożydar L.J.
Oryshchyn-Buzhdyhan, Lidiya
Powiązania:
https://bibliotekanauki.pl/articles/2057076.pdf
Data publikacji:
2022-06-30
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
country
age
gender
personality
executive functions
Opis:
The study assessed whether students who contracted COVID-19 and did not fall ill differed in coping strategies. The study comprised 111 participants, including 55.9% who were infected and 44.1% who were not. It consisted of online (49.5%) and blended mode learners (50.5%) aged 19 to 31. We used the Brief COPE Inventory to assess ways of coping with stress. Among online students, 65.5% fell ill, while less than half of blended mode learners got sick. Students who contracted COVID-19 were more likely to use maladaptive coping strategies, and respondents who did not become ill were more likely to use adaptive strategies.
Źródło:
The New Educational Review; 2022, 68; 223-234
1732-6729
Pojawia się w:
The New Educational Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CURRENT AND TRADITIONAL VIEWS ON THE BRAIN WORKS
Autorzy:
Kaczmarek, Bożydar L.J
Markiewicz, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/2137723.pdf
Data publikacji:
2018-07-22
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
ERPs
neuronal circuits
neuromarkers
neuromodulation
neurofeedback
Opis:
The present paper argues that the development of a new methodology in studying the brain has resulted in a change of our views on the way it works, has seen the emergence of new ideas, and a considerable modification of traditionally accepted theories. The most significant are neuroplasticity, negative activity network (NAT), the nature of aphasic disorders, and the approach to the localization of brain functions. New brain imaging techniques have confirmed also the ability to change the neuronal circuits by mental force. Moreover, new techniques have brought about a rise in new methods for both the diagnosis and rehabilitation of individuals with various brain disorders. Most valuable in this respect has proved to be neurofeedback. We have concentrated on the most important contributions of Prof. Pąchalska in the implementation and development of these new ideas on brain functioning. We also emphasize the fact that her theoretical considerations are firmly based upon her extensive (forty years) work with brain damaged patients.
Źródło:
Acta Neuropsychologica; 2018, 16(2); 201-212
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnostyka postnatalna wad układu moczowego wykrytych w okresie prenatalnym. Część 1. Wady z poszerzeniem dróg moczowych
Postnatal diagnosis of prenatally detected congenital anomalies of the kidney and urinary tract (CAKUT). Part 1. Urinary tract dilatation
Autorzy:
Tkaczyk, Marcin
Czarniak, Piotr
Gastoł, Piotr
Kaczmarek, Piotr
Kiliś-Pstrusińska, Katarzyna
Samolewicz, Emeryk
Warchoł, Stanisław
Żurowska, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1030406.pdf
Data publikacji:
2010
Wydawca:
Medical Communications
Tematy:
neonate
infant
ultrasound diagnostics
urinary tract malformation
guidelines
noworodek
niemowlę
diagnostyka ultrasonograficzna
wady wrodzone układu moczowego
zalecenia
Opis:
Increased availability of prenatal ultrasound examination resulted in high number of early detected abnormalities of urinary tract in neonates and infants. In at least 1/100 normal pregnancies abnormal picture of kidneys or urinary tract is suspected. Most frequently the urinary tract dilatation may be detected. One or both of the kidneys could be affected but dilatation of renal pelvis, ureter or enlargement of urinary bladder may be seen. High percent of abnormalities resolve during infancy and do not constitute an indication for postnatal surgery. On the other hand, enlarged urinary bladder with widened urinary tract accompanied by oligohydramnios clearly indicates serious congenital malformation with high perinatal risk of death. Prenatal evaluation enables both, prenatal intervention and more frequently proper and detailed planning of careful clinical postnatal evaluation. According to Polish regulations the follow up relies mainly on neonatologist and paediatrician. Unfortunately, standards of such care are not available. In the present publication (prepared in multidisciplinary cooperation of urologists, nephrologists and radiologists) we describe a part of guidelines concerning diagnostic procedures with neonates or infants with urinary tract dilatation suggested by prenatal screening. This paper is dedicated to these physicians who deal with postnatal diagnosis of urinary tract malformation. They include scheme for evaluation in case of renal pelvis dilatation, megaureter, posterior urethral valves. Suggestions for antibiotic prophylaxis are also presented.
Szeroka dostępność prenatalnej diagnostyki ultrasonograficznej płodu niesie ze sobą korzyści pod postacią zwiększonej wykrywalności wad wrodzonych układu moczowego. Wadę taką w rutynowym badaniu podejrzewa się mniej więcej u 1/100 płodów. Najczęściej wykrywanym obrazem jest poszerzenie dróg moczowych płodu. Zmiany mogą dotyczyć jednej lub obu nerek płodu. Można zauważyć także poszerzenie moczowodów oraz powiększony pęcherz moczowy. W dużej liczbie przypadków obraz poszerzenia miedniczek nerkowych ustępuje lub nie stanowi ostatecznie wskazań do interwencji zabiegowej. Z drugiej strony powiększenie pęcherza moczowego i dróg moczowych wraz ze skąpowodziem wskazuje na poważną wadę wrodzoną z wysokim ryzykiem okołoporodowym. Obraz prenatalny dróg moczowych nie tylko umożliwia zaplanowanie interwencji w okresie ciąży, ale także pozwala ustalić właściwe postępowanie okołoporodowe, co ze względu na wysoką częstość nieprawidłowych obrazów ułatwia racjonalne postępowanie. W obecnej strukturze opieki zdrowotnej pierwszy etap diagnostyki planowany jest dla lekarzy neonatologów i pediatrów, którzy do tej pory nie mieli dostępu do zunifikowanych zaleceń co do takiego postępowania. Prezentowana praca powstała na podstawie zaleceń Polskiego Towarzystwa Nefrologii Dziecięcej, które przygotował wielodyscyplinarny zespół urologów, nefrologów oraz specjalistów radiologów – pisana była z myślą o lekarzach prowadzących pourodzeniową diagnostykę wad. Zaprezentowano w niej zalecenia dotyczące diagnostyki pourodzeniowej w przypadku poszerzenia miedniczki nerkowej, moczowodu, zastawek cewki tylnej. Zawiera także sugestie co do stosowania profilaktyki zakażeń układu moczowego.
Źródło:
Pediatria i Medycyna Rodzinna; 2010, 6, 2; 118-124
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of NaCl and KCl solutions on deformation of PVA hydrogel – chemo-mechanical coupling
Wpływ roztworów NaCl i KCl na deformację hydrożelu PVA – sprzężenie chemo-mechaniczne
Autorzy:
Kazimierska-Drobny, Katarzyna
Kaczmarek, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/946977.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
hydrogels
PVA
chemo-mechanics
reservoir test
ultrasound
hydrożele
chemo-mechanika
test zbiornikowy
ultradźwięki
Opis:
This paper provides results of studies of chemically induced deformation of PVA [poly(vinyl alcohol)] hydrogels due to interaction with diffusing NaCl and KCl solutions. The experimental studies were carried out in the specially modified reservoir system, where simultaneously registration the changes in the reservoir salt concentration and the deformation under chemical load were applied. The linear model is used to determine the chemo-mechanical coupling parameter. The results showed that PVA hydrogels deform in the presence of salts in pore fluid and the higher the salt concentration the greater deformation is observed.
W pracy przedstawiono wyniki badań chemicznie indukowanej deformacji w hydrożelach poli(alkoholu winylowego) (PVA) pod wpływem oddziaływania z dyfundującymi roztworami NaCl i KCl. Badania obejmowały specjalnie zmodyfikowany test zbiornikowy, w trakcie którego rejestrowano jednocześnie zmiany stężenia soli w zbiorniku i deformację pod obciążeniem chemicznym. Do wyznaczenia parametrów sprzężenia chemiczno-mechanicznego zastosowano liniowy model chemo-deformacji. Stwierdzono, że hydrożele PVA deformują się w obecności soli w płynie porowym, w stopniu zależnym od stężenia soli.
Źródło:
Polimery; 2020, 65, 1; 44-50
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of p16 in sporadic primary uveal melanoma.
Autorzy:
Lamperska, Katarzyna
Mackiewicz, Krystyna
Kaczmarek, Aldona
Kwiatkowska, Eliza
Starzycka, Maria
Romanowska, Bożena
Heizman, Janina
Stachura, Jerzy
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043765.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
sporadic primary uveal melanoma
mutations
p16 protein
Opis:
Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 377-385
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 37

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