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    Tytuł:
    The study of cell and tissue mechanisms of the homeostasis of helminth-host system at muscle trichinellosis before and after the administration of a herb biostimulator and anthelminthic
    Autorzy:
    Movsessian, S
    Goncharova, G.
    Asatrian, A.
    Nikoghossian, M.
    Malczewski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/839244.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    herb
    host-parasite system
    anthelminthic treatment
    muscle
    homeostasis
    trichinellosis
    phytotherapy
    tissue mechanism
    helminth parasite
    cellular mechanism
    Trichinella spiralis
    host
    Opis:
    Results of micromorphological and histological studies of larvae of Trichinella Spiralis and T. pseudospiralis, as weil as, muscles, liver and small intestine of the rat-host before and after biostimulator administration of phytohemagglutinin and phytoanthelminthic were presented. It has been established that rats with Trichinella larvae of both species developed unspecific allergic angiomyositis, hepatitis, cholangitis, and erosio-haemorrhagic enterocolitis in the host's organism on the 35th day after infection. Furthermore, processes of compensatory hypertrophy, that support the host's (rats) homeostasis, on cell and tissue levels, were observed at histodestructional and morphofunctional deficiency. lt has been revealed that phytohemagglutinin, biostimulator injected into the host's organism before infection, is of immunostimulating nature and partially destroys the larvae of Trichinella. The phytoanthelminthic produces a significant trichinellocide effect: RNA synthesis and glycogen is intensified in the organs of the treated animals, their pathomicromorphogenesis weakened, and their compensatory and regenerative processes were observed. The combined use of the phytohemagglutinin and phytoanthelminthic fails to intensify the mentioned effect.
    Źródło:
    Annals of Parasitology; 2003, 49, 2
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The study of cell and tissue mechanisms of the homeostasis of helminth-host system at muscle trichinellosis before and after the administration of a herb biostimulator and anthelminthic
    Autorzy:
    Movsessian, S.
    Goncharova, G.
    Asatrian, A.
    Nikoghossian, M.
    Malczewski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147629.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    herb
    host-parasite system
    anthelminthic treatment
    muscle
    homeostasis
    trichinellosis
    phytotherapy
    tissue mechanism
    helminth parasite
    cellular mechanism
    Trichinella spiralis
    host
    Opis:
    Results of micromorphological and histological studies of larvae of Trichinella Spiralis and T. pseudospiralis, as weil as, muscles, liver and small intestine of the rat-host before and after biostimulator administration of phytohemagglutinin and phytoanthelminthic were presented. It has been established that rats with Trichinella larvae of both species developed unspecific allergic angiomyositis, hepatitis, cholangitis, and erosio-haemorrhagic enterocolitis in the host's organism on the 35th day after infection. Furthermore, processes of compensatory hypertrophy, that support the host's (rats) homeostasis, on cell and tissue levels, were observed at histodestructional and morphofunctional deficiency. lt has been revealed that phytohemagglutinin, biostimulator injected into the host's organism before infection, is of immunostimulating nature and partially destroys the larvae of Trichinella. The phytoanthelminthic produces a significant trichinellocide effect: RNA synthesis and glycogen is intensified in the organs of the treated animals, their pathomicromorphogenesis weakened, and their compensatory and regenerative processes were observed. The combined use of the phytohemagglutinin and phytoanthelminthic fails to intensify the mentioned effect.
    Źródło:
    Wiadomości Parazytologiczne; 2003, 49, 2; 195-217
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel potential of pancreatic-like enzymes of microbial origin in exocrine pancreatic insufficiency - study on a pig model
    Autorzy:
    Szwiec, K.
    Goncharova, K.
    Velverde-Piedra, J.L.
    Ushakova, G.
    Kovalenko, T.
    Osadchenko, I.
    Kardas, M.
    Swieboda, P.
    Podgurniak, P.
    Winiarczyk, M.
    Grochowska-Niedworok, E.
    Lozinska, L.
    Filip, R.
    Pierzynowski, S.G.
    Powiązania:
    https://bibliotekanauki.pl/articles/3181.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    pancreatic-like enzyme
    microbial enzyme
    exocrine pancreatic insufficiency
    porcine model
    pig
    animal model
    enzyme activity
    Opis:
    Introduction. The standard porcine-derived pancreatic enzyme replacement therapy (PERT) is a lifesaving treatment for patients with diseases causing exocrine pancreatic insufficiency (EPI). An attempt to replace PERT with microbial enzymes were undertaken. The aim was to highlight whether the mode of application, mixed with food or applied directly to the stomach, of pancreatic-like enzymes of microbial origin (PLEM) can affect their activity along the gastrointestinal tract. Materials and method. The activity of amylase, lipase and proteinase in the stomach, duodenum and ileum were tested in EPI pigs (n=6) after supplementation of PLEM, either orally – before and during feed consumption – or via the stomach – before and during feed consumption. Healthy pigs not treated with PLEM (n=3) served as controls. Activity of the enzymes measured in the chyme were obtained together with the digesta pH. Activity of the enzymatic residues in the stool samples was also checked. Results. The highest pancreatic enzyme activities were found in the duodenum of the healthy pigs (amylase 162,68 kU/ mL, lipase 507,34 kU/mL and protolitic (trypsin) activity 357,60 kU/mL). Nevertheless, the microbial enzymes remained also active along the entire length of the GIT – including stomach in EPI pigs, regardless of their route of administration. However, activity level was significantly lower. Discussion. Results indicate that the activity pattern of PLEM in the small intestine mimics the activity of the natural endogenous pancreatic enzymes in healthy pigs. The most physiological features of PLEM were observed when enzymes were offered orally. The magnitude of PLEM activity in the stomach of EPI pigs was essential and significantly higher than that measured in healthy pigs, thus being somewhat not physiological, and for health reasons of the patients should be further explored. Interestingly, specific trypsin-like activity was measured in all parts of the GIT after PLEM application. However, proteolytic activity of the experimental proteaze in in vitro studies did not exhibit trypsin-like activity.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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