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    Tytuł:
    Controlled drug delivery systems for improved efficacy and bioavailability of flavonoids
    Autorzy:
    Gopikrishna, A.
    Girigoswami, A.
    Girigoswami, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/24200649.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
    Tematy:
    flavonoids
    controlled drug delivery system
    pH-responsive
    electro-responsive
    NIR-responsive
    flawonoidy
    system kontrolowanego uwalniania leku
    Opis:
    Purpose In past decades, experiments have been done to find the properties of plant polyphenols and their protective role in various diseases. In the present study, a brief review has been done on flavonoids’ protective role in different diseases and controlled drug delivery systems that can be feasible for improving flavonoids’ bioavailability as well as their efficacy in the biological system. Design/methodology/approach Keywords searched in PubMed, and Google Scholar are “Flavones and cardiovascular diseases, flavones and neurodegenerative diseases, isoflavones and neurodegenerative diseases, Flavonoids and ageing, Flavonoids and diseases, total flavonoid content in vegetables, total flavonoid content in fruits, controlled drug delivery system and flavonoids” and the significant recent articles are selected for writing this review. Findings Flavonoids are active components present in plant products that have been found to exert several health benefits, especially in retarding the deleterious effects of CVD, cancer, ageing, diabetes, and neurodegenerative diseases. The different clinical studies have also supported the above notions, and in this commentary, we have highlighted some important findings in the field of flavonoid research. Even though it has various bioactive efficacy, most flavonoids have less bioavailability, requiring controlled drug delivery methods that can also improve flavonoids' bioavailability and stability. pH-, electro-, infrared radiation-, redox- responsive methods of controlled drug release systems are some of the valuable techniques for improving the rate of drug release and bioavailability at the targeted site. Research limitations/implications Research is warranted in this field for improving and developing various materials that can be utilized in the formation of scaffolds/polymers that improves drug loading and controlled drug release properties at the targeted site. Originality/value This review will help the readers to design new strategies in flavonoid research with the help of controlled drug release methods for increased bioavailability and rate of drug release/ controlled drug release.
    Źródło:
    Journal of Achievements in Materials and Manufacturing Engineering; 2023, 116, 2; 49--60
    1734-8412
    Pojawia się w:
    Journal of Achievements in Materials and Manufacturing Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanomedicine - a boon for respiratory disease management
    Autorzy:
    Balasubramanian, D.
    Lavanya, S.J.
    Girigoswami, A.
    Girigoswami, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/24200620.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
    Tematy:
    nanomedicine
    asthma
    chronic obstructive pulmonary disease
    cystic fibrosis
    respiratory diseases
    nanomedycyna
    astma
    przewlekła obturacyjna choroba płuc
    mukowiscydoza
    choroby układu oddechowego
    Opis:
    Purpose: Respiratory diseases affect the lungs and other parts of the respiratory system. The respiratory disease affects hundreds of millions of humans, and premature death is observed in nearly four million people yearly. The major cause of the increase in this disease is the increased level of air pollution and higher tobacco usage in public places. Design/methodology/approach: We have used the search engines PubMed and Google Scholar for the keywords Respiratory diseases, Nanomaterials, diagnosis, Nanomedicine, and Target drug delivery; recent and relevant articles are selected for reviewing this paper. Findings: Nanomedicine is a recent field of research that deals with monitoring, repairing, theragnosis, and development of human biological systems at the sub-atomic level, where we utilize engineered nanodevices and nanostructures. The conventional therapeutic strategies designed for respiratory diseases have limited solubility and bioavailability. Moreover, the robust effect of the drugs led to adverse side effects due to their high dose requirement. The local delivery of therapeutic Nanoparticles (NPs) or drug-loaded nano vehicles to the lung is a safe technique for managing various respiratory tract-related diseases like chronic obstructive pulmonary diseases, cystic fibrosis, lung cancer, tuberculosis, asthma, and infection. To overcome the difficulties of conventional treatment with antibiotics and anti-inflammatory drugs, nano-enabled drug delivery, nanoformulations of drugs as well as drug nanoencapsulation have been used recently. In this mini-review, we will discuss the importance and application of nanomedicine for diagnosis, treatment and clinical research involved in the different types of respiratory diseases. Practical implications: Nanomedicine provides an alternative delivery of drugs with the help of various nanocarriers, which enhances controlled drug delivery at the pulmonary region and can be used for treating and diagnosing respiratory diseases in vivo and in vitro studies. Further experiments followed by clinical examination are warranted to prove the potential application of nanomedicine in treating respiratory disease. Originality/value: This mini-review will help the readers and budding scientists apply new methods for developing highly efficient drugs with low side effects and improved targeted sites of action.
    Źródło:
    Archives of Materials Science and Engineering; 2023, 119, 2; 71--85
    1897-2764
    Pojawia się w:
    Archives of Materials Science and Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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