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    Wyświetlanie 1-9 z 9
    Tytuł:
    Nowotwory kości : nowe możliwości terapeutyczne
    Bone cancer : new therapeutic possibility
    Autorzy:
    Wyszkowska, Roksana
    Drzeżdżon, Joanna
    Musiał, Claudia
    Górska-Ponikowska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/171964.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    kostniakomięsak
    chrzęstniakomięsak
    włókniakomięsak
    tlenek azotu
    2-metoksyestradiol
    osteosarcoma
    chondrosarcoma
    fibrosarcoma
    nitric oxide
    2-methoxyestradiol
    Opis:
    Among bone tumours, Osteosarcoma (OS), Chondrosarcoma (CS) and Fibrosarcoma (FS) are highly metastatic with poor prognostic for survival. Standard procedures as surgery resection, radiotherapy and chemotherapy do not lead to full recovery or they do not affect metastasis [1-4]. Nowadays new molecular targets to cure cancer are during clinical trials. Clinical trials for OS are focused on using monoclonal antibody (dinutuximab) [5], immunotherapy (as using GM-CSF with influence on white blood cells) [6] or compounds acting as VEGFR inhibitor or PDGFR inhibitor - to reduce metastasis [7-9]. Clinical trials for CS are targeting the hedgehog pathway, focused on its inhibition [10], inhibition of IDH1/2 (common mutation in CS leading to hypermethylation) [11] or, as in OS treatment, inhibition of metastasis by acting on VEGFR [12]. Beyond new chemotherapy and chemotherapy correlated with radiotherapy [13] clinical trials for FS are targeting gene fusion NTRK acting through inhibition of tropomyosin kinase receptor [14]. This approach to treatment is a novelty on the global scale [15]. Nitric oxide (NO) has many biological functions, e.g.: acting as neurotransmitter, reduced aggregation of platelets, acting as EDRF or reducing the oxidative stress in tumours [16-18]. Due to the dual nature of NO [19] anti-proliferative, pro-apoptotic and cell cycle arrest effect of NO were observed [20-25]. It could be a new area to find novel anti-cancer compound. One of the molecular targets under the scientists consideration is the activation of nitric oxide synthase (NOS). Górska-Ponikowska et al. [26-28] focused on experiments on OS 143B cells with 2-methoxyestradiol (2-ME) treatment, potentially novel compound playing the role of n-NOS activator. The researchers reported influence of 2-ME on down-regulation of mitochondrial biogenesis via direct influence on n-NOS level in OS 143B cells. What is more, L-lactate was indicated as potential molecular marker of anticancer therapy of tumours with metastasis.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 11-12; 701-713
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Czynniki wirulencji bakterii - białkowe fosfatazy tyrozynowe : jako cel terapeutyczny w odpowiedzi na rozwijającą się antybiotykooporność
    Protein tyrosine phosphatases - factors of bacterial virulence : as a therapeutic target in response to increasing antibiotic resistance
    Autorzy:
    Kostrzewa, Tomasz
    Styszko, Joanna
    Przychodzeń, Paulina
    Kamm, Anna
    Górska-Ponikowska, Magdalena
    Kuban-Jankowska, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/171488.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antybiotykooporność
    czynniki wirulencji bakterii
    białkowe fosfatazy tyrozynowe
    inhibitory PTPs
    antibiotic resistance
    virulence factors
    protein tyrosine phosphatases
    PTPs inhibitors
    Opis:
    Microbial virulence is the ability of pathogen to penetrate, replicate, multiplícate and, as a consequence, damage the cells of the infected organism. In recent years, rapid progress in bacterial genome sequencing has led to the discovery and characterization of many new virulence factors. One of the many mechanisms of bacterial virulence is the activity of bacterial kinases and phosphatases. These enzymes phosphorylate and dephosphorylate various amino acid residues in proteins, most commonly serine, tyrosine and threonine. Reversible phosphorylation and dephosphorylation can control the activity of target proteins, either directly, by inducing conformational changes in proteins, or indirectly, by regulating protein-protein interactions. Due to the increasing antibiotic resistance, new substances that could be used to treat diseases caused by resistant bacterial strains are sought. One of the possibilities seems to be the inhibition of bacterial tyrosine phosphatases. Phosphorylation of proteins containing tyrosine residues is a key post-translational modification that controls the numerous cellular functions in bacteria. So far, many tyrosine phosphatases have been found to be responsible for the virulence of various bacterial strains. Many bacterial species use protein tyrosine phosphatases activity in host-pathogen interaction, by affecting signalling pathways and subsequent induction of the infection process. Many studies are devoted to the search for tyrosine phosphatases inhibitors in the context of possible support of the current antibacterial treatment. This article presents a review of reports on bacterial virulence factors-protein tyrosine phosphatases as potential therapeutic targets.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 11-12; 679-699
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Orzeczenia ultra vires Trybunału Sprawiedliwości Unii Europejskiej i ich ocena w orzecznictwie niemieckiego Federalnego Trybunału Konstytucyjnego. Uwagi na marginesie orzeczenia z 5 maja 2020 r.
    Ultra vires Rulings of the Court of Justice of the European Union and their Assessment in the Jurisprudence of the German Federal Constitutional Court. Aside from the Judgment of May 5, 2020
    Autorzy:
    Górska-Szymczak, Joanna
    Górski, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/1927179.pdf
    Data publikacji:
    2021-06-30
    Wydawca:
    Wydawnictwo Adam Marszałek
    Tematy:
    Federalny Trybunał Konstytucyjny
    Trybunał Sprawiedliwości Unii
    Europejskiej
    prawo europejskie
    Europejski Bank Centralny
    Federal Constitutional Court
    Court of Justice of the European Union
    European Law
    European Central Bank
    Opis:
    5 maja 2020 r. Niemiecki Federalny Trybunał Konstytucyjny (FCC) orzekł o legalności programu zakupu aktywów sektora publicznego ustanowionego przez Europejski System Banków Centralnych (ESBC). Co szczególnie istotne, kwestia ta była przedmiotem orzeczenia w trybie prejudycjalnym Trybunału Sprawiedliwości Unii Europejskiej (TSUE), wydanego w następstwie zapytania niemieckiego sądu. Decyzja FCC ma szczególne znaczenie w kontekście planów uruchomienia Europejskiego Funduszu Odbudowy w celu zwalczania skutków pandemii koronawirusa. Niemiecki sąd zakwestionował traktatowe podstawy decyzji Europejskiego Banku Centralnego (EBC), na podstawie których wyemitowano obligacje. Co szczególnie istotne, niemiecki sąd podkreślił nie tylko prawo, ale wręcz obowiązek zbadania przez sądy konstytucyjne państw UE, czy działalność instytucji europejskich wykracza poza uprawnienia przyznane im w traktatach (ultra vires).
    On May 5, 2020, the German Federal Constitutional Court (FCC) ruled on the legality of the public sector asset purchase program established by the European System of Central Banks (ESCB). What is particularly important, this issue was the subject of a preliminary ruling by the Court of Justice of the European Union (CJEU), issued following an inquiry from a German court. The FCC’s decision is of particular importance in the context of plans to launch a European Reconstruction Fund to combat the effects of the coronavirus pandemic. The German court questioned the treaty bases of the decisions of the European Central Bank (ECB) on the basis of which the bonds were issued. What is particularly important, the German court emphasized not only the right, but even the obligation to examine by the constitutional courts of the EU Member States whether the activity of European institutions goes beyond the powers conferred on them in the treaties (ultra vires). The content of this decision and its extensive justification will certainly have a great impact on the functioning of the European Union.
    Źródło:
    Przegląd Prawa Konstytucyjnego; 2021, 3 (61); 343-361
    2082-1212
    Pojawia się w:
    Przegląd Prawa Konstytucyjnego
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A partial refining of the Erdos-Kelly regulation
    Autorzy:
    Górska, Joanna
    Skupień, Zdzisław
    Powiązania:
    https://bibliotekanauki.pl/articles/255598.pdf
    Data publikacji:
    2019
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    inducing A-regulation
    cost of regulation
    Opis:
    The aim of this note is to advance the refining of the Erdos-Kelly result on graphical inducing regularization. The operation of inducing regulation (on graphs or multigraphs) with prescribed maximum vertex degree is originated by D. Konig in 1916. As is shown by Chartrand and Lesniak in their textbook Graphs & Digraphs (1996), an iterated construction for graphs can result in a regularization with many new vertices. Erdos and Kelly have presented (1963, 1967) a simple and elegant numerical method of determining for any simple n-vertex graph G with maximum vertex degree Δ, the exact minimum number, say 0 = 0(G), of new vertices in a Δ-regular graph H which includes G as an induced subgraph. The number 0(G), which we call the cost of regulation of G, has been upper-bounded by the order of G, the bound being attained for each n ≥ 4, e.g. then the edge-deleted complete graph Kn — e has 0 = n. For n ≥ 4, we present all factors of Kn with 6 = n and next 0 = n — 1. Therein in case 0 = n — 1 and n odd only, we show that a specific extra structure, non-matching, is required. Keywords: inducing A-regulation, cost of regulation.
    Źródło:
    Opuscula Mathematica; 2019, 39, 3; 355-360
    1232-9274
    2300-6919
    Pojawia się w:
    Opuscula Mathematica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Extremal Irregular Digraphs
    Autorzy:
    Górska, Joanna
    Skupień, Zdzisław
    Dziechcińska-Halamoda, Zyta
    Majcher, Zofia
    Michael, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/31342278.pdf
    Data publikacji:
    2018-08-01
    Wydawca:
    Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
    Tematy:
    irregular digraph
    oriented graph
    minimal subdigraph
    maximal subdigraph
    asymptotic size
    Opis:
    A digraph is called irregular if its distinct vertices have distinct degree pairs. An irregular digraph is called minimal (maximal) if the removal of any arc (addition of any new arc) results in a non-irregular digraph. It is easily seen that the minimum sizes among irregular n-vertex whether digraphs or oriented graphs are the same and are asymptotic to $ (\sqrt{2} // 3) n^{3//2} $; maximum sizes, however, are asymptotic to $ n^2 $ and $ n^2 // 2 $, respectively. Let s stand for the sum of initial positive integers,$s = 1, 3, 6, .... $ An oriented graph $ H_s $ and a digraph $ F_s $, both large (in terms of the size), minimal irregular, and on any such s vertices, $ s \ge 21 $, are constructed in [Large minimal irregular digraphs, Opuscula Math. 23 (2003) 21–24], co-authored by Z. D-H. and three more of the present co-authors (Z.M., J.M., Z.S.). In the present paper we nearly complete these constructions. Namely, a large minimal irregular digraph $ F_n $, respectively oriented graph $ H_n $, are constructed for any of remaining orders $n$, $n > 21$, and of size asymptotic to $ n^2 $, respectively to $ n^2 // 2$. Also a digraph $ \Phi_n $ and an oriented graph $ G_n $, both small maximal irregular of any order $ n \ge 6 $, are constructed. The asymptotic value of the size of $ G_n $ is at least $ ( \sqrt{2} // 3) n^{3//2} $ and is just the least if $ n = s \rightarrow \infty $, but otherwise the value is at most four times larger and is just the largest if $ n = s − 1 \rightarrow \infty $. On the other hand, the size of $ \Phi_n $ is of the asymptotic order $ \Theta (n^{3//2} ) $.
    Źródło:
    Discussiones Mathematicae Graph Theory; 2018, 38, 3; 791-800
    2083-5892
    Pojawia się w:
    Discussiones Mathematicae Graph Theory
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Presurgical techniques for the treatment of cleft lip and palate in infants – a review of the literature
    Autorzy:
    Górska, Joanna
    Kalinowska, Jolanta
    Racka-Pilszak, Bogna
    Powiązania:
    https://bibliotekanauki.pl/articles/25721355.pdf
    Data publikacji:
    2022-07-12
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    nasoalveolar molding
    infant
    cleft lip
    cleft palate
    presurgical orthopaedics
    Opis:
    Patients with cleft lip and palate require long-term, multistage and multidisciplinary treatment whose first step is presurgical orthopaedic treatment (PSO). The reconstruction of the lip, alveolar process and nose in these patients are major plastic surgery challenges. Various presurgical procedures are undertaken to achieve optimal surgical outcomes. The aim of this article is to present selected techniques for the presurgical cleft lip and palate treatment in infants and critically evaluate the benefits, limitations and drawbacks of the methods used. The research was based on the literature review using keywords: presurgical treatment of cleft lip and palate in infants, presurgical orthopaedics in the treatment of cleft lip and palate in infants in PubMed, Google Scholar databases, and publications in orthodontics and infant orthopaedics out of these databases. PSO is a minimally invasive therapy performed between birth and first surgery. Anatomical and functional cleft palate disorders constitute indications for PSO. There are positive reports on PSO techniques and some of them can be implemented by the child’s caregivers at home. The authors of studies disagree on the PSO effectiveness. The lack of long-term research results, high costs of therapy and few therapy centres negatively influence the decision to undertake the therapy.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2022, 5, 2; 67-74
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE INFLUENCE OF THE WORKER RIGHTS OMBUDSMAN ON MORAL STANDARDS IN THE ORGANIZATION [PWPW]
    Rzecznik praw pracowniczych w Polskiej Wytwórni Papierów Wartościowych S.A.
    Autorzy:
    Górska, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/598166.pdf
    Data publikacji:
    2010-04-15
    Wydawca:
    Instytut Pracy i Spraw Socjalnych
    Źródło:
    Zarządzanie Zasobami Ludzkimi; 2010, 2(73); 71-76
    1641-0874
    Pojawia się w:
    Zarządzanie Zasobami Ludzkimi
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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