- Tytuł:
- Synthesis, characterization and biological property of 3-(5-bromothiophen-2-yl)-6-phenyl-1,7a-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives
- Autorzy:
-
Joshi, Harsh H.
Parsania, M. V. - Powiązania:
- https://bibliotekanauki.pl/articles/1075472.pdf
- Data publikacji:
- 2019
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
antibacterial
thiadiazole
triazole - Opis:
- A library of novel 3-(5-bromothiophen-2-yl)-6-phenyl-1,7a-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole were synthesized in excellent yields via domino one-pot two component reactions of 4-amino-3-(5-bromothiophen-2-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thiol and benzoic acid derivatives respectively. A triazolo-thiadiazole system may be viewed as a cyclic analogue of two very important components - thiosemicarbazide and biguanide which often display diverse biological activities. The significant advantages of this reaction include one-pot process, simple work-up procedure, excellent yields and no column chromatographic purification. All intermediates and final compounds were confirmed by 1H NMR, 13C NMR, Mass Spectroscopy methods and IR analysis.
- Źródło:
-
World Scientific News; 2019, 126; 291-298
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł