- Tytuł:
- The influence of modification at position 2 on the side-chain conformation in oxytocin analogs
- Autorzy:
-
Śmiech, Bogusław
Kaźmierkiewicz, Rajmund
Lammek, Bernard - Powiązania:
- https://bibliotekanauki.pl/articles/1041276.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
oxytocin analogs
torsional angle distribution
EDMC - Opis:
- The nonapeptide oxytocin (OT) is used in medicine to help begin and/or continue childbirth. Its analogs can be also used to control bleeding following fetus delivery. The main function of oxytocin is to stimulate contraction of uterus smooth muscle and the smooth muscle of mammary glands, thus regulating lactation. This paper describes theoretical simulations of the distribution of the torsional angles χ1 in the non-standard methylated phenylalanine residues of three oxytocin analogs: [(Phe)2o-Me]OT, [(Phe)2m-Me]OT, [(Phe)2p-Me]OT. The conformations of the oxytocin analogs were studied both in vacuum and in solution. We found some correlations between the biological activity of the considered peptides and the side-chain conformations of amino-acid residues 2 and 8.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 113-120
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł