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Wyszukujesz frazę "Gackowski, Daniel" wg kryterium: Autor

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    Wyświetlanie 1-6 z 6
    Tytuł:
    Cellular level of 8-oxo-2-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base/nucleoside.
    Autorzy:
    Foksinski, Marek
    Gackowski, Daniel
    Rozalski, Rafał
    Olinski, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1043637.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    8-oxoguanine
    oxidative DNA damage
    8-oxo-2'-deoxyguanosine
    Opis:
    We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are discussed.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 549-553
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Background level of 8-oxo-2-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.
    Autorzy:
    Gackowski, Daniel
    Ciecierski, Marek
    Jawień, Arkadiusz
    Oliński, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1044149.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    α-tocopherol
    ascorbic acid
    retinol
    8-oxo-2'-deoxyguanosine
    Opis:
    Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 2; 535-539
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lymphocyte labile iron pool, plasma iron, transferrin saturation and ferritin levels in colon cancer patients.
    Autorzy:
    Gackowski, Daniel
    Kruszewski, Marcin
    Banaszkiewicz, Zbigniew
    Jawien, Arkadiusz
    Olinski, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1043840.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    labile iron pool
    iron metabolism
    colon cancer
    Opis:
    Patients with colorectal carcinoma showed statistically significant lower values of transferrin saturation, total iron binding capacity and serum iron level as compared with control group, while the level of ferritin and the size of labile iron pool in carcinoma patients were higher, although this difference was not statistically significant. Our observations are in favour of the hypothesis which suggests that changes in iron metabolism restrict iron availability for tumour cells and as consequence, slow their growth.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 269-273
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oxidative damage to DNA and antioxidant status in aging and age-related diseases
    Autorzy:
    Olinski, Ryszard
    Siomek, Agnieszka
    Rozalski, Rafal
    Gackowski, Daniel
    Foksinski, Marek
    Guz, Jolanta
    Dziaman, Tomasz
    Szpila, Anna
    Tudek, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1041102.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ROS
    aging
    oxidative DNA damage
    age-related diseases
    BER
    GO system
    Opis:
    Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 11-26
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cu,Zn-superoxide dismutase deficiency in mice leads to organ-specific increase in oxidatively damaged DNA and NF-κB1 protein activity
    Autorzy:
    Siomek, Agnieszka
    Brzoska, Kamil
    Sochanowicz, Barbara
    Gackowski, Daniel
    Rozalski, Rafal
    Foksinski, Marek
    Zarakowska, Ewelina
    Szpila, Anna
    Guz, Jolanta
    Bartlomiejczyk, Teresa
    Kalinowski, Bartlomiej
    Kruszewski, Marcin
    Olinski, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1042730.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Cu,Zn-SOD deficiency
    NF-κB pathway
    oxidative stress
    Opis:
    Earlier experimental studies have demonstrated that: i) Cu,Zn-superoxide dismutase deficiency leads to oxidative stress and carcinogenesis; ii) dysregulation of NF-κB pathway can mediate a wide variety of diseases, including cancer. Therefore, we decided, for the first time, to examine the level of oxidative DNA damage and the DNA binding activity of NF-κB proteins in SOD1 knockout, heterozygous and wild-type mice. Two kinds of biomarkers of oxidatively damaged DNA: urinary excretion of 8-oxodG and 8-oxoGua, and the level of oxidatively damaged DNA were analysed using HPLC-GC-MS and HPLC-EC. The DNA binding activity of p50 and p65 proteins in a nuclear extracts was assessed using NF-κB p50/p65 EZ-TFA transcription factor assay. These parameters were determined in the brain, liver, kidney and urine of SOD1 knockout, heterozygous and wild-type mice. The level of 8-oxodG in DNA was higher in the liver and kidney of knockout mice than in wild type. No differences were found in urinary excretion of 8-oxoGua and 8-oxodG between wild type and the SOD1-deficient animals. The activity of the p50 protein was higher in the kidneys, but surprisingly not in the livers of SOD1-deficient mice, whereas p65 activity did not show any variability. Our results indicate that in Cu,Zn-SOD-deficient animals the level of oxidative DNA damage and NF-κB1 activity are elevated in certain organs only, which may provide some explanation for organ-specific ROS-induced carcinogenesis.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 577-583
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dynamics of estrogen-induced oxidative stress
    Autorzy:
    Kobiela, Jarek
    Stefaniak, Tomasz
    Krajewski, Jacek
    Kalinska-Blach, Beata
    Zurawa-Janicka, Dorota
    Lachinski, Andrzej
    Gackowski, Daniel
    Olinski, Ryszard
    Nowak, Jerzy
    Knap, narcyz
    Lipinska, Barbara
    Sledzinski, Zbigniew
    Wozniak, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/1041076.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    8-oxodGuo
    estradiol
    protein oxidation
    carcinogenesis
    DNA damage
    lipid peroxidation
    Opis:
    The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 289-295
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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