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    Tytuł:
    Review of technical methods of landfill sealing and reclamation in the world
    Przegląd technicznych metod uszczelniania i rekultywacji składowisk odpadów na świecie
    Autorzy:
    Jakimiuk, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2083837.pdf
    Data publikacji:
    2022
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    waste
    landfill reclamation
    synthetic barrier
    leachates
    Opis:
    Landfills, even properly designed, constructed, and operated, are facilities that in the future can be a potential source of pollution of surface and groundwater and atmospheric air. Especially, old municipal landfills were very often established in inappropriate soil and water conditions, which contributed much more to the release of toxic leachate into the ground. This happened due to lack of sufficient regulation and control systems in this area. Reclamation of degraded sites became a kind of rescue for contaminated areas. However, this process was not always carried out in a proper way. This study presents the trends of landfills sealing and their reclamation over the years in different countries.
    Źródło:
    Acta Scientiarum Polonorum. Architectura; 2022, 21, 1; 41-50
    1644-0633
    Pojawia się w:
    Acta Scientiarum Polonorum. Architectura
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Review of technical methods of landfill sealing and reclamation in the world
    Przegląd technicznych metod uszczelniania i rekultywacji składowisk odpadów na świecie
    Autorzy:
    Jakimiuk, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2106763.pdf
    Data publikacji:
    2022
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    waste
    landfill reclamation
    synthetic barrier
    leachates
    odpady
    rekultywacja składowisk
    syntetyki
    odcieki
    Opis:
    Landfills, even properly designed, constructed, and operated, are facilities that in the future can be a potential source of pollution of surface and groundwater and atmospheric air. Especially, old municipal landfills were very often established in inappropriate soil and water conditions, which contributed much more to the release of toxic leachate into the ground. This happened due to lack of sufficient regulation and control systems in this area. Reclamation of degraded sites became a kind of rescue for contaminated areas. However, this process was not always carried out in a proper way. This study presents the trends of landfills sealing and their reclamation over the years in different countries.
    Składowiska odpadów, nawet prawidłowo zaprojektowane, wykonane i eksploatowane, są obiektami, które w przyszłości są potencjalnym źródłem zanieczyszczeń wód powierzchniowych i podziemnych oraz powietrza atmosferycznego. Stare składowiska odpadów komunalnych z powodu braku odpowiednich regulacji prawnych często powstawały w nieodpowiednich warunkach gruntowo-wodnych, co w znacznym stopniu przyczyniało się do uwalniania toksycznych odcieków do gruntu. Rekultywacja terenów zdegradowanych jest rodzajem ratunku dla obszarów zanieczyszczonych. W niniejszym opracowaniu przedstawiono przegląd metod uszczelniania i rekultywacji składowisk odpadów na przestrzeni lat w różnych krajach na świecie.
    Źródło:
    Acta Scientiarum Polonorum. Architectura; 2022, 21, 2; 41-50
    1644-0633
    Pojawia się w:
    Acta Scientiarum Polonorum. Architectura
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stability of αB-crystallin gene expression in canine mammary gland neoplasms. Should it be considered as circulating tumor cell genetic marker?
    Autorzy:
    Chmielewska-Krzesińska, M.
    Jakimiuk, A.
    Wąsowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087495.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    αB-crystallin (CRYAB)
    canine mammary gland tumor
    circulating tumor cells (CTC)
    cytokeratin 17 (CK17)
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 3; 523-529
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of landfill protection systems in Japan – a case study
    Ocena systemów ochronnych składowisk odpadów w Japonii – studium przypadku
    Autorzy:
    Jakimiuk, A.
    Matsui, Y.
    Podlasek, A.
    Vaverková, M.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/28765740.pdf
    Data publikacji:
    2022
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    Japan
    waste management
    sanitary landfill
    sealing
    solid waste landfill
    municipal waste landfill
    untreated waste
    case study
    Źródło:
    Acta Scientiarum Polonorum. Architectura; 2022, 21, 4; 21-31
    1644-0633
    Pojawia się w:
    Acta Scientiarum Polonorum. Architectura
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The case of a massive Syphacia obvelata invasion in laboratory rats: diagnosis, treatment and prevention
    Autorzy:
    Michalski, M.
    Chmielewska-Krzesinska, M.
    Jakimiuk, A.
    Losiewicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/6651.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Syphacia obvelata
    invasion
    laboratory animal
    rat
    diagnosis
    treatment
    prevention
    Źródło:
    Annals of Parasitology; 2016, 62, Suppl.
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Environmental risk factors and epigenetic alternations in psoriasis
    Autorzy:
    Roszkiewicz, M.
    Dopytalska, K.
    Szymańska, E.
    Jakimiuk, A.
    Walecka, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085926.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    psoriasis
    habits
    environmental factors
    epigenetic alternations
    Opis:
    Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world’s population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone’s modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 335-342
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of super-selective uterine artery branch embolization and methotrexate in cervical pregnancy - case reports and literature review
    Autorzy:
    Oleksik, T.P.
    Pluta, K.
    Issat, T.
    Jakimiuk, A.
    Wierzba, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/28762721.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2021, 28, 3; 521-524
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zebrafish: an animal model for research in veterinary medicine
    Autorzy:
    Nowik, N.
    Podlasz, P.
    Jakimiuk, A.
    Kasica, N.
    Sienkiewicz, W.
    Kaleczyc, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/31997.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The zebrafish (Danio rerio) has become known as an excellent model organism for studies of vertebrate biology, vertebrate genetics, embryonal development, diseases and drug screening. Nevertheless, there is still lack of detailed reports about usage of the zebrafish as a model in veterinary medicine. Comparing to other vertebrates, they can lay hundreds of eggs at weekly intervals, externally fertilized zebrafish embryos are accessible to observation and manipulation at all stages of their development, which makes possible to simplify the research techniques such as fate mapping, fluorescent tracer time-lapse lineage analysis and single cell transplantation. Although zebrafish are only 2.5 cm long, they are easy to maintain. Intraperitoneal and intracerebroventricular injections, blood sampling and measurement of food intake are possible to be carry out in adult zebrafish. Danio rerio is a useful animal model for neurobiology, developmental biology, drug research, virology, microbiology and genetics. A lot of diseases, for which the zebrafish is a perfect model organism, affect aquatic animals. For a part of them, like those caused by Mycobacterium marinum or Pseudoloma neutrophila, Danio rerio is a natural host, but the zebrafish is also susceptible to the most of fish diseases including Itch, Spring viraemia of carp and Infectious spleen and kidney necrosis. The zebrafish is commonly used in research of bacterial virulence. The zebrafish embryo allows for rapid, non-invasive and real time analysis of bacterial infections in a vertebrate host. Plenty of common pathogens can be examined using zebrafish model: Streptococcus iniae, Vibrio anguillarum or Listeria monocytogenes. The steps are taken to use the zebrafish also in fungal research, especially that dealing with Candida albicans and Cryptococcus neoformans. Although, the zebrafish is used commonly as an animal model to study diseases caused by external agents, it is also useful in studies of metabolic disorders including fatty liver disease and diabetes. The zebrafish is also a valuable tool as a model in behavioral studies connected with feeding, predator evasion, habituation and memory or lateralized control of behavior. The aim of the present article is to familiarize the reader with the possibilities of Danio rerio as an experimental model for veterinary medicine.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Budowle wodne i melioracyjne Lubelszczyzny
    Water and hydro-engineering structures in the Lublin region
    Autorzy:
    Pichla, A.
    Jakimiuk, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/62055.pdf
    Data publikacji:
    2014
    Wydawca:
    Polska Akademia Nauk. Stowarzyszenie Infrastruktura i Ekologia Terenów Wiejskich PAN
    Tematy:
    Polska
    woj.lubelskie
    zasoby wodne
    retencja wodna
    melioracje
    budowle wodnomelioracyjne
    regulacja rzek
    regulacja ciekow
    zabezpieczenia przeciwpowodziowe
    zbiorniki wodne
    Opis:
    Polska jest krajem o małych zasobach wodnych i jeden z niewielu krajów europejskich, który zagrożony jest deficytem wody. Zasoby wodne wód powierzchniowych w woj. lubelskim są znacznie niższe niż średnie w kraju i należą do najmniejszych w Polsce. Zobowiązuje to do racjonalnego i oszczędnego gospodarowania zasobami wodnymi, ze szczególną ich ochroną pod względem jakościowym i ilościowym. Najbardziej skutecznym i efektywnym sposobem kształtowania zasobów wodnych jest retencjonowanie wód powierzchniowych dla łagodzenia deficytu wody, w szczególności w okresach suszy. Podstawowym zadaniem rolnictwa w kraju i w woj. lubelskim (dobre gleby) jest zaspokojenie ludności na stale wzrastające zapotrzebowanie na żywność. Głównym czynnikiem służącym do osiągnięcia coraz to wyższych efektów produkcyjnych są melioracje wraz z budowlami wodno – melioracyjnymi. Pozwalają one na racjonalne wykorzystanie obiegu wody w środowisku kształtowanym przez człowieka dla potrzeb rolnictwa. Podano stan, wybrane przykłady i potrzeby stosowania budowli wodno – melioracyjnych w systemach melioracyjnych dla racjonalnej gospodarki wodnej w rolnictwie.
    Poland is considered to have scarce water resources and to be one of the few countries in Europe which are in danger of a water deficit. Surface water resources in the Lubelskie Province are significantly lower than the country’s average and are among the lowest in Poland. This calls for sustainable and sparing water-resources management, combined witch particularly intensive protection of their quality and quantity. The most successful and effective way of forming water resources is surface-water retention aimed at mitigating the water deficit, especially in periods of drought. Catering for the continuously-growing food demand is a primary objective for agriculture in Poland and in the Lubelskie Province (good types of soil). The drainage infrastructure and hydro-engineering buildings are the key factors in increasing the efficiency of production. It allows the sustainable use of water circulation in an environment shaped by man for agricultural purposes. The article includes the condition, selected examples of, and the requirements for, the hydro-engineering buildings to be used in drainage systems for sustainable water management in agriculture.
    Źródło:
    Infrastruktura i Ekologia Terenów Wiejskich; 2014, II/1
    1732-5587
    Pojawia się w:
    Infrastruktura i Ekologia Terenów Wiejskich
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Obserwacje nad behawiorem oraz wybiórczością pokarmową rysi introdukowanych metodą "born to be free" w Puszczy Piskiej
    Observations on food preference of lynxes introduced with the "born to be free" method into the Piska Primeval Forest
    Autorzy:
    Kobus, A.
    Krzywiński, A.
    Jakimiuk, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/882550.pdf
    Data publikacji:
    2016
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Leśny Zakład Doświadczalny. Centrum Edukacji Przyrodniczo-Leśnej w Rogowie
    Tematy:
    rys
    Lynx lynx
    reintrodukcja
    metoda born to be free
    zachowanie sie zwierzat
    wybiorczosc pokarmowa
    Puszcza Piska
    Źródło:
    Studia i Materiały Centrum Edukacji Przyrodniczo-Leśnej; 2016, 18, 4[49A]
    1509-1414
    Pojawia się w:
    Studia i Materiały Centrum Edukacji Przyrodniczo-Leśnej
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of selected serum biochemical and haematological parameters in gilts exposed per os to 100 ppb of zearalenone
    Autorzy:
    Jakimiuk, E.
    Radwinska, J.
    Pomianowski, A.
    Wozny, M.
    Obremski, K.
    Gajecka, M.
    Brzuzan, P.
    Gajecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/30098.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Zearalenone (ZEN) widely contaminates animal feed of plant origin. The recommended safe concentrations of ZEN in feeds for various animal species are set mainly based on the mycotoxin’s hormonal properties (NOEL). Our growing knowledge about biologically active concentrations of ZEN, molecular mechanisms and cells/tissues targeted by ZEN indicates that the harmful effects exerted by this mycotoxin on animals may be far greater than previously believed. This experiment was performed on pre-pubertal gilts divided into a control group (n=9) and an experimental group (ZEN, n=9). The control group received placebo, whereas the experimental group was administered ZEN at a dose of 0.1 mg/kg feed (equivalent to 5 μg/kg BW/day) for 42 days. On days 14, 28 and 42 blood samples were collected from the animals to determine the concentrations of selected zearalenols, serum biochemical and haematological parameters. Conjugated ZEN was found in the blood serum of the experimental gilts. Changes in the analysed biochemical parameters included a transient increase in albumin and cholesterol levels. A statistically significant increase in the concentrations of neutrophilic and acidophilic granulocytes was observed in the white blood cell system. The results indicate that long-term per os exposure of pre-pubertal gilts to low doses of ZEN (below NOEL) has a modulatory effect on liver function and white blood cells.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of mutagenic activity of methyl- and phenylphenanthrenes based on Salmonella test and micronucleus test
    Autorzy:
    Rudnicka, K.
    Tejs, S.
    Budzikur, K. A.
    Mielżyńska-Švach, D.
    Jakimiuk, E.
    Chachaj, A.
    Góra, M.
    Żelazna, K.
    Łuczyński, M. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/363178.pdf
    Data publikacji:
    2013
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie
    Tematy:
    Ames test
    in vitro
    micronucleus test
    mutagenicity
    phenanthrene
    test Amesa
    mutagenność
    test mikrojądrowy
    fenanatren
    Opis:
    Polycyclic aromatic hydrocarbons (PAHs) are widely spread environmental pollutants mainly originating from anthropogenic sources such as fossil fuel combustion, industries, and others. Although a large body of literature exists on the toxicity and carcinogenicity of PAHs, primarily benzo[a]pyrene, toxicity data for phenanthrene deriveratives are very limited. The main aim of the experiment was to investigate if there exists correlation between molecular structure and mutagenic activity of four phenanthrene derivatives: 1 methylphenanthrene, 4 methylphenanthrene, 1 phenylphenanthrene, and 4 phenylphenanthrene. An Ames assay using two strains of histidine dependent Salmonella Typhimurium (TA98 and TA100) was conducted to assess the mutagenic activity of studied compounds both in the presence (+S9) and in the absence (-S9) of an exogenous source of metabolic activation. The compounds were also tested in an in vitro chromosome aberration assay in which V-79 cells were exposed to the phenanthrene derivatives investigated both in the presence and in the absence of metabolic activation. The phenylphenanthrenes showed no mutagenic effect. These compounds occasionally induced significant decrease in the number of revertants in the Ames test. The greatest mutagenic effects were observed for 1 methylphenanthrene after metabolic activation (+S9). In the micronucleus test the greatest mutagenic effect was observed for 4 methylphenanthrene also in the presence of metabolic activation system. The results obtained are comparable to those reported earlier for the methylphenanthrenes.
    Źródło:
    Environmental Biotechnology; 2013, 9, 2; 65-71
    1734-4964
    Pojawia się w:
    Environmental Biotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dichlorodiphenyldichloroethylene (DDE) residue limit exceeded in pig tissues after feed-borne exposure to maximum allowed concentration
    Autorzy:
    Woźny, M.
    Jakimiuk, E.
    Brzuzan, P.
    Florczyk, M.
    Newiadowska, A.
    Obremski, K.
    Gajęcka, M.
    Młynarczuk, J.
    Gajęcki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/363198.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie
    Tematy:
    body burden
    organochlorine pesticides
    pig
    residue
    świnia
    pestycydy chloroorganiczne
    biostężenie
    pozostałość
    Opis:
    Monitoring of undesirable substances by the European Union indicates a presence of natural and anthropogenic pollutants in animal feed that may be of concern for the producers, as well as the veterinary services. Although the literature concerning toxicity of DDT (an insecticide widely used in the past) is extensive, less attention has been focused on the biological properties of DDE and its interactions with other contaminants. This study reports on the concentration profile of p,p’-DDE and two other ogranochlorines (p,p’-DDT, p,p’-DDD) in different tissues of immature gilts after 14, 28, and 42 days of oral exposure to p,p’-DDE alone (0.5mg·kg-1feed·day-1) and in mixture with naturally occurring mycotoxin zearalenone, ZEN (0.5+0.1mg·kg-1feed·day-1). The treatment resulted in a time-dependent accumulation of p,p’-DDE in fat-rich tissues. Although the pesticide’s concentration found in the adipose tissue exceeded the FAO/WHO maximum residue limit (5mg·kg-1 of fat), human dietary risk is little, as it requires a substantial consumption of such contaminated pork fat. Importantly, the high concentration of p,p’-DDE found in the adrenal glands suggests a threat to the animals’ health. Finally, a difference in the accumulation of p,p’-DDE was observed between the groups treated with this compound alone or in mixture with ZEN. This is most likely related to growth performance of the animals, altered by the endocrine disrupting activity of both compounds. Further research should evaluate the effects of p,p-DDE at the observed concentrations on the pigs’ health status and enable the studies of possible interactions with other environmental pollutants.
    Źródło:
    Environmental Biotechnology; 2015, 11, 1; 1-9
    1734-4964
    Pojawia się w:
    Environmental Biotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MicroRNA expression profiles in liver and colon of sexually immature gilts after exposure to Fusarium mycotoxins
    Autorzy:
    Brzuzan, P.
    Wozny, M.
    Wolinska-Niziol, L.
    Piasecka, A.
    Florczyk, M.
    Jakimiuk, E.
    Gora, M.
    Luczynski, M.K.
    Gajecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087983.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    To improve our knowledge of the role of microRNAs (miRs) in responses of the porcine digestive system to two Fusarium mycotoxins, zearalenone (ZEN) and deoxynivalenol (DON), we examined the expression of 7 miRs (miR-9, miR-15a, miR-21, miR-34a, miR-122, miR-125b, and miR-192), previously found to be deregulated in diseased liver and colon cells. In this study, immature gilts were exposed to NOEL doses of ZEN (40 |ig/kg/d), DON (12 |ig/kg/d), ZEN+DON (40 + 12 |ig/kg/d), and placebo (negative control group) for 7,14, 21, 28, 35, and 42 days. Before the treatment, expression levels of the selected miRs were measured in the liver, the duodenum, the jejunum, and the ascending and the descending colon of the gilts. Hierarchical clustering of the tissues by their miR expression profiles was consistent with what would be expected based on the anatomical locations and the physiological functions of the organs, suggesting that functions of the miRs are related to the specificities of the tissues in which they are expressed. A subset of 2 pairs of miRs (miR-21+miR-192 and miR-15a+miR-34a), which were assigned to two distinct clusters based on their tissue abundance, was then evaluated in the liver and the ascending and the descending colon during the treatment. The most meaningful results were obtained from the ascending colon, where a significant effect of the treatment was observed, suggesting that during the exposure to mycotoxins, the pathways involved in cell proliferation and survival were disordered. Changes in miR expression in the liver and the descending colon of the treated gilts were smaller, and were associated more with treatment duration than the exposure to ZEN, DON, or ZEN+DON. Further research should focus on identification of genes whose expression is regulated by these aberrantly expressed miRs. This should facilitate understanding of the miRNA-regulated biological effects of mycotoxins.
    Źródło:
    Polish Journal of Veterinary Sciences; 2015, 18, 1
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of T-2 toxin on percentages of CD4plus, CD8plus, CD4plusCD8plus and CD21plus lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches
    Autorzy:
    Obremski, K.
    Podlasz, P.
    Zmigrodzka, M.
    Winnicka, A.
    Wozny, M.
    Brzuzan, P.
    Jakimiuk, E.
    Wojtacha, P.
    Gajecka, M.
    Zielonka, L.
    Gajecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/30985.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 μg T-2 toxin kg⁻¹ feed) on percentages of CD4⁺ and CD8⁺ T lymphocytes, CD4⁺/CD8⁺ double-positive T lymphocytes, CD21⁺ B cells, and IL-2, IFN-γ, IL-4 and IL-10 mRNA expression levels in porcine ileal Peyer’s patches. The investigated material comprised ileum sections sampled from piglets (aged 8-10 weeks, body weight of 15-18 kg) on days 14, 28 and 42 of the experiment. After 42 days of exposure to T-2, a significant drop in the quantity of the IL-10 product was observed (R=0.94; S.E. 0.49-0.79; p<0.001). A gradual decrease in the amount of IL-4 and IFN-γ cytokine transcripts was found throughout the experiment, but the reported trend was not significant. On experimental days 14 and 42, a significant increase in the percentage of CD8⁺ T lymphocytes was observed in comparison with the control (p=0.04 and p=0.05, respectively), whereas on day 28, a significant decrease in the percentage of the above subpopulation was noted (p=0.00). The percentage of CD21⁺ B cells in the experimental group decreased steadily in comparison with the control, and the observed drop was significant on days 28 and 42 (p=0.06 and p=0.00, respectively). On days 14 and 28, the percentages of CD4⁺ and CD8⁺ T lymphocytes were lower in the experimental animals than in the control group, and the drop reported on day 28 was statistically significant (p=0.03).
    Źródło:
    Polish Journal of Veterinary Sciences; 2013, 16, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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