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    Wyświetlanie 1-3 z 3
    Tytuł:
    The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
    Autorzy:
    Jakubowska, K.
    Pryczynicz, A.
    Dymicka-Piekarska, V.
    Cepowicz, D.
    Jagodzińska, D.
    Lewczuk, Ł.
    Lebelt, A.
    Ozimkiewicz, M.
    Kiszło, P.
    Guzińska-Ustymowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1917712.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    Growth differentiation factor-15
    macrophage inhibitory cytokine-1
    serum.
    Opis:
    Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2016, 6(1); 40-48
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The expression of apoptosis-related proteins in patients with ulcerative colitis
    Autorzy:
    Niewiarowska, K.
    Lebelt, A.
    Gryko, M.
    Pryczynicz, A.
    Famulski, W.
    Czyżewska, J.
    Kemona, A.
    Piekarska-Dymicka, V.
    Jagodzińska, D.
    Guzińska-Ustymowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1916338.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Ulcerative colitis
    Bcl-xl
    Bax
    Bid
    Bcl-2
    Opis:
    Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 75-82
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Numerical studies on the influence of air staging on the temperature of flue gas and emission of gases in the combustion chamber of OP 230 boiler
    Autorzy:
    Hernik, B.
    Jagodzińska, K.
    Matuszek, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/185572.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    combustion
    CFD
    emission
    boiler
    NOx
    spalanie
    emisja
    bojler
    Opis:
    The primary methods of reducing nitrogen oxides, despite the development of more advanced technologies, will continue to be the basis for NOx reduction. This paper presents the results of multivariate numerical studies on the impact of air staging on the flue gas temperature and composition, as well as on NOx emissions in a OP 230 boiler furnace. A numerical model of the furnace and the platen superheater was validated based on measurements using a 0-dimensional model of the boiler. Numerical simulations were performed using the ANSYS Workbench package. It is shown that changes in the distribution of air to OFA nozzles, the angle of the air outflow from the nozzles and the nozzle location involve a change in the flue gas temperature and in the volume of NOx and CO emissions at the furnace outlet.
    Źródło:
    Chemical and Process Engineering; 2018, 39, 1; 59--74
    0208-6425
    2300-1925
    Pojawia się w:
    Chemical and Process Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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