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    Wyświetlanie 1-14 z 14
    Tytuł:
    Dynamiczne tablice trwania życia a przeciętna długość życia w Polsce w latach 2008-2018
    Dynamic life tables and life expectancy in Poland between 2008–2018
    Autorzy:
    Jóźwik, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1827558.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    dynamic life tables
    life expectancy
    life tables
    mortality
    dynamiczne tablice trwania życia
    przeciętne trwanie życia
    umieralność
    tablice trwania życia
    Opis:
    Przy użyciu dynamicznych tablic trwania życia, w artykule zobrazowano zahamowanie tempa wzrostu oczekiwanego trwania życia noworodków w ostatnich latach w Polsce. W tym celu wykorzystane zostały dane z lat 2008–2018 oraz metoda dynamicznego przedłużenia tablic trwania życia zaproponowana przez Franka Dentona oraz Byrona G. Spencera, która zmienia standardowe dla tablic trwania życia założenie o braku zmian prawdopodobieństwa zgonu na założenie stałości dynamik prawdopodobieństwa zgonu. Ta metoda dotychczas nie została opisana w literaturze polskojęzycznej ani użyta w odniesieniu do przekrojowych tablic trwania życia dla Polski. W wyniku zahamowania tempa wzrostu oczekiwanego trwania życia noworodków w latach 2016–2018 widoczne jest skrócenie dynamicznego oczekiwanego trwania życia dla noworodków w 2018 r. o 3,5 roku dla kobiet i 6,6 roku dla mężczyzn w relacji do dynamicznego oczekiwanego trwania życia w 2013 r. Straty w oczekiwanym trwaniu życia są najbardziej widoczne dla młodych i średnio-zaawansowanych grup wiekowych. Ponadto, skrócenie dynamicznego oczekiwanego trwania życia w grupach wiekowych poniżej 80. roku życia jest wyższe dla mężczyzn.
    Using dynamic life tables this article illustrates the inhibition of the growth rate of life expectancy in Poland in recent years. In order to do this, the article exploits data from 2008–2018 and the dynamic extension method proposed by Frank Denton and Byron G. Spencer, which changes the assumption of constant death probability to the assumption of constant dynamic change in death probability. This method has not yet been used in the Polish literature or used with Polish life tables. The article finds that due to the inhibition of growth of life expectancy in 2016–2018, the dynamic life expectancy in 2018 shortened by 3.5 years for women and 6.6 years for men in comparison to dynamic life expectancy in 2013. Moreover, the losses in dynamic life expectancy are mostly visible for young and middle-aged groups. Further, the shortening of dynamic life expectancy for age groups below 80 is greater for men.
    Źródło:
    Studia Demograficzne; 2020, 178, 2; 147-161
    0039-3134
    Pojawia się w:
    Studia Demograficzne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analiza wyników samodzielnej radioterapii chorych na raka endometrium
    Radiotherapy as sole treatment of endometrial cancer. Analysis of treatment outcome
    Autorzy:
    Jóźwik, Piotr
    Karolewski, Kazimierz
    Kojs, Zbigniew
    Jakubowicz, Jerzy
    Blecharz, Paweł
    Urbański, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/908391.pdf
    Data publikacji:
    2007
    Wydawca:
    Medical Communications
    Tematy:
    brachytherapy
    endometrial cancer
    irradiation
    radiotherapy
    Opis:
    Radiotherapy was used as a stand-alone therapeutic modality in 155 patients with endometrial cancer, treated at the Cracow Branch of the Center of Oncology since 1988 thru 1999. In these patients surgical excision was impossible due to far-advanced cancer (clinical stages III and IV) (n=50), severe comorbidity and poor performance status (n=105). In this patient population, 50 persons in clinical stage I received intracavitary brachytherapy, while the remaining 105 patients in clinical stages II, III and IVA received external beam irradiation followed by intracavitary brachytherapy. In the entire group (n=155), cumulative symptom-free 5 year survival rate was 51% (n=79). In relation to tumour grade, 5 year symptom- free survival rate was 70.3% in patients with well differentiated tumour, 43.5% in those with intermediate- grade tumour and only 20% in persons with poorly differentiated cancer. In patients with stage I endometrial cancer, symptom-free 5 year survival rate was 82% (n=41/50); in clinical stage II – 54.5% (30/55), in clinical stages III and IVA – 16% (8/50). Multivariate Cox analysis revealed that independent prognostic factors were clinical stage and tumour grade. Cure rates were 82%, 54.4% and 16% in clinical stages I, II and III/IVA, respectively. Symptom-free 5-year survival rates were 70.3%, 43.5% and 20% in well-differentiated, intermediate- and poorly-differentiated tumours, respectively. Severe late complications of radiotherapy (3rd and 4th degree) developed in 3.5% of patients.
    W latach 1988-1999 w krakowskim Oddziale Centrum Onkologii (COOK) leczono pierwotnie napromienianiem 155 chorych na raka endometrium (RE), u których niemożliwe było wykonanie zabiegu operacyjnego z powodu zbyt dużego zaawansowania raka (stopnie III i IV) (50 chorych), ciężkich chorób towarzyszących i złego stanu sprawności (105 chorych). U 50 chorych na RE w I stopniu zaawansowania zastosowano wyłącznie brachyterapię dojamową, u pozostałych 105 (stopnie II, III i IVA) brachyterapię dojamową skojarzono z uprzednią teleradioterapią. Spośród 155 chorych badanej grupy 79 pacjentek (51%) przeżyło 5 lat bez objawów nowotworu. Pięć lat bez objawów nowotworu przeżyło 70,3% chorych na wysoko zróżnicowanego, 43,5% na średnio zróżnicowanego i 20% na nisko zróżnicowanego raka. Spośród 50 chorych na raka w I stopniu zaawansowania 5 lat bez objawów choroby przeżyło 41 (82%) pacjentów, spośród 55 chorych na raka w II stopniu zaawansowania - 30 (54,5%), a spośród 50 chorych na raka w stopniach III i IVA - tylko 8 (16%). W wielocechowej analizie Coksa niezależnymi czynnikami prognostycznymi były zaawansowanie kliniczne i stopień zróżnicowania raka. Wyleczono 82% chorych na RE w I stopniu zaawansowania, 54,5% w II stopniu i tylko 16% w stopniach III i IVA. Pięć lat bez objawów nowotworu przeżyło odpowiednio 70,3%, 43,5% i 20% chorych na wysoko, średnio i nisko zróżnicowanego raka. Odległe, ciężkie powikłania (stopnie 3. i 4.) radioterapii wystąpiły jedynie u 3,5% chorych.
    Źródło:
    Ginekologia Onkologiczna; 2007, 5, 3; 151-158
    1731-5379
    Pojawia się w:
    Ginekologia Onkologiczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of changes in fuel delivery rate by electromagnetic injectors in a common rail system during simulated operation
    Autorzy:
    Kamiński, Mariusz
    Budzyński, Piotr
    Hunicz, Jacek
    Józwik, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1841746.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
    Tematy:
    common rail
    fuel delivery rate
    injector operation
    Opis:
    The objective of this study was to determine changes in fuel delivery rate by common rail system injectors during their simulated operation on a test stand. Four Bosch injectors used, among others, in Fiat 1.3 Multijet engines were tested. The injectors were operated on a test rig at room temperature for 500 hours (more than 72 million work cycles). During the test, pressure and injection frequency were changed. Changes in the operating parameters were estimated based on obtained injection characteristics and effective flow area determined thereby. The observed changes in fuel delivery rate were compared with results of the surface analysis of control valves and nozzle needles. Despite the stated lack of wear, significant changes in the dynamics of injector operation were observed, particularly at short injection times. Small pilot injections cannot be corrected by the fuel injection control system because they do not affect the changes in torque; however, they do affect the combustion process. This creates conditions for increased emission of toxic exhaust components.
    Źródło:
    Eksploatacja i Niezawodność; 2021, 23, 2; 352-358
    1507-2711
    Pojawia się w:
    Eksploatacja i Niezawodność
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Skuteczność instrumentów europejskiej polityki spójności wspierających działalność przedsiębiorstw (na przykładzie województwa lubelskiego)
    Efficiency of the instruments of the European cohesion policy supporting the work of companies (on the example of the Lublin Province)
    Autorzy:
    Jóźwik, Bartosz
    Gorbaniuk, Oleg
    Sagan, Mariusz
    Zalewa, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/30145437.pdf
    Data publikacji:
    2011
    Wydawca:
    Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
    Tematy:
    Unia Europejska
    polityka spójności
    skuteczność
    European Union
    cohesion policy
    efficiency
    Opis:
    In the article an appraisal of the efficiency of the instruments of the European Cohesion Policy is presented that is effected in the regional dimension in the Lublin Province. The appraisal was based on the studies of 443 entrepreneurs’ opinions. The appraisal of the efficiency of the cohesion policy effected on the regional level concerns four areas: supporting the cooperation between companies and institutions belonging to the environment of business; supporting local and regional partnerships in order to work out and implement the strategies of predicting and managing economic change; supporting the work of companies by specialist consultancy; and facilitating access to external financing sources for companies. In the conclusion recommendations are contained for institutions managing (mediating) European Union’s funds in the above mentioned areas in the Lublin Province.
    Źródło:
    Roczniki Ekonomii i Zarządzania; 2011, 3; 167-184
    2081-1837
    2544-5197
    Pojawia się w:
    Roczniki Ekonomii i Zarządzania
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transfer technologii i wiedzy do przedsiębiorstw województwa lubelskiego
    Transfer of Technology and Knowledge to Enterprises in Poland’s Lublin Province
    Autorzy:
    Sagan, Mariusz
    Zalewa, Piotr
    Gorbaniuk, Oleg
    Jóźwik, Bartosz
    Powiązania:
    https://bibliotekanauki.pl/articles/574314.pdf
    Data publikacji:
    2011-04-30
    Wydawca:
    Szkoła Główna Handlowa w Warszawie. Kolegium Analiz Ekonomicznych
    Tematy:
    technology transfer
    knowledge transfer
    entrepreneurship
    regional development
    innovation
    statistical inference
    Opis:
    The authors analyze the ongoing transfer of technology and knowledge to enterprises in Poland’s eastern Lublin province. They are particularly interested in the conditions and scope of the process. For the needs of the study, they have conducted a survey on a sample of 443 firms. In the survey, data were obtained from companies via the internet. To analyze the data, different statistical methods were used, including statistical inference procedures. The analysis showed that the surveyed companies most often used free and generally accessible sources of technology transfer, such as publications, the internet, and free conferences. Only businesses from industry derived substantial benefits from a transfer of knowledge and innovation from universities while working to implement ideas resulting from their own research and development. Most of the surveyed companies declared their willingness to work with university-level schools. The study confirmed that cooperation with universities and R&D centers encourages firms to look for the most advanced knowledge and technology. Other factors include participation in business clusters, and cooperation with innovation and technology transfer centers in implementing marketing and organizational innovations. The research done by Sagan, Zalewa, Gorbaniuk and Jóźwik complements the existing body of knowledge on the transfer of knowledge and technology to less well-developed regions, the authors say. It could thus help various Polish regions create new development strategies and use European Union funds under the bloc’s financial perspective for 2014-2020.
    Źródło:
    Gospodarka Narodowa. The Polish Journal of Economics; 2011, 247, 4; 85-98
    2300-5238
    Pojawia się w:
    Gospodarka Narodowa. The Polish Journal of Economics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A two-stage model of an arteriovenous fistula maturation process
    Autorzy:
    Jodko, Daniel M.
    Obidowski, Damian S.
    Reorowicz, Piotr
    Jóźwik, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/27324149.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    hemodialysis
    anastomosis
    fluid structure interaction
    wall shear stress
    arteriovenous fistula AVF
    AVF maturation
    hemodializa
    zespolenie
    interakcja struktury płynu
    naprężenie ścinające ściany
    przetoka tętniczo-żylna AVF
    dojrzewanie AVF
    Opis:
    Purpose: An arteriovenous fistula has been a widely accepted vascular access for hemodialysis, however, a fistula maturation process is still not fully understood. In the short period of time, right after vein and artery shunting, the physical and biological changes take place mainly in the venous wall. A two-stage modeling method of arteriovenous fistula maturation process was proposed and presented. Methods: The first stage of the maturation was modeled with two-way coupled fluid structure interaction computer simulations. Whereas for the second, biological stage, a model was based on the change in the elasticity of the venous wall due to wall shear stress (WSS) modifications. Results: The relation between stress and radial and circumferential strain, based on Lame’s theory, makes possible to introduce a mathematical model defining modulus of elasticity, averaged WSS, and venous diameter as time functions. The presented model enables one to predict changes in the monitored parameters in the arteriovenous fistula taking place in the time longer than 90 days. Conclusions: We found that probably the majority of fistulas can be assessed to be mature too early, when the adequate blood flow rate is achieved but mean WSS still remains at the non-physiological level (>10 Pa).
    Źródło:
    Acta of Bioengineering and Biomechanics; 2020, 22, 2; 139--153
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of overset mesh approach in the investigation of the Savonius wind turbines with rigid and deformable blades
    Autorzy:
    Marchewka, Emil
    Sobczak, Krzysztof
    Reorowicz, Piotr
    Obidowski, Damian Stanisław
    Jóźwik, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1955051.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    CFD
    savonius
    deformable blade
    overset mesh
    sliding mesh
    Opis:
    Machines utilising renewable energy constantly undergo research aimed at raising their efficiency. One of them is a Savonius wind turbine, where scientists propose adjustments to improve its aerodynamic properties. At present, their assessment is usually performed by means of transient computational fluid dynamics simulations with two- or threedimensional models. In this paper, the overset (chimera) mesh approach was applied to investigate the performance of a Savonius wind turbine equipped with deformable blades. They were continuously deformed during rotation by a dedicated mechanism to increase a positive torque of the advancing blade, and meanwhile, decrease a negative torque of the returning blade. A quasi-two-dimensional model with a two-way fluid-structure interaction method was applied, where the structural solver determined blade deflection caused by the predefined deformation mechanism and aerodynamic loads, whereas the coupled computational fluid dynamics solver determined the transient flow. The deformable blades rotor performance was calculated and compared with a conventional rigid Savonius turbine, both simulated using the overset mesh approach. The average value of the power coefficient achieved a 55% rise in the case of deformable blades turbine. Additionally, to validate the overset method, its results were compared with the classical sliding mesh method for a conventional rigid rotor.
    Źródło:
    Archives of Thermodynamics; 2021, 42, 4; 201-216
    1231-0956
    2083-6023
    Pojawia się w:
    Archives of Thermodynamics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sarcopenic Obesity as a Complication of Overweight and Obesity – a Summary of Knowledge
    Otyłość sarkopeniczna jako powikłanie nadwagi i choroby otyłościowej – podsumowanie wiedzy
    Autorzy:
    Jurgiel, Jan
    Karabin, Patryk
    Graniak, Adrianna
    Jóźwik, Konrad
    Opyd, Piotr
    Lis, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/29551936.pdf
    Data publikacji:
    2023
    Wydawca:
    Uczelnia Łazarskiego. Oficyna Wydawnicza
    Tematy:
    sarcopenic obesity
    obesity
    sarcopenia
    overweight
    otyłość sarkopeniczna
    choroba otyłościowa
    sarkopenia
    nadwaga
    Opis:
    The contemporary trend towards elevated consumption of processed food and a sedentary lifestyle has induced noticeable alterations in body composition observed in the population. These unprecedented changes have given rise to the emergence of novel pathological conditions, including sarcopenic obesity. This condition is characterized by an excessive accumulation of body fat in conjunction with skeletal muscle depletion and functional impairments. Diagnosis hinges upon a comprehensive evaluation of medical history and the performance of functional and imaging studies. The therapeutic strategy relies on the appropriate dietary regimen and increased physical activity. Current scientific research in the domain of sarcopenic obesity is advancing significantly, with potential pharmacotherapy involving novel weight-loss medications and other strategies addressing this health issue.
    Współczesny trend związany ze wzmożonym spożyciem wysoko przetworzonej żywności oraz prowadzeniem siedzącego trybu życia spowodował zauważalne zmiany w składzie ciała obserwowane w populacji. Te bezprecedensowe zmiany skutkują pojawieniem się nowych jednostek chorobowych, takich jak otyłość sarkopeniczna. Stan ten charakteryzuje się nadmiernym gromadzeniem tkanki tłuszczowej w połączeniu z utratą masy mięśniowej oraz ograniczeniami funkcjonalnymi. Postępowanie diagnostyczne opiera się na dokładnym wywiadzie lekarskim oraz przeprowadzeniu badań czynnościowych i obrazowych pozwalających na rozpoznanie tej patologii oraz wdrożenie odpowiedniego postępowania terapeutycznego opartego na zbilansowanej diecie i zwiększeniu aktywności fizycznej. Problematyka otyłości sarkopenicznej jest tematem wielu badań naukowych dotyczących możliwości farmakoterapii przy użyciu nowych leków redukujących masę ciała oraz innych strategii terapeutycznych.
    Źródło:
    Review of Medical Practice; 2023, XXIX, 3; 67-71
    2956-4441
    2956-445X
    Pojawia się w:
    Review of Medical Practice
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Numerical analysis of species diffusion and methanol decomposition in thermocatalytic reactor based on the Intermetallic phase of Ni3Al for low Reynolds numbers
    Autorzy:
    Ziółkowski, Paweł
    Stajnke, Michał
    Jóźwik, Paweł
    Bojar, Zbigniew
    Ziółkowski, Piotr Józef
    Badur, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1955275.pdf
    Data publikacji:
    2018
    Wydawca:
    Politechnika Gdańska
    Tematy:
    CFD
    thermocatalytic reactor
    intermetallic phase of Ni3Al
    Opis:
    Numerical modelling of hydrogen production by means of methanol decomposition in a thermocatalytic reactor using corrugated foil made of the Ni3Al intermetallic phase is shown in the paper. Experimental results of the flow analysis of mixtures containing helium and methanol in a thermocatalytic reactor with microchannels were used for the initial calibration of the CFD calculations (calculations based on the Computational Fluid Dynamics method). The reaction of the thermocatalytic methanol decomposition was modelled based on experimental data, considering the size of the active surface. The drop in the methanol concentration at the inlet to the reactor, ten millimetres in front of the thermocatalytic region, is associated with the diffusion of streams of other components, mainly hydrogen and carbon monoxide. The commercial CFD code was expanded by User Defined Functions (UDFs) to include surface chemical reaction rates in the interphase between the fluid and the solid. Extrapolation of data by means of the implemented numerical model enabled the assessment of the minimum length of microreactor channels and prediction of the optimal dimension at the system outlet. The results obtained by means of numerical calculations were calibrated and compared with the experimental data, confirming a satisfactory consistency of the data.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2018, 22, 3; 211--224
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mathematical modeling of hydrogen production performance in thermocatalytic reactor based on the intermetallic phase of Ni3Al
    Autorzy:
    Badur, Janusz
    Stajnke, Michał
    Ziółkowski, Paweł
    Jóźwik, Paweł
    Bojar, Zbigniew
    Ziółkowski, Piotr Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/240134.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    thermal decomposition
    species transport
    catalyst
    CFD
    rozkład termiczny
    katalizator
    Opis:
    The main goal of the considered work is to adjust mathematical modeling for mass transfer, to specific conditions resulting from presence of chemical surface reactions in the flow of the mixture consisting of helium and methanol. The thermocatalytic devices used for decomposition of organic compounds incorporate microchannels coupled at the ends and heated to 500ºC at the walls regions. The experiment data were compared with computational fluid dynamics results to calibrate the constants of the model’s user defined functions. These extensions allow to transform the calculations mechanisms and algorithms of commercial codes adapting them for the microflows cases and increased chemical reactions rate on the interphase between fluid and solid, specific for catalytic reactions. Results obtained on the way of numerical calculations have been calibrated and compared with the experimental data to receive satisfactory compliance. The model has been verified and the performance of the thermocatalytic reactor with microchannels under hydrogen production regime has been investigated.
    Źródło:
    Archives of Thermodynamics; 2019, 40, 3; 3-26
    1231-0956
    2083-6023
    Pojawia się w:
    Archives of Thermodynamics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of Torsional Strength of Pa2200 Material Shape Additively with the Selective Laser Sintering Technology
    Autorzy:
    Bernaczek, Jacek
    Dębski, Mariusz
    Gontarz, Małgorzata
    Grygoruk, Roman
    Józwik, Jerzy
    Kozik, Bogdan
    Mikulski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/2201927.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    torsional strength
    PA2200 powder
    additive manufacturing
    SLS technology
    SLS
    Selective Laser Sintering
    optical measurements
    3D scanning
    Opis:
    The purpose of the undertaken research work is to analyze the torsional strength of standard samples with a circular cross-section, produced additively using the SLS (Selective Laser Sintering) technique – sintering PA2200 polyamide powders. The studies conducted so far have not included a static torsion test, the results of which are crucial for parts such as machine shafts, hubs, couplings, etc. Hence the idea of conducting the research in question. The samples were made in different settings relative to the machine's working platform and subjected to post-processing in two variants – by water-soaking and furnace-heating – in order to determine the influence of the orientation of the model in the manufacturing process and the type of post-processing on torsional strength. The produced samples were additionally subjected to a preliminary dimensional and shape verification due to the significant impact of the accuracy of the models in the SLS process on the operation of the above-mentioned machine parts. Based on the analysis of the test results, it was found that the highest torsional strength was determined for the furnace-heated samples. In addition, the highest mapping accuracy was found for models positioned vertically in relation to the machine's working platform.
    Źródło:
    Advances in Science and Technology. Research Journal; 2023, 17, 2; 12--24
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhaled drug airflow patterns and particles deposition in the paediatric respiratory tract
    Autorzy:
    Tyfa, Zbigniew
    Jóźwik, Paulina
    Obidowski, Damian
    Reorowicz, Piotr
    Jodko, Daniel
    Kapka, Krystyna
    Makosiej, Ryszard
    Czkwianianc, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/27324137.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    patient-specific model
    particle tracking
    inhaled drug
    airflow CFD simulation
    paediatric respiratory tract
    śledzenie cząstek
    lek wziewny
    symulacja CFD przepływu powietrza
    respirator dziecięcy
    Opis:
    : The effectiveness of inhaled drugs is strictly related to areas reachable by drug particles. Unless particles reach the desired part of the bronchial tree, their influence might not meet the expectations. Consequently, the disease progress might not be stopped or even slowed down. Therefore, the primary objective of this research was to analyze the airflow patterns and particle deposition of a standard inhaled drug using computational fluid dynamics. Methods: The study was devoted to the analysis of the particle diameter influence on their deposition areas within the entire respiratory tract. Two patient-specific respiratory tract models, for 6 and 12-year-old patients, were reconstructed based on the computed tomography examinations. Numerical analyses were carried out as stationary ones with the constant inflow of the particles of various diameters (within the range of 1–50 μm). It was proven that depending on the particle size, their deposition within the respiratory tract varies significantly. Results: The vast majority of the particles with diameters over 20 μm is gathered on the walls of the throat, whereas particles of diameters 5–15 μm are accumulated mainly on the trachea walls, leaving the alveoli insufficiently supplied with the drug particles. Conclusions: The inhaled drug size cannot be treated as negligible factor during the drug spraying. An improper distribution of the particles might not inhibit the symptoms of the asthma. Numerical simulations may improve drugs selection and visualize their distribution along the airways, which might accelerate asthma treatment personalization.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2020, 22, 2; 101--110
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Experimental investigations of the PMMA bone cement distribution inside a model of lumbar vertebrae
    Autorzy:
    Bonik, Artur
    Tyfa, Zbigniew
    Ciupik, Lechosław Franciszek
    Sobczak, Krzysztof
    Kierzkowska, Agnieszka
    Obidowski, Damian Stanisław
    Witkowski, Dariusz
    Pałczyński, Tomasz
    Elgalal, Marcin
    Komorowski, Piotr
    Słoński, Edward
    Jóźwik, Krzysztof
    Walkowiak, Bogdan
    Powiązania:
    https://bibliotekanauki.pl/articles/2232172.pdf
    Data publikacji:
    2022
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    percutaneous vertebroplasty
    osteoporotic spinal fractures
    spinal cement injection
    cement distribution
    bone cement preparation
    Opis:
    The use of bone cement in procedures such as vertebroplasty and kyphoplasty can reduce pain and mechanically support the spine. This study aimed to evaluate whether air entrapped within bone cement affected its distribution in a vertebral body model. The study included 3D printed anatomical models of vertebrae together with their internal trabecular structure. Aeration was achieved by mixing the bone cement using three different altered procedures, whilst the control sample was prepared according to the manufacturer’s instructions. The further two samples were prepared by reducing or increasing the number of cycles required to mix the bone cement. A test rig was used to administer the prepared bone cement and introduce it into the vertebral model. Each time the injection was stopped when either the cement started to flow out of the vertebral model or when the entire cement volume was administered. The computer tomography (CT) scanning was performed to evaluate aerification and its influence on the bone cement distribution in each of the patient-specific models. The large number of small pores visible within the cement, especially in the cannula vicinity, indicated that the cement should not be treated as a homogenous liquid. These results suggest that a high level of aerification can influence the further cement distribution.
    Źródło:
    Engineering of Biomaterials; 2022, 25, 165; 23--30
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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