Autor: Grzanka, Alina - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Białka kompleksu ADF/kofilina: regulacja dynamiki filamentów aktynowych
Proteins of the ADF/cofilin family: regulation of actin filaments dynamics
Autorzy:: Stępień, Aleksandra
Grzanka, Alina
Ostrowski, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1198687.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Many cellular events are directly related to the cytoskeleton’s dynamics, which remain under control of the protein regulatory system. Proteins of the ADF/cofilin family have been shown to be active in depolymerizing F-actin, as well as severing actin filaments and creating free barbed ends. Their various functions are regulated, among others, by phosphorylation, pH, the state of the nucleotide bound profilin, gelsolin, tropomyosin, AIP1 and the Arp 2/3 complex. In addition, the ability of ADF/cofilin to bind to actin appears to be modified by phalloidin. It has also been emphasized that these key actin dynamics’ regulators are able to form intranuclear actin/cofilin rods and some of their activities are associated with apoptosis.
Źródło:: Kosmos; 2005, 54, 4; 381-389
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Rak pęcherza moczowego - molekularne podłoże genezy i leczenia
Bladder cancer - molecular basis of genesis and therapy
Autorzy:: Izdebska, Magdalena
Grzanka, Alina
Ostrowski, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1198597.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Bladder cancer is one of the most common human tumours.This malignancy develops in various tissues of the bladder. The disease is caused by several factors e.g. some chemical agents and radiation. Ingredients of smoke and numerous industrial chemicals play a role in cancer cells formation. Aromatic amines and some their derivatives introduce changes in DNA sequences. Mutations of some suppressor genes and protooncogenes (p53, Rb) may contribute to tumour transformation. Mitomycin C, adriamycin and other chemiotherapeutics destroy cancer cells acting on plasma membrane and mitochondrial apoptotic pathways. This review article presents the molecular basis of formation and of the mechanisms of urinary bladder.
Źródło:: Kosmos; 2005, 54, 2-3; 213-220
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Kompleks Arp2/3 jako kluczowy czynnik polimeryzacji aktyny
The Arp2/3 complex as a key factor of actin polymerization
Autorzy:: Litwiniec, Anna
Grzanka, Alina
Stępień, Aleksandra
Powiązania:: https://bibliotekanauki.pl/articles/1198511.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Przyrodników im. Kopernika
Opis:: Directed motility of the cell is strictly dependent on regulation of the assembly/disassembly of actin filaments. New formed „daughter” filaments press against the membrane, thus generating a protrusive force, which is necessary for the initial stage of the movement. Precisely ordered geometry of „dendritic actin brush” results from the action of the Arp2/3 complex i. e. actin polymerization. The complex composition of seven evolutionarily conserved subunits among Eucaryota indicates the uniformity of its biological functions in the cell. Consequently, the Arp2/3 complex plays an important role not only in many physiological processes, such as embroygenesis, development of tissues, inflammatory response, wound healing, but also in propagating themselves of some intracellular pathogens through of the host’s plasma. Moreover, it has been shown, that the most suitable model of the Arp2/3 complex function is „the dendritic nucleation model”. The emerging issues requiring explanation seem to be interactions of individual subunits with each other, with „mother” and „daughter” filament, as well as with nucleation promoting factors, in the process of actin polymerization according to this model.
Źródło:: Kosmos; 2006, 55, 2-3; 287-293
0023-4249
Pojawia się w:: Kosmos
Dostawca treści:: Biblioteka Nauki

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