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    Wyświetlanie 1-3 z 3
    Tytuł:
    Changes in plant water status, biochemical attributes and seed quality of black gram and green gram genotypes under drought
    Autorzy:
    Baroowa, B.
    Gogoi, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/11337.pdf
    Data publikacji:
    2015
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Opis:
    Drought is one of the major abiotic stresses which adversely affect crop growth and production worldwide as water is vital for every aspect of plant growth and development. The present experiment was carried out during the growing seasons (September – December) of 2012 and 2013 to evaluate the response of black gram (Vigna mungo L.) and green gram (Vigna radiata L.) in terms of some important growth indices, biochemical traits and seed quality under drought stress. Four commonly grown genotypes - T9, KU 301(black gram) and Pratap, SG 21-5 (green gram) of Assam, India were grown in a randomized block design with three replications under stress and non-stress conditions. Stress was applied by withholding irrigation for fifteen consecutive days at vegetative, flowering and pod filling stages. Leaf area index (LAI), seed protein content and protein yield significantly decreased (p ≤ 0.01) whereas proline, total flavonoids and anthocyanin content increased significantly (p ≤ 0.01) in response to water deficiency. Among the studied genotypes, T9 and Pratap showed better tolerance capacity towards the applied drought by presenting higher values of LAI, plant height stress tolerance index (PHSI), dry matter stress tolerance index (DMSI), proline, total flavonoids, anthocyanin, lower percentage of chlorophyll degradation and finally producing high quality seeds.
    Źródło:
    International Letters of Natural Sciences; 2015, 42
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Indices and their applicability under high temperature in potato (Solanum tuberosum L.) cultivars
    Autorzy:
    Paul, S.
    Gogoi, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/11453.pdf
    Data publikacji:
    2015
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Opis:
    The increasing temperature is going to be more vulnerable for cool season crops like potato which requires an optimum productivity temperature of 18 to 20 °C. Thus, breeding for heat tolerance has become very important. Therefore, some previously used indices for abiotic stress tolerance have been used in our study for screening of high temperature stress tolerance in potato. Three high yielding (Kufri jyoti, Kufri megha and Kufri pokraj) and two local (Rangpuria and Badami) commonly grown potato cultivars were selected for our experiment. Potato cultivars were sown under normal condition and two high temperature conditions (polyhouse and early season) and indices such as HSI (heat susceptibility index), HTI (heat tolerance index), GM (geometric mean) and HII (heat intensity index) were used to evaluate the performance of the cultivars under all the three temperature conditions. The positive and significant correlation between HTI (heat tolerance index), and GM (geometric mean) as well as with tuber yield under all the conditions revealed that these indices were efficient in selecting the high temperature tolerant potato cultivars. We recorded the equal applicability of these two indices for both high yielding and local group of potato cultivars. Our study revealed that cultivar Kufri megha and Rangpuria showed higher heat tolerance between high yielding and local cultivars respectively.
    Źródło:
    International Letters of Natural Sciences; 2015, 43
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
    Autorzy:
    Ghosh, S.
    Chetia, D.
    Gogoi, N.
    Rudrapal, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096418.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    1
    2
    4-trioxane
    Plasmodium falciparum
    drug resistance
    molecular docking
    molecular dynamics
    falcipain 2 inhibitors
    Opis:
    Despite significant progress made in drug discovery and development over the past few decades, malaria remains a life-threatening infectious disease across the globe. Because of the widespread emergence of drug-resistant strains of Plasmodium falciparum, the clinical utility of existing drug therapies including Artemisinin-based Combination Therapies (ACTs) in the treatment of malaria has been increasingly limited. It has become a serious health concern which, therefore, necessitates the development of novel drug molecules and/or alternative therapies to combat, particularly resistant P. falciparum. The objective of the present study was to develop 1,2,4-trioxane derivatives as novel antimalarial agents that would be effective against resistant P. falciparum. In our study, 15 new trioxane derivatives were designed by molecular modification of the 1,2,4-trioxane scaffold as possible antimalarial agents. Molecular modeling studies of trioxane derivatives were performed based on the CADD approach using Biovia Discovery Studio (DS) 2018 software. The protein-ligand docking study was performed against P. falciparum falcipain 2 (FP-2) using the simulation-based docking protocol LibDock by the flexible docking method. The assessment of drug-likeness, ADMET properties, and toxicity was also performed. Furthermore, the compounds CC3 and CC7, which showed the best binding affinity against the target P. falciparum FP-2, were investigated by molecular dynamics (MD) simulation studies followed by the calculation of MM-PBSA binding free energy of protein-ligand complexes using DS 2020. Results of the docking study showed that among the 15 compounds, three trioxane derivatives were found to possess promising binding affinity with LibDock scores ranging from 117.16 to 116.90. Drug-likeness, ADMET, and toxicity properties were found to be satisfactory for all the compounds. Among the 15 compounds, two compounds, namely CC3 and CC7, showed the highest binding affinity against FP-2 with LibDock score of 117.166 and 117.200, respectively. The Libdock score of the co-crystal inhibitor was 114.474. MD studies along with MM-PBSA calculations of binding energies further confirmed the antimalarial potential of the compounds CC3 and CC7, with the formation of well-defined and stable receptor-ligand interactions against the P. falciparum FP-2 enzyme. Additionally, the selectivity of trioxane hits identified as potential inhibitors of P. falciparum cysteine protease FP-2 was determined on human cysteine proteases such as cathepsins (Cat K and Cat L), which are host homologous. Finally, it was concluded that the newly designed 1,2,4-trioxane derivatives can be further studied for in vitro and in vivo antimalarial activities for their possible development as potent antimalarial agents effective against resistant P. falciparum
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 257-275
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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