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Wyświetlanie 1-15 z 24
Tytuł:
Influence of food-derived advanced glycation end products on health
Autorzy:
Galiniak, Sabina
Bieiadecki, Marek
Powiązania:
https://bibliotekanauki.pl/articles/454957.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
advanced glycation end products AGEs
CML
diabetes
glycation
Opis:
Introduction. Advanced glycation end products (AGEs) are compounds formed endogenously in the human body. Besides this source of AGEs, they also exist in food and can be generated during cooking. Enhanced endogenous generation and intake of dietary AGEs have physiological impact on human health and are associated with progression of many diseases, including diabetes and its complications. Aim. The purpose of this review is to the present the current state of knowledge about the various negative effects of advanced glycation end products on human health. Materials and methods. This study is based on analysis of literature reporting the content of AGEs in food and high or low AGEs dietary interventions in human and animal subjects. Results. Literature data present databases gathering description of AGEs determinations in various types of food. Conclusions. Excessive consumption of AGEs-rich products, especially abundant in protein and fat or cooked for a long time at high temperature, may contribute to the deterioration of human health, including development of hypertension, insulin resistance, and diabetic complications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 330-334
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modification of the deoxyribose test to detect strong iron binding
Autorzy:
Sadowska-Bartosz, Izabela
Galiniak, Sabina
Bartosz, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1038707.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chelation
deoxyribose test
desferrioxamine
DETAPA
EDTA
Fenton reaction
hydrogen peroxide
hydroxyl radical
iron
superoxide
Opis:
Deoxyribose test has been widely used for determination of reactivities of various compounds for the hydroxyl radical. The test is based on the formation of hydroxyl radical by Fe2+ complex in the Fenton reaction. We propose a modification of the deoxyribose test to detect strong iron binding, inhibiting participation of Fe2+ in the Fenton reaction, on the basis of examination of concentration dependence of deoxyribose degradation on Fe2+ concentration, at a constant concentration of a chelating agent.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 195-198
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reakcja Fentona
Fenton reaction
Autorzy:
Sadowska-Bartosz, Izabela
Galiniak, Sabina
Bartosz, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1191756.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Toksyczność żelaza jest uwarunkowana reakcją Fentona czyli tworzeniem rodników hydroksylowych w reakcji z nadtlenkiem wodoru. Artykuł przedstawia skrótowo historię odkrycia Fentona, kontrowersję dotyczącą natury reaktywnego oksydanta tworzonego w reakcji Fentona, reaktywność rodnika hydroksylowego, udział jonów innych metali w reakcji Fentona i wykorzystanie reakcji Fentona do oczyszczania ścieków.
The toxicity of iron is mainly due to the Fenton reaction i. e. formation of hydroxyl radicals in a reaction with hydrogen peroxide. The paper presents briefly the history of Fenton discovery, the controversy regarding the nature of the reactive oxidant formed in the Fenton reaction, the reactivity of the hydroxyl radical, participation of other metal ions in the Fenton reaction and the application of the Fenton reaction for wastewater treatment.
Źródło:
Kosmos; 2014, 63, 3; 309-314
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
Autorzy:
Biesiadecki, Marek
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454725.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
asthma
nitric oxide
ROC curve
Opis:
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 253-258
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glycosaminoglycan concentration in cancer tissue
Autorzy:
Bar, Piotr
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Filip, Rafał
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454799.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
fixed charge density glycosaminoglyca
magnetic resonance imaging
Opis:
Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 175-178
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infliximab in therapy of inflammatory bowels diseases
Autorzy:
Bar, Piotr
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Filip, Rafał
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454884.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
infliximab
TNFα
ulcerative colitis
Opis:
Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 79-82
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibromuscular dysplasia – a case description
Autorzy:
Leksa, Natalia
Seweryn, Bartosz
Uberman-Kluz, Dominika
Galiniak, Sabina
Kawalec, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/454927.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
fibromuscular dysplasia
arteries
computed tomography
Opis:
Introduction. Fibromuscular dysplasia is an idiopathic, non-inflammatory and non-atherosclerotic disease that affects the walls of arteries (mostly renal and carotid arteries). Histological classification distinguishes three main types of the disease, depending on the structural changes occurring in one of the three layers of arterial vessel walls. Objective. We present here a case of fibromuscular dysplasia affecting the internal carotid arteries. Case description. This article describes the case of a 52-year-old female patient with hypertension, hyperlipidemia, and a cardiac pacemaker in whom computed tomography angiography revealed a narrowing of the internal carotid arteries without atherosclerotic symptoms. We describe the diagnostic methods and various types of treatment that the patient suffering from fibromuscular dysplasia was subjected to. Conclusions. Due to a low detection rate of fibromuscular dysplasia, if the disease is suspected, all available diagnostic methods should be employed. Taking into account the unknown etiology of the disease, it is not possible to use a preventive therapy, or a therapy focused on stalling the progression of the disease
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 63-67
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma
Autorzy:
Osuchowski, Michał
Aebisher, David
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454672.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Prostate cancer
multiparametric MRI (mpMRI) biparametric MRI (bpMRI)
staging
Opis:
Introduction. The role of multiparametric magnetic resonance imaging (mpMRI) in staging prostate carcinoma has been increasing over the last years. It’s high sensitivity is indispensable when diagnosing this disease. It is a very accurate imaging method that helps the physician choose the best treatment method for his patient. Aim. Assessment of mpMRI which uses both anatomic and functional imaging techniques as a method to diagnose prostatic lesions. Advantages and disadvantages of staging prostate carcinoma with the use of biparametric MRI (bpMRI). Methods. The literature search was performed. Results. MpMRI can be used in pre-operative staging of prostate cancer. The technique is accurate in diagnosing and assessment of prostate carcinoma with Gleason Score (GS) of 7 and above. It is also recommended when planning a second biopsy of the prostatic gland.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 4; 331-333
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging studies of kidney cancer
Autorzy:
Przyczyna, Piotr
Aebisher, David
Gustalik, Joanna
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1597349.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Kidney cancer
MRI
PET
Opis:
In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 4; 334-337
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of imaging tests to obtain optimal margins in breast surgery
Autorzy:
Ostańska, Elżbieta
Bartusik-Aebisher, Dorota
Gustalik, Joanna
Aebisher, David
Galiniak, Sabina
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1597322.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast conserving surgery
ductal carcinoma in situ
extensive itraductal component invasive breast cancer
lobular carcinoma in situ
Opis:
Introduction. The proper negative margins (R0) breadth in the breast - conserving surgery for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) is very important. The presence positive surgical margins (R1) is associated with the necessity of reoperation. It delays the adjuvant therapy and psychologically burdens the patient. The re-operation increases the costs of treatment. The introduction of mammography (MMG) increased detection of DCIS by 20%. With the increase in malignancy, cancer detection decreases in MMG, inversely in MRI groving. Effective preoperative and intraoperative diagnosis aims to reduce the number of R1 resections. Aim. The size of the tumor next to its biology, determines the clinical course of the tumor. The accurate analysis of imaging tests is important. Material and methods. This analysis was performed using a systematic literature search. Results. Adequate surgical margins in breast cancer surgery for breast cancer have been reviewed. It is important to know if the cancer is multifocal and what the extent of the tumor is. Conclusion. The adequacy of margins is important for adjusting the volume of excision. It is avoiding unnecessary resection of healthy breast tissue. It is essential for a good cosmetic result and the local recurrence rate. The combination of breast MRI with conventional breast imaging resulted in the lover rate of the R1 resectios and the lower rate of the re-operation.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 246-249
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rapidly progressing dementia as a manifestation of the Creutzfeldt-Jakob disease: an analysis of two cases
Autorzy:
Bartosz, Seweryn
Leksa, Natalia
Uberman-Kluz, Dominika
Szymczak, Artur
Biesiadecki, Marek
Galiniak, Sabina
Powiązania:
https://bibliotekanauki.pl/articles/454939.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
14-3-3 protein
brain biopsy
cerebrospinal fluid
Creutzfeldt-Jakob disease
EEG
prion
Opis:
Introduction. Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of the central nervous system which is caused by an infectious protein called prion. Multiple forms of CJD have been classified including sporadic (more than 90% cases), familial, iatrogenic and variant type of disease. CJD, especially in its early stages, is a highly challenging illness to diagnose. Aim. Article aims to present cases of Creutzfeldt-Jackob disease with early symptoms of rapidly progressing dementia at the initial stage of CJD. Description of the cases. This paper describes two cases of patients with suspected CJD with a history of rapidly progressive dementia admitted to the Department of Neurology, MSWiA Hospital in Rzeszów. Conclusion. Despite the fact that CJD is an incurable illness and there is no cure guaranteeing recovery, it is important to make the right diagnosis. Assay of 14-3-3 protein in cerebrospinal fluid is a sensitive and specific marker which is helpful in the diagnosis of CJD. The only relevant method of correctly confirming a diagnosis of this disease is by performing a brain biopsy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 89-93
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical aspects of protein glycation
Autorzy:
Galiniak, Sabina
Krawczyk-Marć, Izabela
Sęk-Mastej, Anna
Leksa, Natalia
Biesiadecki, Marek
Orkisz, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/454911.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
AGEs
glycation
advanced glycation end products
multiple sclerosis
Opis:
Introduction. Glycation is a post-translational modification of proteins that depends on the non-enzymatic linkage of a ketone or aldehyde group of sugar with a free amino group of protein. Pathological effects of this process are observed in many disease states under conditions of hyperglycemia, in diabetic complications, and neurodegenerative diseases such as multiple sclerosis. Aim. In this paper we present the characteristics of the glycation process, its consequences, as well as a review of current knowledge about the role of glycation in multiple sclerosis. Material and methods. The databases EBSCO, PubMed, ScienceDirect and SpringerLink were used to search the literature. Analysis of the literature. Intermediate glycation products form a number of derivatives that contribute to oxidative stress and structural changes in the proteins, including induction of aggregation or reduction of affinity for drug proteins. Glucose products may contribute to neurodegenerative changes in patients with multiple sclerosis. Determination of protein glycation products can be successfully used to evaluate the course of multiple sclerosis as a diagnostic marker.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 3; 263-267
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of alcohol on neuroglia in the developing brain and in adults
Autorzy:
Krawczyk-Marć, Izabela
Galiniak, Sabina
Sęk-Mastej, Anna
Marć, Mateusz
Orkisz, Stanisław
Wawrzyniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/454917.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
brain
alcohol
neuroglia
Opis:
Introduction. During puberty, the young body undergoes transformation not only within the reproductive and hormonal systems, but also significant changes in the central nervous system (CNS). Matured neural connections improve the integration of distant brain regions, the plasticity of neurons increases, and thus specialization of the brain occurs in the performance of specific tasks. During these transformations, both neurons and the accompanying neuroglia are sensitive to all toxic factors, among which ethanol occupies a special place. It causes an increase in the activity of glial cells, which by directing pro-inflammatory cytokines directly contribute to the death of apoptotic neurons. A long-lasting and irreversible impairment of brain function, especially in the hippocampus occurs as a result of alcohol abuse during the period of development. Aim. This paper presents an overview of current knowledge about the effects of alcohol on neuroglia in the developing brain and in adults. Materials and methods. The literature review of the following databases has been conducted: EBSCO, PubMed, Science Direct, Springer Link. Conclusions. The results of alcohol research have shown that it affects the neurotransmission and fluidity of cell membranes, changing the activity of neurons. By binding to GABA receptor (GABA) and N-methyl-D-aspartate receptors (NMDA receptor for glutamate), ethanol suppresses brain function. In addition to increased sensitivity and susceptibility to the addictive effects of ethanol, the neurogeneration activity is intensified followed by the induction and release of pro-inflammatory cytokines, which in the first stage disrupt the cortical function hindering logical thinking and disrupting the limbic system, directly affecting the memory and learning processes. Next, the cerebellum is attacked, which results in the impairment of balance and motor coordination, and consequently acts on the brain stem, directly affecting the respiratory and circulatory control centers.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 335-340
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adrenomyeloneuropathy – a case report
Autorzy:
Leksa, Natalia
Aebisher, David
Galiniak, Sabina
Uberman-Kluz, Dominika
Bartosz, Serweryn
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454995.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adrenoleukodystrophy
fatty acids
steroid therapy
Opis:
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
Autorzy:
Pogoda, Katarzyna
Pucka, Maria
Tabarkiewicz, Jacek
Bober, Zuzanna
Aebisher, David
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454731.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cell cultures
lung cancer
lycopene
kidney cancer
magnetic resonance imaging relaxation times
Opis:
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 24

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