Autor: Ilie, Petre - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A paradigm shift in the role of NSAIDs in COVID-19: new pathological mechanisms and potential treatment targets
Autorzy:: Ilie, Petre Cristian
Stefanescu, Simina
Veronese, Nicola
Powiązania:: https://bibliotekanauki.pl/articles/1491092.pdf
Data publikacji:: 2020-09-20
Wydawca:: Atena Research Association
Tematy:: Paradigm Shift
NSAIDs
Covid-19
COX-2 inhibitors
Opis:: Objectives: The pathogeny of SARS-COV2 infection is currently not well defined. In this paper, we present a new perspective of how the SARS-CoV2 infection can lead to severe cases and potential pathways of preventing such cases. Methods: In the first part, we describe the role of cyclooxigenase 2 and in the second part, we describe the role of hypoxia inducible factor (HIF). Findings: We hypothesize that cyclooxigenase 2 and hypoxia inducible factor with subsequent inflammation and hypoxia can up-regulate each other in a vicious circle of feed-forward that can ultimately lead to “cytokine storm”. Conclusions: Breaking this cycle early potentially will have beneficial effects either by improving oxygenation (oxygen being given earlier in the course of the treatment) or by inhibiting COX-2. We also believe, that the use of COX-2 inhibitors early in the course of the disease can improve the outcome and clinical trial are urgently needed.
Źródło:: Atena Journal of Public Health; 2020, 2; 6-6
2695-5911
Pojawia się w:: Atena Journal of Public Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Risk behaviours associated with hepatitis C infection: application of a syndemic effects framework in NHANES
Autorzy:: Stefanac, Sinisa
Haider, Sandra
Dorner, Thomas
McDermott, Daragh
Ilie, Petre
Powiązania:: https://bibliotekanauki.pl/articles/1491142.pdf
Data publikacji:: 2021-04-05
Wydawca:: Atena Research Association
Tematy:: Hepatitis C Virus
Syndemic
Intravenous Drug Use
Risk
Disparity
Opis:: Objectives: To apply syndemic theory to investigate the risk of hepatitis C virus (HCV) infection in the US population. Methods: National representative data were from the National Health and Nutrition Examination Survey. We extracted and aggregated data on HCV antibody test, sociodemographic characteristics, alcohol and drug use, depression, sexual behaviour and sexually transmitted illnesses from 2005-2006 to 2011-2012. The study sample was restricted to men and women aged 20-59 years given the upper age limit of the risk factors used for the analysis. Results: Overall, 11,593 people were included in the analysis (52.2% female). Higher prevalence of HCV, excessive alcohol consumption and drug use were found in men. Men also had higher odds of HCV in comparison to women among younger (20-39 years old) OR 1.37 (95%CI 1.36-1.37) and middle-aged adults (40-59 years old) OR 2.04 (95%CI 2.03-2.04). Among younger adults, non-Hispanic black and Hispanic people were found to have a lower likelihood of testing positive, OR 0.35 (95%CI 0.35-0.35) and OR 0.30 (95%CI 0.30-0.30), respectively. However, in the middle-aged adults non-Hispanic black people were found to have a higher likelihood of testing positive OR 1.45 (95%CI 1.45-1.46). Analysis showed that for each additional risk factor associated with HCV infection there is an additional increase in the risk OR 1.55 (95%CI 1.55-1.55). Conclusions: For every additional risk factor for HCV a person is exposed to, the overall risk of HCV increases.
Źródło:: Atena Journal of Public Health; 2021, 3; 5-5
2695-5911
Pojawia się w:: Atena Journal of Public Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Sexual intercourse and sleep in older age: findings from the English Longitudinal Study of Ageing
Autorzy:: Grabovac, Igor
Pizzol, Damiano
McDermott, Daragh T.
Swami, Viren
Ilie, Petre Cristian
Forwood, Suzanna
Yang, Lin
Powiązania:: https://bibliotekanauki.pl/articles/1491181.pdf
Data publikacji:: 2020-10-25
Wydawca:: Atena Research Association
Tematy:: Older adults
sexual activity
sexual intercourse
sleep duration
sleep quality
Opis:: Objectives: To investigate associations between sexual intercourse and sleep quality and duration, controlling for a range of confounders, in a large, representative sample of older English adults. Methods: Data were from 2,743 men and 2,990 women aged ? 50 years, participating in the English Longitudinal Study of Ageing. Participants reported whether or not they had engaged in sexual activity in the last year, and those who were sexually active reported frequency of intercourse in the past month. Information on sleep disturbance and duration and socio-demographic and health-related covariates was also collected. Findings: Being sexually active was not associated with sleep disturbance or sleep duration. Men who had less frequent intercourse reported greater sleep disturbance than those who reported no sexual intercourse (OR=1.29, 95% CI 1.02-1.65), but had lower odds of reporting longer than optimal sleep duration (OR=0.45, 95% CI 0.24-0.86). Men who engaged in sexual intercourse once a week or more (OR=0.43, 95% CI 0.23-0.80) also had lower odds of long sleep relative to those who reported no sexual intercourse. Women who engaged in more frequent (? once a week) intercourse reported less sleep disturbance than those who reported no sexual intercourse in the last month (OR=0.68, 95% CI 0.53-0.86), and women who reported sexual intercourse once in the past month had lower odds of long sleep (OR=0.51, 95% CI 0.26-0.996). Conclusions: In a population-based sample of older men and women in England, there was inconsistent evidence of an association between sexual activity and sleep disturbance and sleep duration.
Źródło:: Atena Journal of Public Health; 2021, 3; 1-1
2695-5911
Pojawia się w:: Atena Journal of Public Health
Dostawca treści:: Biblioteka Nauki

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