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Wyświetlanie 1-2 z 2
Tytuł:
Sociodemographic factors affecting the disease acceptance in the group of women with postmenopausal osteoporosis
Autorzy:
Górczewska, Bogumiła
Jakubowska-Pietkiewicz, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/2084909.pdf
Data publikacji:
2022-06-08
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
AIS
women
sociodemographic factors
osteoporosis
acceptance of disease
place of residence
Opis:
ObjectivesAssessment of the disease acceptance level in women with osteoporosis depending on selected sociodemographic factors.Material and MethodsThe study included a group of 198 women, aged M±SD 72.3±8.59 years, diagnosed with postmenopausal osteoporosis and treated in 2 Osteoporosis Treatment Centres in Łódź. A questionnaire survey and Acceptance of Illness Scale (AIS) were applied in the study. Based on the questionnaire, the authors collected sociodemographic data (including age, marital status, place of residence, financial status) which the authors subsequently analyzed using a statistical program.ResultsThe respondents living in the countryside, with primary education and a very difficult financial situation manifested a low disease acceptance level. The authors have shown that postmenopausal osteoporosis acceptance level significantly depends on the age (p = 0.0024), place of residence (p = 0.0044), education (p < 0.001) and affluence (p = 0.0049), however, it is not related to duration of the disease.ConclusionsPostmenopausal osteoporosis acceptance level depended on age, place of residence, education and affluence level, however, it was not related to the disease duration. Psychological aspects, including assessment according to the disease acceptance scale, constitute a factor influencing mental health, therefore they should be included in evaluation of therapy effectiveness in patients chronically treated for osteoporosis.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 3; 273-283
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mutations in the COL1A1 and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III
Autorzy:
Augusciak-Duma, Aleksandra
Witecka, Joanna
Sieron, Aleksander
Janeczko, Magdalena
Pietrzyk, Jacek
Ochman, Karolina
Galicka, Anna
Borszewska-Kornacka, Maria
Pilch, Jacek
Jakubowska-Pietkiewicz, Elzbieta
Powiązania:
https://bibliotekanauki.pl/articles/1038526.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
osteogenesis imperfecta
COL1A1
COL1A2
mutation
polymorphism
Opis:
Although over 85% of osteogenesis imperfecta (OI) cases are associated with mutations in the procollagen type I genes (COL1A1 or COL1A2), no hot spots for the mutations were associated with particular clinical phenotypes. Eight patients that were studied here, diagnosed with OI by clinical standards, are from the Polish population with no ethnic background indicated. Previously unpublished mutations were found in six out of those eight patients. Genotypes for polymorphisms (Sp1 - rs1800012 and PvuII - rs412777), linked to bone formation and metabolism were determined. Mutations were found in exons 2, 22, 50 and in introns 13 and 51 of the COL1A1 gene. In COL1A2, one mutation was identified in exon 22. Deletion type mutations in COL1A1 that resulted in OI type I had no effect on collagen type I secretion, nor on its intracellular accumulation. Also, a single base substitution in I13 (c.904-9 G>T) was associated with the OI type I. The OI type III was associated with a single base change in I51 of COL1A1, possibly causing an exon skipping. Also, a missense mutation in COL1A2 changing Gly→Cys in the central part of the triple helical domain of the collagen type I molecule caused OI type III. It affected secretion of the heterotrimeric form of procollagen type I. However, no intracellular accumulation of procollagen chains could be detected. Mutation in COL1A2 affected its incorporation into procollagen type I. The results obtained shall help in genetic counseling of OI patients and provide a rational support for making informed, life important decisions by them and their families.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 79-86
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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