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Wyszukujesz frazę "Gabig, Magdalena" wg kryterium: Autor

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    Wyświetlanie 1-6 z 6
    Tytuł:
    An introduction to DNA chips: principles, technology, applications and analysis.
    Autorzy:
    Gabig, Magdalena
    Węgrzyn, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044090.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    gene expression
    DNA array
    oligonucleotide array
    hybridisation
    Opis:
    This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene's expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 3; 615-622
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Escherichia coli RNA polymerase α subunit and transcriptional activation by bacteriophage λ CII protein
    Autorzy:
    Gabig, Magdalena
    Obuchowski, Michał
    Ciesielska, Agnieszka
    Latała, Barbara
    Węgrzyn2, Alicja
    Thomas, Mark
    Węgrzyn, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044881.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1998, 45, 1; 271-280
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Simultaneous siRNA-mediated silencing of pairs of genes coding for enzymes involved in glycosaminoglycan synthesis
    Autorzy:
    Dziedzic, Dariusz
    Narajczyk, Magdalena
    Gabig-Cimińska, Magdalena
    Jakóbkiewicz-Banecka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039752.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    GAGs
    MPSs
    Opis:
    It has been demonstrated recently that it is possible to decrease expression of genes coding for enzymes involved in synthesis of glycosaminoglycans (GAGs) by using specific siRNAs which interfere with stability of particular mRNAs. This procedure has been proposed as a potential treatment for patients suffering from mucopolysaccharidoses, a group of inherited metabolic diseases caused by dysfunction of enzymes required for GAG degradation, and resultant storage of these compounds in cells of affected persons. Here, we asked if the simultaneous use two species of specific siRNAs aimed at silencing two genes involved in particular steps of GAG synthesis may be more effective than the use of single siRNA. We found that inhibition of GAG synthesis in cells treated with two siRNAs is generally more effective than using single siRNAs. However, the differences were not statistically significant, therefore the potential benefit from the use of two siRNAs over the use of a single siRNA is doubtful in the light of the cost-benefit ratio and possibly stronger side-effects of the putative therapy.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 293-298
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies
    Autorzy:
    Chmielarz, Izabela
    Gabig-Cimińska, Magdalena
    Malinowska, Marcelina
    Banecka-Majkutewicz, Zyta
    Węgrzyn, Alicja
    Jakobkiewicz-Banecka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039693.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ERT
    MPS
    SRT
    siRNA
    Opis:
    Cytotoxicity of laronidase (Aldurazyme®), employed in enzyme replacement therapy (ERT) for mucopolysaccharidosis type I (MPS I) and various siRNAs, tested previously in studies on substrate reduction therapy (SRT) for mucopolysaccharidoses, was tested. The enzyme did not cause any cytotoxic effects, and the siRNAs did not inhibit growth of most investigated cell lines. However, some cytotoxic effects of some tested siRNAs were observed in one MPS IIIA cell line. The efficacy of a combination of enzyme replacement therapy and siRNA-based substrate deprivation therapy was tested on three MPS I cell lines. Surprisingly, different results were obtained for different cell lines. The decrease of glycosaminoglycan storage in cells treated simultaneously with both methods was: (i) less pronounced than obtained with either of those methods used alone in one cell line, (ii) similar to that observed for enzyme replacement therapy in another cell line, and (iii) stronger than that obtained with either of the methods used alone in the third cell line. Therefore, it appears that the effects of various therapeutic methods may strongly depend on the features of the MPS cell line.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 697-702
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular factors involved in the development of diabetic foot syndrome
    Autorzy:
    Bruhn-Olszewska, Bożena
    Korzon-Burakowska, Anna
    Gabig-Cimińska, Magdalena
    Olszewski, Paweł
    Węgrzyn, Alicja
    Jakóbkiewicz-Banecka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039639.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Diabetic foot syndrome
    molecular mechanisms
    Charcot neuroartropathy
    bone metabolism
    Opis:
    Diabetes is one of the major challenges of modern medicine, as it is considered a global epidemic of the XXI century. The disease often leads to the development of serious, health threatening complications. Diabetic foot syndrome is a characteristic set of anatomical and molecular changes. At the macroscopic level, major symptoms are neuropathy, ischemia and chronic ulceration of the lower limb. In every third patient, the neuropathy develops into Charcot neuroarthropathy characterized by bone and joints deformation. Interestingly, all these complications are a result of impaired healing processes and are characteristic for diabetes. The specificity of these symptoms comes from impaired molecular mechanisms observed in type 1 and type 2 diabetes. Decreased wound and fracture healing reflect gene expression, cellular response, cell functioning and general metabolism. Here we present a comprehensive literature update on the molecular factors contributing to diabetic foot syndrome.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 507-513
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
    Autorzy:
    Liberek, Anna
    Kmieć, Zbigniew
    Wierzbicki, Piotr
    Jakóbkiewicz-Banecka, Joanna
    Liberek, Tomasz
    Łuczak, Grażyna
    Plata-Nazar, Katarzyna
    Słomińska-Frączek, Magdalena
    Kaszubowska, Lucyna
    Gabig-Cimińska, Magdalena
    Węgrzyn, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1039466.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Crohn's disease
    ulcerative colitis
    Transforming Growth Factor-β1
    longitudinal assessment of TGF-β1 level
    Opis:
    Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 683-688
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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