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Wyszukujesz frazę "Gryko, K." wg kryterium: Autor


Wyświetlanie 1-6 z 6
Tytuł:
Comparison of expression of selected proteins in the cells of intestinal and diffuse type gastric cancer – immunohistochemical analysis
Autorzy:
Gryko, M.
Prycznicz, A.
Dawidziuk, T.
Zińczuk, J.
Cepowicz, D.
Kamocki, Zb.
Kedra, B.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1916399.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
gastric cancer
apoptosis
Lauren classification
E-cadherin
apoptotic pathways
Opis:
Introduction: Despite the progress in gaining knowledge about carcinogenesis, it is still unclear what processes are directly responsible for the differentiation of gastric cancer into its intestinal or diffuse form. Dividing of these two forms is based on one of the oldest, yet still commonly used classifications – the classification of Lauren. There are many factors that may influence the formation of gastric tumors of various aggressiveness. Purpose: To evaluate the expression of proteins: fragile histidine triad (FHIT), E-cadherin, α-catenin, γ-catenin, cathepsin B, epidermal growth factor (EGF), HER-2, MMP-9, MCM-2, Bak, Bax, BID, Bcl-XL, p53, FasL, Bcl-2, caspase-8, procaspase-3 in gastric cancer cells, depending on the type of tumor by Lauren classification. Materials and methods: Study group consisted of 91 patients treated surgically for gastric cancer in the Second Department of General and Gastroenterological Surgery, Medical University of Bialystok in years between 2000 and 2006. Results: It is shown, that the expression of E-cadherin was significantly higher in the Lauren I gastric cancer cells than in Lauren II. In case of caspase-8 there has been significantly less frequent expression of this protein in Lauren I gastric cancer cells compared to Lauren II. The authors describe no statistically significant differences in the expression of other proteins taken into consideration. Conclusions: These results suggest the role of adhesion and apoptosis-related proteins in the development of two different types of gastric cancer according to Lauren’s classification.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 158-164
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hiatus hernia – Late complication after gastrectomy followed by double tract reconstruction (DTR): a case report
Autorzy:
Bandurski, R.
Gryko, M.
Dawidziuk, T.
Zaręba, K.
Cepowicz, D.
Kędra, B.
Powiązania:
https://bibliotekanauki.pl/articles/1916509.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
gastric cancer
hiatus hernia
late complication
surgery
Opis:
In patients with dyspeptic symptoms who have been treated for gastric cancer, other medical conditions apart from cancer recurrence should be considered. A long small-bowel loop left after esophagogastric anastomosis, flaccid diaphragmatic crura, and several external factors such as hard physical exertion can promote the development of postoperative hiatus hernia. The authors of this paper present a rare case of hiatus hernia considered a late complication of primary surgery performed due to gastric cancer. The 63-year-old patient had undergone total gastrectomy with double tract reconstruction (DTR) six years earlier. Gastrectomy was performed with extended lymphadenectomy (>D2). Histopathologic examination of tumor specimens showed mucinous adenocarcinoma with no lymph node metastasis and no distant metastases (pathologic staging: pT2, pN0, pM0). After six years, the patient was admitted to the 2nd Department of General and Gastroenterologic Surgery with abdominal pains, malaise, weight loss and feeling of fullness after small meals. Diagnostic procedures performed showed the presence of hiatus hernia, a very rare complication after this particular surgery, with no features of cancer recurrence. The patient was underwent surgery and the hernia was successfully repaired.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 265-268
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of apoptosis-related proteins in patients with ulcerative colitis
Autorzy:
Niewiarowska, K.
Lebelt, A.
Gryko, M.
Pryczynicz, A.
Famulski, W.
Czyżewska, J.
Kemona, A.
Piekarska-Dymicka, V.
Jagodzińska, D.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1916338.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Ulcerative colitis
Bcl-xl
Bax
Bid
Bcl-2
Opis:
Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 75-82
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical usefulness of MMP-2 and TIMP-2 concentrations in the preoperative serum of patients with colorectal cancer
Autorzy:
Pryczynicz, A.
Gryko, M.
Dymicka-Piekarska, V.
Lewczuk, Ł.
Wakulewska, A.
Ozimkiewicz, M.
Lebelt, A.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1917768.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Colorectal cancer
matrix metalloproteinases
MMP-2
TIMP-2
serum marker
Opis:
Purpose: To evaluate the clinical significance of MMP-2 and TIMP-2 concentrations in the sera of patients diagnosed with colorectal cancer. Methods: The study group comprised 48 patients with colorectal carcinoma and 24 healthy controls. The serum concentration of MMP-2 and TIMP-2 proteins was evaluated by the ELISA method. Results: The mean level of MMP-2 in the sera of patients with colorectal cancer was 39.4 ng/ml and was significantly lower compared with the control (p<0.001). A decrease in TIMP-2 protein in the sera of patients with colorectal cancer was also observed where its mean level was 132.3 ng/ml. The concentration of MMP-2 and TIMP-2 did not correlated with any clinicopathological parameters, except for the patients’ age. In addition, the concentration of MMP-2 in the sera of patients with CRC correlated negatively with the number of white blood cells in the blood and the prothrombin index. The concentration of TIMP-2 correlated positively with potassium and urea concentration in the blood. Conclusions: The results of our study indicate lack of clinical usefulness of determining the levels of MMP-2 and TIMP-2 in the sera of patients with colorectal cancer. However, these proteins play an important role in the carcinogenesis of colorectal cancer.
Źródło:
Progress in Health Sciences; 2016, 6(1); 32-39
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microarrays - new possibilities for detecting biological factors hazardous for humans and animals, and for use in environmental protection
Autorzy:
Mirski, T.
Bartoszcze, M.
Bielawska-Drozd, A.
Gryko, R.
Kocik, J.
Niemcewicz, M.
Chomiczewski, K.
Powiązania:
https://bibliotekanauki.pl/articles/51516.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Somatotype variables related to strength and power output in male basketball players
Autorzy:
Buśko, K.
Pastuszak, A.
Lipińska, M.
Gryko, K.
Powiązania:
https://bibliotekanauki.pl/articles/306234.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
mężczyzna
koszykówka
somatotyp
siła
skok
male
basketball
Somatotype
strength
power
vertical jump
Opis:
The purpose of this study was to investigate the relationship between somatotype, muscular strength, power output measured in maximal cycle ergometer exercise bouts, and maximal power output and height of rise of the body mass centre (jump height) measured in akimbo counter movement jump (ACMJ), counter movement jump (CMJ) and spike jump (SPJ), in male basketball players. Methods: Thirteen male basketball players (second division, age 19.4±0.8 years, body height 192.9±5.6 cm, body mass 88.8±8.6 kg, training experience 9.3±0.8 years) participated in the study. Somatotype was determined using the Heath-Carter method. Maximal joint torques were measured under static conditions. Power output was measured in 2 maximal cycle ergometer exercise bouts, 10 s each, with increasing external loads equal to 7.5 and 10.0% of the body weight (BW). All jump trials (ACMJ, CMJ and SPJ) were performed on a force plate. Results: The mean somatotype of basketball players amounted to: 2.8-4.2-3.2. Sum of the joint torques for left and right lower extremities (0.613), trunk (0.631) and all six measured muscle groups (0.647) were significantly correlated (p<0.05) with mesomorphy and ectomorphy. Conclusion: It can be assumed that basketball players’ anthropometric characteristics can influence their level of performance but it is not a decisive factor.
Źródło:
Acta of Bioengineering and Biomechanics; 2017, 19, 2; 161-167
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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