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Wyszukujesz frazę "Heleniak, Zbigniew" wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Aliskiren reduces albuminuria after kidney transplantation
Autorzy:
Tylicki, Leszek
Debska-Slizien, Alicja
Lizakowski, Slawomir
Przybylska, Milena
Heleniak, Zbigniew
Renke, Marcin
Chamienia, Andrzej
Biedunkiewicz, Bogdan
Rutkowski, Przemyslaw
Małgorzewicz, Sylwia
Rutkowski, Boleslaw
Powiązania:
https://bibliotekanauki.pl/articles/1038634.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
albuminuria
aliskiren
kidney transplantation
renoprotection
Opis:
Background: The renoprotective effects of the direct renin inhibitor, aliskiren, in renal transplant recipients have been supposed, but not finally proven. We performed an exploratory double-blind, losartan controlled, cross-over study to evaluate the influence of aliskiren, direct renin inhibitor, on albuminuria and other surrogate markers of kidney injury in patients after renal transplantation. The safety of this therapy was also evaluated. Method: 16 of 18 patients (12 M, 4 F), 48.3 ± 9.0 years, 57.7 ± 9.1 months after kidney transplantation, with hypertension and stable serum creatinine 1.4 ± 0.08 mg/dl without proteinuria, completed the protocol. Each patient underwent two 8-week treatment periods (one with 150 mg of aliskiren, and one with 50 mg of losartan) in random order, allowing an 8-week placebo washout between them. Results: There were no differences in albuminuria, transforming growth factor β-1 and 15-F2t-isoprostanes urine excretion between aliskiren and losartan. Creatinine serum level, eGFR, 24 h systolic and 24 h diastolic blood pressure were stable through the study. There were no differences in haemoglobin and potassium serum concentration between studied drugs. Conclusion: Aliskiren decreases albuminuria in renal transplant recipients with clinically minimal side effects. The effect does not differ from that of losartan.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 221-226
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Internet searching may predict novel symptoms, but not new outbreaks. A long-term evaluation of infoveillance in COVID-19
Autorzy:
Radziwon, Jakub A.
Lubiejewski, Maciej
Waszak, Przemysław
Heleniak, Zbigniew
Dębska-Ślizień, Maria A.
Powiązania:
https://bibliotekanauki.pl/articles/25710189.pdf
Data publikacji:
2023-11-09
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
Prediction
COVID-19
Infodemiology
Opis:
Background: At the beginning of COVID-19 pandemic authors in several countries reported the possibility of predicting disease outbreaks using internet analysis and search tools like GoogleTrends™. Our aim was to investigate the impact of changes in COVID-19 symptomatology and pandemic intensity on those predictions. Material and methods: GoogleTrends™ was utilized to track online searches for COVID-19 symptoms in Poland during two years of the pandemic. Search volumes were then assessed for correlation with daily cases in each wave of infection separately. Results: The symptoms that correlated strongly with new cases were anosmia and ageusia (Spearman's rho=0.5230 and rho=0.4483 respectively, p<0.01). Searches for these symptoms preceded an outbreak by 12 days during the first wave of infections, but this gap was later shortened to five days. The frequency of searching for these symptoms markedly diminished during the last phase and was no longer adequate. Stronger correlations were then shown for fever, sore throat, and headache. Conclusions: In conclusion, COVID-19 case prediction using GoogleTrends™ did not remain possible later on in the pandemic course. However, noticeable changes reflecting novel features of emerging SARS-CoV-2 variants were observed. Therefore, monitoring symptom changes and virus evolution might be a promising application of internet search analysis in the future.
Źródło:
European Journal of Translational and Clinical Medicine; 2023, 6, 2; 71-77
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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