- Tytuł:
-
Nukleozydo i oligonukleozydo boranofosfoniany : metody syntezy i wybrane właściwości biologiczne
Nucleoside and oligonucleoside boranephosphonates : synthetic methods and selected biological properties - Autorzy:
- Gołębiewska, Justyna
- Powiązania:
- https://bibliotekanauki.pl/articles/171646.pdf
- Data publikacji:
- 2020
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
nukleozydo boranofosfoniany
strategie syntetyczne
odporność na nukleazy
aktywność biologiczna
nucleoside boranephosphonate
synthetic strategies
nuclease resistance
biological activity - Opis:
- Interest in boron-containing compounds has grown in recent years due to their potential medicinal and biochemical applications. Nucleoside boranephosphonates are analogues of naturally occurring nucleoside phosphates in which one of the non- bridging oxygen atom has been replaced by a BH3 group [1]. This modification imparts unique biological properties to nucleotides and nucleic acids. DNA and RNA fragments containing boranephosphonate internucleotide linkages are resistant to various nucleases, stimulate the RNase H activity, and reveal high lipophilicity, which significantly enhances their cellular uptake [2]. The hydrolytic stability and nuclease resistance make these compounds attractive candidates in designing new therapeutics and medicinal diagnostics. Considering these characteristics nucleoside boranephosphonates constitute a promising class of nucleotide analogues worth exploring for biological purposes.
- Źródło:
-
Wiadomości Chemiczne; 2020, 74, 7-8; 477-506
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
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