- Tytuł:
- Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells
- Autorzy:
-
Jung, Kyung
Ha, Eunyoung
Kim, Mi-Ja
Uhm, Yoon
Kim, Hye
Hong, Seung-Jae
Chung, Joo-Ho
Yim, Sung-Vin - Powiązania:
- https://bibliotekanauki.pl/articles/1041224.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
Ganoderma lucidum extract
skeletal muscle
phosphatidylinositol 3-kinase
AMP-activated protein kinase
glucose uptake - Opis:
- The effect of Ganoderma lucidum extract on glucose uptake was studied in L6 rat skeletal muscle cells. G. lucidum extract increased glucose uptake about 2-fold compared to control. The extract stimulated the activity of phosphatidylinositol (PI) 3-kinase which is a major regulatory molecule in the glucose uptake pathway. About 7-fold increased activity of a PI 3-kinase was observed after treatment with G. lucidum extract, whereas PI 3-kinase inhibitor, LY294002, blocked the G. lucidum extract-stimulated PI 3-kinase activity in L6 skeletal muscle cells. Protein kinase B, a downstream mediator of PI 3-kinase, was also activated by G. lucidum extract. We then assessed the activity of AMP-activated protein kinase (AMPK), another regulatory molecule in the glucose uptake pathway. G. lucidum extract increased the phosphorylation level of both AMPK α1 and α2. Activity of p38 MAPK, a downstream mediator of AMPK, was also increased by G. lucidum extract. Taken together, these results suggest that G. lucidum extract may stimulate glucose uptake, through both PI 3-kinase and AMPK in L6 skeletal muscle cells thereby contributing to glucose homeostasis.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 3; 597-601
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł