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Wyszukujesz frazę "Gawrychowski, Mariusz" wg kryterium: Autor


Wyświetlanie 1-9 z 9
Tytuł:
Oxidative stress in proliferative lesions of parathyroid gland
Autorzy:
Deska, Mariusz
Romuk, Ewa
Segiet, Oliwia
Polczyk, Joanna
Buła, Grzegorz
Gawrychowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1392364.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
oxidative stress
primary hyperparathyroidism
parathyroid hyperplasia
parathyroid adenoma
Opis:
Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-9 z 9

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