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Tytuł:
Internal Friction of Li7La3Zr2O12 Based Lithium Ionic Conductors
Autorzy:
Wang, X. P.
Song, L.
Hu, J.
Xia, Y. P.
Xia, Y.
Gao, Y. X.
Zhang, L. C.
Magalas, L. B.
Fang, Q. F.
Powiązania:
https://bibliotekanauki.pl/articles/958222.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
lithium ionic conductor
Li7La3Zr2O12
internal friction
Opis:
The diffusion mechanisms of lithium ions in tetragonal phase as well as in Al and Nb stabilized cubic Li7La3Zr2O12 compounds were investigated by low-frequency internal friction technique. In the cubic Li7La3Zr2O12 phase, a remarkable relaxation-type internal friction peak PC with a peak height up to 0.12 was observed in the temperature range from 15°C to 60°C. In the tetragonal phase however, the height of the PT peak dropped to 0.01. The obvious difference of the relaxation strength between the cubic and tetragonal phases is due to the different distribution of lithium ions in lattice, ordered in the tetragonal phase and disordered in the cubic phase. Based on the crystalline structure of the cubic garnet-type Li7La3Zr2O12 compound, it is suggested that the high internal friction peak in the cubic phase may be attributed to two diffusion processes of lithium ions: 96h↔96h and 96h↔24d.
Źródło:
Archives of Metallurgy and Materials; 2016, 61, 1; 21-24
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental and Numerical Simulation of the Tensile Behaviour of a Biaxial Warp-knitted Composite
Eksperymentalna i numeryczna symulacja rozciągania kompozytów wzmocnionych dwuosiową dzianiną osnowową
Autorzy:
Gao, X.
Yang, X.
Li, D.
Li, Y.
Powiązania:
https://bibliotekanauki.pl/articles/233474.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
Tematy:
biaxial warp-knitted composite
tensile behavior
finite element analysis
dwuosiowy kompozyt z osnową
zachowanie na rozciąganie
analiza elementów skończonych
Opis:
In this paper a composite reinforced with biaxial warp-knitted fabric and epoxy resin was manufactured by applying vacuum assisted resin transfer moldings (VARTM). The quasi-static tensile behaviour was experimentally tested in 0° and 90° directions, respectively. A finite element model of biaxial warp-knitted composites was developed on a meso-scale. The tensile behaviour of the composites was numerical simulated and compared with the experimental results. It showed that there is an approximate agreement between experimental and numerical results. There are maximum errors sum of squares of 14.52% and 33.29%. The finite element model of biaxial warp-knitted composites has higher accuracy, which can be used to study the static and dynamic mechanical properties.
Wykonano kompozyt wzmocniony dwuosiową dzianiną osnowową i żywicą epoksydową z zastosowaniem próżniowego przenoszenia żywicy (VARTM). Quasi-statyczne właściwości rozciągania badano doświadczalnie odpowiednio w kierunkach 0° i 90°. Opracowano model skończonych elementów dwuosiowych kompozytów z dzianinami. Dokonano symulacji numerycznej zachowania kompozytów podczas rozciągania, a następnie porównano wyniki teoretyczne z wynikami eksperymentalnymi. Wykazano, że istnieje przybliżona zgodność między wynikami eksperymentalnymi i liczbowymi. Stwierdzono, że błędy maksymalne błędy kształtują się na poziomie 14,52% i 33,29%. Zaprezentowany model elementów skończonych ma wysoką dokładność i można go wykorzystać do badania statycznych i dynamicznych właściwości mechanicznych kompozytów.
Źródło:
Fibres & Textiles in Eastern Europe; 2018, 6 (132); 71-76
1230-3666
2300-7354
Pojawia się w:
Fibres & Textiles in Eastern Europe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved linear complexities of the frequency hopping sequences in two optimal sets
Autorzy:
Gao, J.
Li, X.
Wei, Y.
Powiązania:
https://bibliotekanauki.pl/articles/206234.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
frequency hopping sequence
linear complexity
permutation polynominal
optimal set
Opis:
For the anti-jamming purpose, high linear complexity is desired for each frequency hopping sequence in an optimal set. Using a proper power permutation, Wang has shown that an optimal set of frequency hopping sequences with small linear complexity can be transformed into a new optimal set of frequency hopping sequences with large linear complexity. This paper conains two results. First, we extend the result of Wang. A power permutation is only suitable for a special construction of optimal set of frequency hopping sequences, see Wang (2011). However, the power permutation chosen in this paper applies to the general construction of optimal set of frequency hopping sequences. Second, by using a binomial permutation polynomial P(x), which is different from those permutations used before, we obtain a novel optimal set of frequency hopping sequences with high linear complexity from an optimal set of frequency hopping sequences with small linear complexity. By counting the number of different roots in the sequence representation, we determine the linear complexities of the frequency hopping sequences in two optimal sets transformed by the power permutation or binomial permutation.
Źródło:
Control and Cybernetics; 2012, 41, 2; 317-334
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ship trajectory tracking control system design based on sliding mode control algorithm
Autorzy:
Liu, Y.
Bu, R.
Gao, X.
Powiązania:
https://bibliotekanauki.pl/articles/259621.pdf
Data publikacji:
2018
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
LOS
ship trajectory
tracking control system
sliding mode control
Opis:
The paper reports the design and tests of the planar autopilot navigation system in the three-degree-of-freedom (3-DOF) plane (surge, sway and yaw) for a ship. The aim of the tests was to check the improved maneuverability of the ship in open waters using the improved nonlinear control algorithm, developed based on the sliding mode control theory for the ship-trajectory tracking problem of under-actuated ships with static constraints, actuator saturation, and parametric uncertainties. With the integration of the simple increment feedback control law, the dynamic control strategy was developed to fulfill the under-actuated tracking and stabilization objectives. In addition, the LOS (line of sight) guidance system was applied to control the motion path, whereas the sliding mode controller was used to emulate the rudder angle and propeller rotational speed control. Firstly, simulation tests were performed to verify the validity of the basic model and the tracking control algorithm. Subsequently, full scale maneuverability tests were done with a novel container ship, equipped with trajectory tracking control and sliding mode controller algorithm, to check the dynamic stability performance of the ship. The results of the theoretical and numerical simulation on a training ship verify the invariability and excellent robustness of the proposed controller, which: effectively eliminates system chattering, solves the problem of lateral drift of the ship, and maintains the following of the trajectory while simultaneously achieving global stability and robustness.
Źródło:
Polish Maritime Research; 2018, 3; 26-34
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of alpha and gamma radiolysis on Pu retention in the solvent TBP/kerosene
Autorzy:
Gao, Y
Zheng, W.
Cao, X.
Chen, S.
Powiązania:
https://bibliotekanauki.pl/articles/148296.pdf
Data publikacji:
2014
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
purex process
TBP solvent
alpha radiolysis
gamma radiolysis
Pu retention
Opis:
In light of the issue of radiolysis of the solvent system in PUREX process, alpha and gamma radiation stability of tributyl phosphate (TBP)/kerosene (OK) have been studied in this paper, in which 238Pu dissolved in the organic phase and 60Co are selected as alpha and gamma irradiation sources, respectively. The amount of the degradation products not easily removed after the washing process has been measured by the plutonium retention. The effects of the absorbed dose, the TBP volume fraction, the cumulative absorbed dose and the presence of UO2 2+ and Zr4+ on the radiolysis of the solvents have been investigated. The results have indicated that the Pu retention increases with the increase of the absorbed dose after alpha or gamma irradiation, and is larger for the solvent containing less TBP. There is competition between UO2 2+ and Pu4+ to complex with the degradation products, and Zr4+ accelerates the radiolysis of the system.
Źródło:
Nukleonika; 2014, 59, 4; 123-128
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hydrothermal Synthesis and Microstructural, Optical Properties Characterization of $YVO_4$ Phosphor Powder
Autorzy:
Zhang, S.
Liang, Y.
Gao, X.
Liu, H.
Powiązania:
https://bibliotekanauki.pl/articles/1207386.pdf
Data publikacji:
2014-01
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.55.-m
42.70.Hj
78.67.-n
Opis:
The phonon energy of $YVO_4$ crystal is lower than other usual compounds of salt. So it is suitable as host material for down-conversion materials. Hydrothermal method was adopted to synthesize $YVO_4$ phosphor powder with the use of yttrium oxide and sodium vanadate as raw material. The change in the relative integral intensity of the (200) and (112) diffraction peaks indicates that macroscopic stress in the lattice obviously changes with the elevated hydrothermal reaction temperature. The $YVO_4$ phosphor powder synthesized involves a certain agglomeration of small particles. The phonon vibration in the $YVO_4$ originates mainly from the internal vibrations in the vanadium-oxygen tetrahedron, in addition to the Y-O and O-H vibrations. Due to a low phonon energy of only $2.8188 × 10^{-21} J$, $YVO_4$ helps to improve the down-conversion efficiency of rare-earth ions. A bandgap value of approximately 3.8 eV for the synthesized $YVO_4$ powders leads to good absorption properties in the ultraviolet region. Upon excitation by the 320 nm ultraviolet photon, the intrinsic emission of $YVO_4$ powders is annihilated, and a broadband emission of $VO_4^{3-}$ near 450 nm is observed at room temperature. The $YVO_4$ phosphor powder synthesized at 180C exhibits the maximum photoluminescence intensity because of its excellent crystallization.
Źródło:
Acta Physica Polonica A; 2014, 125, 1; 105-110
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Focusing of linearly polarized helico-conical Lorentz beam with sine-azimuthal variation wavefront
Autorzy:
Bao, Y.
Lan, J.
Miao, Y.
Zhang, D.
Gao, X.
Powiązania:
https://bibliotekanauki.pl/articles/174305.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Lorentz beam
focusing properties
optical vortex
Opis:
In this article a theoretical research is described into focusing of a linearly polarized helico-conical Lorentz beam with a sine-azimuthal variation wavefront. The simulation results show the vortex charge on the axis, which has an obvious modulation effect on the focal modes of the Lorenz beam under certain beam parameters and phase parameters. Both the phase parameter and the vortex charge are zero, the focal spot appears round. The focal spot is symmetric about y axis when the charge is 0 and the phase parameter is adjusted. And the focal evolution patterns vary remarkably under different beam parameters and the phase parameters. In the process of focus evolution, there appears some novel focal patterns, such as a circle, a “T”, a butterfly, a small running humanoid, a whale tail, a flower of four leaves, a serpentine, a goldfish, a Chinese knot and an octopus, which indicates that the focus mode of the optical vortex Lorentz beam can be altered by changing the phase parameters and vortex charge.
Źródło:
Optica Applicata; 2018, 48, 3; 373-387
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on relationship between carbon dioxide emissions, imports, exports, and population in China
Autorzy:
Jin, Q.-Y.
Zhang, J.
Gao, Y.-Q.
Su, X.
Fu, Y.-S.
Powiązania:
https://bibliotekanauki.pl/articles/207318.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
population statistics
carbon dioxide
global warming
carbon dioxide emissions
total carbon
statystyki ludności
dwutlenek węgla
globalne ocieplenie
emisja dwutlenku węgla
węgiel całkowity
Opis:
Empirical relationships between carbon dioxide emission, imports, exports, and population have been investigated. An empirical model with carbon dioxide emissions, structure and scale of import and exports, populations was built Using ridge regression analysis and observed data from 1985 to 2006 in China, we examined the relationship between each part of carbon dioxide emission and corresponding coefficients, including GIV (gross imports value), GXV (gross exports value), and P (populations). The results have shown that the increasing trend in TCOE (total carbon dioxide emissions) was determined by the exports, while its standard level is determined by population. Increasing the imports may reduce TCOE. Considering working to expand economy, the best ways for China to reduce TCOE are to introduce advanced technology and take actions to guarantee strict execution of cut-emission policy. Although the increasing imports also can reduce TCOE, it is not reasonable for the global cut-emission policy. To control population is not applicable as the immense population base, so government's publicity for low-carbon live is a necessary and feasible way to reduce carbon dioxide emission.
Źródło:
Environment Protection Engineering; 2014, 40, 2; 75-85
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on the statistical characteristics of crosstalk in naval ships wiring harness based on Polynomial Chaos Expansion method
Autorzy:
Chi, Y.
Li, B.
Yang, X.
Wang, T.
Yang, K.
Gao, Y.
Powiązania:
https://bibliotekanauki.pl/articles/260090.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
naval ships wiring harness
crosstalk
Polynomial Chaos Expansion
statistical characteristics
Opis:
Crosstalk in wiring harness has been studied extensively for its importance in the naval ships electromagnetic compatibility field. An effective and high-efficiency method is proposed in this paper for analyzing Statistical Characteristics of crosstalk in wiring harness with random variation of position based on Polynomial Chaos Expansion (PCE). A typical 14-cable wiring harness was simulated as the object of research. Distance among interfering cable, affected cable and GND is synthesized and analyzed in both frequency domain and time domain. The model of naval ships wiring harness distribution parameter was established by utilizing Legendre orthogonal polynomials as basis functions along with prediction model of statistical characters. Detailed mean value, mean square error, probability density function and reasonable varying range of crosstalk in naval ships wiring harness are described in both time domain and frequency domain. Numerical experiment proves that the method proposed in this paper, not only has good consistency with the MC method can be applied in the naval ships EMC research field to provide theoretical support for guaranteeing safety, but also has better time-efficiency than the MC method. Therefore, the Polynomial Chaos Expansion method.
Źródło:
Polish Maritime Research; 2017, S 2; 205-214
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between flotation and Fe/Mn ratio of wolframite with benzohydroxamic acid and sodium oleate as collectors
Autorzy:
Yang, S.
Feng, Q.
Qiu, X.
Gao, Y.
Xie, Z.
Powiązania:
https://bibliotekanauki.pl/articles/109666.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
wolframite
flotation
collector mixture
benzohydroxamic acid
sodium oleate
Opis:
Several studies revealed that flotation of wolframite changes with different Fe/Mn ratios, but they did not reach a consensus. This relationship in the presence of benzohydroxamic acid (BHA) and sodium oleate (NaOl) as collectors was studied in this paper through comparison of probability distribution curve of wolframite with different Fe/Mn ratios between the raw ore and the flotation concentrate, the pure mineral flotation and solution chemistry of flotation. The results showed that wolframite with high Fe/Mn ratio showed higher flotation with BHA as a collector while the flotation behavior of wolframite was completely opposite with NaOl as a collector. Besides, the calculations of chemical equilibrium in the solution were plotted as ΔG°-pH graphs. The results revealed that the flotation of wolframite may be determined by the interaction between BHA and ferric(II) ion or between NaOl and manganous ion. From the perspective of collector mixture, the results also explain the high collecting capability of the BHA/NaOl collector mixture, which can be defined as “functional complementation”.
Źródło:
Physicochemical Problems of Mineral Processing; 2014, 50, 2; 747-758
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Removal of quinoline from aqueous solutions by lignite, coking coal and anthracite. Adsorption isotherms and thermodynamics
Autorzy:
Xu, H.
Huagn, G.
Li, X.
Gao, L.
Wang, Y.
Powiązania:
https://bibliotekanauki.pl/articles/110016.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
quinoline adsorption
coking coal
adsorption isotherms
thermodynamics
Opis:
Based on the concept of circular economy, a novel method of industrial organic wastewater treatment by using adsorption on coal is introduced. Coal is used to adsorb organic pollutants from coking wastewaters. After adsorption, the coal would be used for its original purpose, its value is not reduced and the pollutant is thus recycled. Through systemic circulation of coking wastewater zero emissions can be achieved. Lignite, coking coal and anthracite were used as adsorbents in batch experiments. The quinoline removal efficiency of coal adsorption was investigated. The coking coal and anthracite exhibited properties well-suited for adsorption onto both adsorbents. The experimental data were fitted to Langmuir and Freundlich isotherms as well as Temkin, Redlich–Peterson (R-P) and Dubinin-Radushkevich (D-R) models. Both Freundlich Isotherm and D-R model provided reasonable models of the adsorption process. The thermodynamic parameters of quinoline adsorption on coking coal were calculated. The thermodynamic parameters indicated that the adsorption process is exothermic and is a physical adsorption. The △S° value indicated that the adsorption entropy decreased because the adsorbate molecule was under restrictions after it adsorption on the coal surface. The coal adsorption method for removing refractory organic pollutants is a great hope for achieving zero emission waste water for a coking plant.
Źródło:
Physicochemical Problems of Mineral Processing; 2016, 52, 1; 214-227
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pretreatment of coking wastewater by an adsorption process using fine coking coal
Autorzy:
Gao, L.
Li, S.
Wang, Y.
Gui, X.
Xu, H.
Powiązania:
https://bibliotekanauki.pl/articles/110417.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
coking coal
coking wastewater
adsorption
COD
phenol
Opis:
A new technique for pretreatment of coking wastewater is introduced based on the concept of circular economy. Coal is fed into a coking system after adsorption. This study validates the feasibility of using coking coal to adsorb organic pollutants in coking wastewater. The sorption kinetics and equilibrium sorption isotherms of coking coal for removal of chemical oxygen demand (COD) and phenol from coking wastewater was also discussed in this paper. Gas chromatograph/mass spectroscopy (GC/MS) was used to detect changes in the quality of coking wastewater. The results showed that when coking coal dosage was 120 g/dm3, 65% of COD and 34% of phenol in waste water can be removed after 40 min of agitation. The surface functional groups of coking coal before and after adsorption were observed with a Fourier transform infrared spectrometer. The kinetics of COD and phenol adsorption from coking wastewater by coking coal fitted the pseudo second-order model. The adsorption process of coking coal can be classified into two categories, namely, rapid and slow. The Freundlich isotherm provided a better fit with all adsorption isotherms than the Langmuir isotherm. Coking coal could be a suitable low-cost adsorbent for recalcitrant organic pollutants.
Źródło:
Physicochemical Problems of Mineral Processing; 2016, 52, 1; 422-436
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A method for probing the refractive index change in photorefractive crystals
Autorzy:
Fu, M.
Gao, C.
Wang, X.
Cui, Y.
Dai, S
Powiązania:
https://bibliotekanauki.pl/articles/174913.pdf
Data publikacji:
2013
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Fourier transform profilometry
refractive index change
photorefractive effect
Opis:
A method for probing refractive index changes in photorefractive crystals using an interferometric technique and digital image processing was proposed. Based on equal thickness interference in LiNbO3 crystal and Fourier transform profilometry, we obtained phase value changes in interferograms induced by a photorefractive effect, and further calculated refractive index changes. The maximal values for extraordinary light (e-light) and ordinary light (o-light) are 6.6×10–4 and 1.2×10–4, respectively.
Źródło:
Optica Applicata; 2013, 43, 4; 731-737
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Visual Detection Method of Longitudinal Crack Based on Computer Image Processing During Slab Continuous Casting
Autorzy:
Liu, Y.
Wang, X.
Sun, Y.
Du, F.
Gao, Y.
Wang, F.
Wang, J.
Powiązania:
https://bibliotekanauki.pl/articles/351636.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
longitudinal crack
visual detection
image processing
continuous casting
Opis:
Based on the mould temperature measured by thermocouples during slab continuous casting, a difference of temperature thermograph is developed to detect slab cracks. In order to detect abnormal temperature region caused by longitudinal crack, the suspicious regions are extracted and divided by virtue of computer image processing algorithms, such as threshold segmentation, connected region judgement and boundary tracing. The abnormal regions are then determined and labeled with the eight connected component labeling algorithm. The boundary of abnormal region is also extracted to depict characteristics of longitudinal crack. Based on above researches, longitudinal crack with abnormal temperature region can be detected and is different from other abnormalities. Four samples of temperature drop are picked up to compare with longitudinal crack on the abnormal region formation, length, width, shape, et al. The results show that the abnormal region caused by longitudinal crack has a linear and vertical shape. The height of abnormal region is more than the width obviously. The ratio of height to width is usually larger than that of other temperature drop regions. This method provides a visual and easy way to detect longitudinal crack and other abnormities. Meanwhile it has a positive meaning to the intelligent and visual mould monitoring system of continuous casting.
Źródło:
Archives of Metallurgy and Materials; 2018, 63, 2; 673-680
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways
Autorzy:
Chen, Q.
Wang, X.X.
Jiang, S.W.
Gao, X.T.
Huang, S.Y.
Liang, Y.
Jia, H.
Zhu, H.F.
Powiązania:
https://bibliotekanauki.pl/articles/16647496.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
African swine fever virus
MGF360-12L
type I IFN
NF-κB
JAK/STAT
Opis:
African swine fever virus (ASFV) causes feverous and hemorrhagic disease of domestic pigs and European wild boars with high mortality, yet no commercial vaccine is currently available. Several ASFV strains with natural deletion or gene-targeted knockout of multiple MGF360 and MGF505 genes are attenuated in vitro and in vivo, and can offer full protection against homologous challenge. However, the mechanisms underlying the protection are not fully understood. This study aims to investigate the effects of MGF360-12L of ASFV-SY18 on the cGAS-STING signaling pathway and explore the potential mechanisms. We identified that ASFV-SY18 MGF360-12L could inhibit cGAS-STING, TBK1, or IRF3-5D-stimulated IFN-β expression and ISRE activation. Specifically, MGF360-12L inhibits both the activation of PRD(III-I) in a dose-dependent manner, and suppresses the exogenous expression of TBK1 and IRF3-5D. MGF360-12L could block NF-κB activation induced by overexpression of cGAS-STING, TBK1, IKKβ. Downstream of the IFN-β signaling, MGF360-12L blocks the ISRE promoter activation by reducing total protein level of IRF9. Moreover, MGF360-12L protein can inhibit IFN-β-mediated antiviral effects. In conclusion, our findings suggest that MGF360-12L is a multifunctional immune-evasion protein that inhibits both the expression and effect of IFN-β, which could partially explain the attenuation of relevant gene-deleted ASFV strains, and shed light on the development of efficient ASFV live attenuated vaccines in the future.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 119-130
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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