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    Wyświetlanie 1-3 z 3
    Tytuł:
    CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells
    Autorzy:
    Łuczyński, Włodzimierz
    Stasiak-Barmuta, Anna
    Iłendo, Elżbieta
    Krawczuk-Rybak, Maryna
    Malinowska, Iwona
    Mitura-Lesiuk, Małgorzata
    Parfieńczyk, Adam
    Szymański, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1041252.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunotherapy
    T-lymphocytes
    CD40L
    acute lymphoblastic leukemia
    dendritic cells
    Opis:
    Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory molecules and are poor antigen presenting cells (APCs) for T-cell activation. CD40/40L interaction stimulates B-cells to proliferate, differentiate, upregulate costimulatory molecules and increase antigen presentation. The aim of the study was to test the hypothesis that ALL cells can be turned into professional APCs by CD40L activation. Children with B-cell precursor ALL were enrolled into the study. Mononuclear cells from bone marrow or peripheral blood were stimulated with CD40L and interleukin 4. Results: 1) after culture we noted upregulation of all assessed costimulatory, adhesion and activatory molecules i.e. CD1a, CD11c, CD40, CD54, CD80, CD83, CD86, CD123, HLA class I and II; 2) CD40L activated ALL cells induced proliferation of allogeneic T-cells (measured by [3H]thymidine incorporation). These results confirm the possibility of enhancing the immunogenicity of ALL cells with the CD40L system and indicate that this approach can be used in immunotherapeutic trials.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 2; 377-382
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes
    Autorzy:
    Łuczyński, Włodzimierz
    Wawrusiewicz-Kurylonek, Natalia
    Stasiak-Barmuta, Anna
    Urban, Remigiusz
    Iłendo, Elżbieta
    Urban, Mirosława
    Hryszko, Marek
    Krętowski, Adam
    Górska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1040597.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunotherapy
    T-lymphocytes
    autoimmunity
    FoxP3
    Opis:
    Diabetes mellitus is one of the most common chronic diseases in children. T regulatory cells (Tregs) modulate response to autoantigens and probably play a role in pathogenesis of type 1 diabetes (T1DM). The aim of the present study was the assessment of T regulatory cells including their percentages and expression of critical genes in these cells in children with newly diagnosed type 1 diabetes. The examined group consisted of 50 children with T1DM. A flow cytometric analysis of T-cell subpopulations was performed using the following markers: anti-CD4, anti-CD25 and anti-CD127 (=IL-7R). Additionally, T regulatory cells were isolated for assessment of mRNA levels for chosen genes with the real-time RT-PCR technique. The percentages of CD4+CD25highCD127dim/- were very low and did not differ between T1DM and control children. We did not observe any statistically significant differences between healthy and diabetic children in mRNA expression for FoxP3, IL-7R (CD127), IL-8RA, IL-10RA, IL-12A, IL-2RA (CD25), IL-21, STAT1, STAT3, SOCS2, SOCS3, TGF-β1-R1, TGF-β-R2 and TBX-21 genes. Interestingly the mRNA level for CTLA-4, ICOS1, IL-23, IL-27, SMAD3 and GITR were lower in Treg cells of children with diabetes compared to the control patients. No disturbances in the percentages of T regulatory cells in patients with diabetes but diminished expression of some elements important in Treg function could be the result of an immunologic imbalance accompanying the onset of the diabetes. The results of our study should be used in future research in the field of immunotherapy in pediatric diabetes.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 2; 361-370
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stan cywilny dziecka jako potwierdzenie przynależności do rodziny
    Civil status of child as confirmation of belonging to the family
    Autorzy:
    Makarewicz, Elżbieta
    Iłendo-Milewska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/621906.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
    Tematy:
    stan cywilny, dziecko, rodzina, potrzeba przynależności.
    civil status, child, family, the need to belong.
    Opis:
    The article contains theoretical considerations in the field of law and psychological sci- ences concerning the civil status of the child who is shown as a member of a social group – family. The legal situation of the child is described on the basis of legal regulations and conventions being in force in Poland. The article concerns the concept of the family, parenting, motherhood and fatherhood, in the context of dynamically evolving relation- ships and social situations, which are not always described by law. These concepts are shown in the context of the guarantee function of the state expressed in the catalogue of rules of social coexistence aimed at the determination of the boundaries between the sphere of dominion and individual freedom. The main scientific problem presented in this article, which is “what is the correlation between the compliance of the civil status and the belonging to the family?”, was presented in the light of the knowledge of the law and psychological theories referring to numerous studies. The article describes J. Bowl- by’s attachment theory (1988) and the styles of attachment by M. Ainsworth (1978). It is assumed that the knowledge of the factors or elements which determine the need to belong to the family still seems to be an important issue and raises the question whether the child’s status is one of them. This article contains theoretical considerations and im- plications beginning the research project and constituting the introduction to scientific discussion. If the welfare of the child requires to pursue the compliance of marital status confirmed by a civil status act with the real belonging to the family, then it is very impor- tant for the family to satisfy the need for affiliation of the child and provide the quality of its functioning. It is assumed that the type of interaction between the child and parents can be reflected by the type of attachment.
    Źródło:
    Miscellanea Historico-Iuridica; 2016, 15, 1; 317-337
    1732-9132
    2719-9991
    Pojawia się w:
    Miscellanea Historico-Iuridica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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