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Wyszukujesz frazę "Jalilian, A." wg kryterium: Autor


Tytuł:
Production and quality control of 65Zn radionuclide
Autorzy:
Rowshanfarzad, P.
Jalilian, A.
Sabet, M.
Powiązania:
https://bibliotekanauki.pl/articles/148866.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
zinc-65
production
cyclotron
radiochemical separation
quality control
Opis:
Zinc-65 was produced in the Nuclear Research Center for Agriculture and Medicine (NRCAM) by the bombardment of natural copper targets with 30 MeV protons via the 65Cu(p,n)65Zn nuclear reaction. Natural copper was used instead of enriched 65Cu because of the quick decay of undesired radioisotopes. It was also more desirable for cost effectiveness. Cross-section calculations were performed by ALICE nuclear code and the results were compared with the experimental data given in the literature, which showed good agreement. A 160 mi m copper layer target was bombarded with a 150 miA current of 30 MeV protons for 20 min, which resulted in 170 MBq activity of 65Zn product. The yield was 3.4 MBq/miAh. The concentration of the product was 6.8 MBq/ml. Radiochemical separation was carried out by anion exchange chromatography with the yield of about 98%. Quality control of the final product showed a radionuclide purity of more than 98% and no traces of possible impurities (copper) were detected by a colorimetric method with a 1 ppm detection limit using dithizone as the reagent. The materials used for targetry and chemical separation were quite cost-effective.
Źródło:
Nukleonika; 2005, 50, 3; 97-103
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production of [103Pd]Bleomycin complex for targeted therapy
Autorzy:
Jalilian, A.
Yari-Kamrani, Y.
Sadeghi, M.
Powiązania:
https://bibliotekanauki.pl/articles/147472.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
palladium-103
palladium(II) complexes
radiolabeling
bleomycin complexes
radiopharmaceuticals
cyclotron
targeted therapy
Opis:
Due to the anticancer properties of bleomycin (BLM) complexes, production of [103Pd]bleomycin ([103Pd]BLM) was targeted. Palladium-103 (T1/2 = 16.96 d) was produced via the 103Rh(p,n)103Pd nuclear reaction using a natural rhodium target. Proton energy was 18 MeV with 200 mA irradiation for 15 h (final activity 25.9 GBq of 103Pd2+, RCP > 95%, radionuclidic purity > 99%). 103Pd was separated from the irradiated target by anion exchange using a Dowex 1´8 (Cl-)/100-200 mesh resin in the form of Pd(NH3)2Cl2 in order to react with bleomycin to yield [103Pd]BLM. Chemical purity of the final product was in accordance to the accepted limits. [103Pd]BLM was prepared with a radiochemical yield of more than 98% at 80°C in 30 min. The labeling reaction was optimized for time, temperature and ligand concentration. Radiochemical purity of more than 99% was obtained using RTLC with specific activity of about 370 MBq/mmol. The stability of the tracer was checked in the final product and presence of human serum at up to 3 h. The complex was stable in human serum at 37°C up to 2 h of incubation. Biodistribution studies using a SPECT system performed in normal rats in the first 2-3 h.
Źródło:
Nukleonika; 2006, 51, 2; 119-123
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and evaluation of a [66Ga]gallium chitosan complex in fibrosarcoma bearing animal models
Autorzy:
Pourjavadi, A.
Akhlaghi, M.
Jalilian, A. R.
Powiązania:
https://bibliotekanauki.pl/articles/147067.pdf
Data publikacji:
2011
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
chitosan
gallium-66
internal radiotherapy
fibrosarcoma
intratumoral injection
Opis:
[66Ga]gallium chitosan complex was prepared with a high radiochemical purity (greater than 99%) in dilute acetic acid solution. The radiochemical purity of [66Ga]gallium chitosan complex was checked by using paper chromatography technique. The prepared complex solution was injected intratumoral to fibrosarcoma-bearing mice and the leakage of radioactivity from injection site was investigated. Approximately, 85.4% of the injected dose was retained in the injection site 54 h after injection and most of the leaked radioactivity was accumulated in the blood, liver (0.5%) and lung (6.5%).
Źródło:
Nukleonika; 2011, 56, 1; 35-40
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of [61Cu]DTPA complex as a possible PET tracer
Autorzy:
Jalilian, A.
Rowshanfarzad, P.
Sabet, M.
Kamalidehghan, M.
Powiązania:
https://bibliotekanauki.pl/articles/147476.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
copper-61
DTPA
labeling
PET
radiopharmaceuticals
Opis:
Copper-61 (T1/2 = 3.33 h) produced via the 64Zn(p,alfa)61Cu nuclear reaction, using a natural zinc target, was separated from the irradiated target material by two ion exchange chromatography steps and was used for the preparation of [61Cu]-diethylenetriaminepentacetate ([61Cu]DTPA) using freshly-prepared DTPA cyclic dianhydride. An electroplated natural zinc layer on a gold-coated copper backing was irradiated with 22 MeV protons (22 12 MeV on the target, 180 miA irradiation, 3.2 h, final activity 220 GBq of 61Cu2+, RCY > 95%, radionuclidic purity > 99%, 60Cu as the only radionuclidic impurity; T1/2 = 23.7 min). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [61Cu]DTPA was prepared with a radiochemical yield of more than 80% starting with 61CuOAc ligand at room temperature after 30 min. RTLC showed the radiochemical purity of more than 99%. The specific activity obtained was about 9.1 TBq/mmol. The tracer was shown to be stable in the final product and in the presence of human serum at 37°C up to 3 h.
Źródło:
Nukleonika; 2006, 51, 2; 111-117
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and biodistribution of [201Tl](III)vancomycin complex in normal rats
Autorzy:
Jalilian, A.
Hosseini, M.
Karimian, A.
Saddadi, F.
Sadeghi, M.
Powiązania:
https://bibliotekanauki.pl/articles/146167.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
thallium-201
vancomycin
labeling
SPECT
radiopharmaceuticals
infection
Opis:
Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 š 1% by RTLC. A specific activity of about 4.14 x 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.
Źródło:
Nukleonika; 2006, 51, 4; 203-208
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production and quality control of 66Ga radionuclide
Autorzy:
Sabet, M.
Rowshanfarzad, P.
Jalilian, A.
Ensaf, M.
Rajamand, A.
Powiązania:
https://bibliotekanauki.pl/articles/146278.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
gallium-66
cyclotron
radiochemical separation
target recovery
Opis:
The purpose of this study was to develop the required targetry and radiochemical methods for production of 66Ga, according to its increasing applications in various fields of science. The 66Zn(p,n)66Ga reaction was selected as the best choice for the production of 66Ga. The targets were bombarded with 15 MeV protons from cyclotron (IBA-Cyclone 30) at the Nuclear Research Center for Agriculture and Medicine (NRCAM) with a current of 180 mA for 67 min. ALICE and SRIM (Stopping and Range of Ions in Matter) nuclear codes were used to predict the optimum energy and target thickness. Targets were prepared by electroplating 95.73% enriched 66Zn on a copper backing. Chemical processing was performed by a no-carrier-added method consisting of ion exchange chromatography and liquid-liquid extraction. Anion exchange chromatography was also used for the recovery of target material. Quality control of the product was carried out in two steps of chemical and radionuclide purity control. The activity of 66Ga was 82.12 GBq at EOB and the production yield was 410.6 MBq/mAh. The radiochemical separation yield was 93% and the yield of chemical recovery of the target material was 97%. Quality control tests showed a radionuclide purity higher than 97% and the amounts of chemical impurities were in accordance with the United States Pharmacopoeiae levels.
Źródło:
Nukleonika; 2006, 51, 3; 147-154
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of [66Ga]oxine complex; a possible PET tracer
Autorzy:
Jalilian, A.
Rowshanfarzad, P.
Sabet, M.
Rahiminejad-Kisomi, A.
Rajamand, A.
Powiązania:
https://bibliotekanauki.pl/articles/146276.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
gallium-66
oxine
positron emission tomography
blood cell labeling
stability
Opis:
The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/mAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 š 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.
Źródło:
Nukleonika; 2006, 51, 3; 155-159
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of a radiolabeled glucagon compound for imaging
Autorzy:
Jalilian, A. R.
Jouiaei, M.
Doroudi, A. R.
Bolourinovin, F.
Garousi, J.
Powiązania:
https://bibliotekanauki.pl/articles/148402.pdf
Data publikacji:
2010
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
glucagons
radiolabeling
biodistribution
Ga-67
Opis:
In order to develop a possible Ga-labeled glucagon (GCG) compound for imaging studies, biosynthetic glucagon (GCG) was labeled with [67Ga]-gallium chloride after conjugation with freshly prepared diethylenetriaminepentaacetic acid dianhydride (ccDTPA). After solid phase purification of the radiolabeled hormone, high performance liquid chromatography (HPLC) and instant thin-layer chromatography (ITLC) showed a radiochemical purity around 95 per cent in optimized conditions (specific activity = 296–370 GBq/mM; labeling efficiency 85 per cent). Preliminary in vivo studies (IDźg–1 per cent) in male wild-type rats showed heart:muscle, liver:muscle, lung:muscle and stomach:muscle ratios to be 5.53, 2.9, 7.56, 3.69, 3.2 (in 5 min), respectively while after 2 h liver:blood, lung:blood and spleen:blood ratios were 14.21, 16.86 and 7.8, respectively. The data suggests 5 min post injection, the tracer is accumulated in GCGR rich tissues which is in agreement with biodistribution studies and reported GCG receptors (GCGRs). The results of the present study can possibly offer a candidate for non-invasive imaging of glucagon receptor related diseased and malignancies such as glucagonoma.
Źródło:
Nukleonika; 2010, 55, 2; 219-224
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and biodistribution of [67Ga]-insulin for SPECT purposes
Autorzy:
Jalilian, A. R.
Garousi, J.
Gholami, E.
Akhlaghi, M.
Bolourinovin, F.
Rajabifar, S.
Powiązania:
https://bibliotekanauki.pl/articles/971522.pdf
Data publikacji:
2007
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
radiogallium
insulin
radiolabeling
biodistribution
radiopharmaceutical
cyclotron
Opis:
Human recombinant insulin was successively labeled with [67Ga]-gallium chloride after conjugation with freshly prepared cyclic DTPA-dianhydride (ccDTPA). The best results of the conjugation were obtained by the addition of 0.5 ml of an insulin pharmaceutical solution (5 mg/ml, in phosphate buffer, pH = 8) to a glass tube precoated with DTPA-dianhydride (0.01 mg) at 25°C with continuous mild stirring for 30 min. Radiothin-layer chromatography (RTLC), instant thin-layer chromatography (ITLC) and high-performance liquid chromatography (HPLC) showed overall radiochemical purity higher than 96% in optimized conditions (specific activity = 300 500 MBq/mg, labeling efficiency 77%). Preliminary in vivo studies with normal rats were performed to determine the biodistribution of the radiotracer up to 110 h. They showed a high liver uptake of the tracer which is consistent with other reported radiolabeled insulins.
Źródło:
Nukleonika; 2007, 52, 4; 145-151
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies
Autorzy:
Rowshanfarzad, P.
Jalilian, A.
Kiyomarsi, M.
Sabet, M.
Karimian, A.
Moradkhani, S.
Mirzaii, M.
Powiązania:
https://bibliotekanauki.pl/articles/146165.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
rubidium-82m
quality control
animal study
cyclotron
Opis:
Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.
Źródło:
Nukleonika; 2006, 51, 4; 209-215
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cyclotron production of technetium radionuclides using a natural metallic molybdenum thick target and consequent preparation of [Tc]-BRIDA as a radio-labelled kit sample
Autorzy:
Targholizadeh, H.
Raisali, G.
Jalilian, A. R.
Rostampour, N.
Ensaf, M.
Dehghan, M. K.
Powiązania:
https://bibliotekanauki.pl/articles/148477.pdf
Data publikacji:
2010
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
technetium
molybdenum target
thermal spray method
technetium radiochemical separation
radio--labelling
Opis:
Numerous studies have focused on the use of accelerators for production of 99mTc, but all of these investigations have been performed at low-level currents. In this research, for the first time, we have constructed a high power level natural Mo target for production of 99mTc radioisotope using cyclotrons. A high purity natural molybdenum target (130 mg/cm2), suitable for proton beam power level of several kilowatts, has been constructed using a thermal spray coating method. The target was irradiated in a Cyclone30 accelerator using 160 mi A of 25 MeV proton beam energy for 1000 mi A-h. The activity of produced 99mTc was measured as 2.75 Ci. The technetium radionuclides produced were extracted using an MEK organic phase, followed by preparation of Tc-BRIDA as a radio-labelled kit sample. Animal biodistribution studies have been performed in rats. After administration of the radio-labelled Tc-BRIDA in rats, we observed most of the radioactivity accumulated in intestine as expected for IDA derivatives. The results of measurements show a successful production of Tc radionuclides (including 99mTc) in the bombarded target and subsequent labelling of the kit with Tc. It is anticipated that the developed coating method for the production of high power Mo targets using enriched 100Mo and a proton beam of about 1 mA is capable of producing about 100 Ci of 99mTc per irradiated target. The developed high power Mo target, if constructed using enriched 100Mo, could be a practical method for a large-scale production of 99mTc for local applications near cyclotron facilities.
Źródło:
Nukleonika; 2010, 55, 1; 113-118
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of 153Sm-DTPA-rituximab for radioimmunotherapy
Autorzy:
Bahrami-Samani, A.
Ghannadi-Maragheh, M.
Jalilian, A. R.
Yousefnia, H.
Garousi, J.
Moradkhani, S.
Powiązania:
https://bibliotekanauki.pl/articles/148154.pdf
Data publikacji:
2009
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
radiopharmaceutical
samarium-153
rituximab
targeted therapy
SPECT
Opis:
Combining beta-particle effect with therapeutic properties of anti-CD20 monoclonal antibody in lymphomas, Mabthera™ (rituximab) was targeted in this study. The antibody was labeled with 153Sm-samarium chloride (185 MBq) after conjugation with freshly prepared ccDTPA. Conjugated-rituximab was obtained by the addition of 1 ml of a rituximab pharmaceutical solution (5 mg/ml, in phosphate buffer, pH = 7.8) to a glass tube precoated with freshly prepared ccDTPA (0.01–0.1 mg) at 25 degrees centigrade. Sm-153 chloride was obtained by a thermal neutron flux (5 × 1013 nźcm–2źs–1) of an enriched 152Sm2O3 sample, dissolved in acidic media. Radiolabeling was performed in one hour by the addition of DTPA-rituximab conjugate at room temperature. Radiochemical purity of 96% (ITLC) and 98% (HPLC) were obtained for the final radioimmunoconjugate (specific activity = 120 TBq/mmol). The final isotonic 153Sm-rituximab complex was checked by gel electrophoresis for protein integrity retention. Biodistribution studies in normal rats were performed to determine radioimmunoconjugate distribution up to 24 h. SPECT images were also obtained using 103 keV photons up to 48 h.
Źródło:
Nukleonika; 2009, 54, 4; 271-277
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging
Autorzy:
Jalilian, A. R.
Zolghadri, S.
Faghihi, R.
Yousefnia, H.
Garousi, J.
Shafaii, K.
Bolourinovin, F.
Powiązania:
https://bibliotekanauki.pl/articles/148094.pdf
Data publikacji:
2009
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
copper-61
8-hydroxyquinoline
positron emission tomography
fibrosarcoma
Opis:
Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. 61Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 miA) via the natZn(p, xn)61Cu nuclear reaction with a yield of 3.33 mCi/miAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively.
Źródło:
Nukleonika; 2009, 54, 3; 175-179
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biological evaluation of [18F]-nifedipine as a novel PET tracer for L-type calcium channel imaging
Autorzy:
Sadeghpour, H.
Jalilian, A. R.
Akhlaghi, M.
Shafiee, A.
Mirzaii, M.
Miri, R.
Saddadi, F.
Powiązania:
https://bibliotekanauki.pl/articles/147732.pdf
Data publikacji:
2008
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
dihydropyridines
flourine-18
PET
biodistribution
Opis:
Due to interesting role of dihydropyridines in cardiovascular diseases and drug resistance studies and lack of a fluorine-18 labeled imaging agent for L-type calcium channel studies, this study was designed. [18F]Dimethyl 2-(fluoromethyl)-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2 was prepared in no-carrier-added (n.c.a.) form from a starting brominated compound in one step at 80°C in Kryptofix2.2.2/[18F]. Compound 2 was administered to normal rats via their tail veins for preliminary biodistribution studies and the ID/g% of the labeled compound was determined up to 3 h post injections. Coincidence images were obtained in rats 5 to 120 min. Radiofluorination on bromo precursor gave a fluorinated compound in 95% radiochemical purity and a 8% yield shown by RTLC and HPLC. Biodistribution studies showed that the tracer is accumulated in the heart in the first few minutes, followed by metabolism resulting in very soluble 18F-containing metabolites eliminated through the urinary tract. In coincidence images, the target organ was shown to be the heart. Lung had high accumulation possibly due to the presence of Ca2+ channels and/or hydrolyzing enzymes showing a significant myocardial uptake at 120 min. The data demonstrates a significant agreement with the reported L-type calcium channels throughout the animal body. To our knowledge, this is the first example of 18F-DHPs in the literature.
Źródło:
Nukleonika; 2008, 53, 4; 151-154
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of 62Zn bleomycin as a possible PET tracer
Autorzy:
Jalilian, A.
Fateh, B.
Ghergherehchi, M.
Karimian, A.
Moradkhani, S.
Kamali-Dehghan, M.
Tabeie, F.
Powiązania:
https://bibliotekanauki.pl/articles/148678.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
PET
pharmacokinetics
biodistribution
62Zn
bleomycin
Opis:
Abstract Bleomycin (BLM), labeled with radioisotopes, is widely used in therapy and diagnosis. In this study, BLM was labeled with 62Zn for oncologic PET studies. The complex was obtained at pH = 2 in saline at 90°C in 25 min. Radio-TLC showed an overall radiochemical yield of 95 97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Preliminary in vivo studies were performed to determine complex stability and distribution of 62Zn BLM in normal and fibrosarcoma-bearing mice. 62Zn BLM accumulated significantly in induced fibrosarcoma tumors in mice according to biodistribution/imaging studies. 62Zn BLM can be used in PET oncology studies due to its suitable physicochemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in larger mammals.
Źródło:
Nukleonika; 2005, 50, 4; 143-148
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł

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