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Wyszukujesz frazę "Górniak, Agata Maria" wg kryterium: Autor

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Characterisation and dissolution properties of ketoprofen in binary solid dispersion with chitosan
    Autorzy:
    Grimling, Bożena
    Górniak, Agata
    Meler, Jan
    Szcześniak, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1035185.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    different molecular weights of chitosan
    dissolution
    ketoprofen
    solid dispersion prepared solvent evaporation
    Opis:
    BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 23-31
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034797.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    dissolution
    ibuprofen
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
    Autorzy:
    Grimling, Bożena
    Jasińska, Justyna
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz M.
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034642.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    XRPD
    chitosan
    clotrimazole
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of a dental formulation prepared with chitosan on the pharmaceutical availability of clotrimazole
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Kocoń, Martyna
    Karolewicz, Bożena
    Złocińska, Adrianna
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034568.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    carrier XRPD
    chitosan
    clotrimazole
    hydrogel
    solid dispersion
    Opis:
    The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 42-53
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Empirical Verification of the Occurrence of Lucas Paradox in the Region of Central – Eastern Europe
    Autorzy:
    Górniak, Agata Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1022972.pdf
    Data publikacji:
    2021-03-31
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    International Economics
    International Capital Flows
    International Investment
    Long-Term Capital Movements
    Foreign Direct Investment
    Opis:
    The purpose of this article is to study the occurrence of the Lucas paradox in the region of Central-Eastern Europe. According to the research conducted by Robert Lucas (1990), the direction of the international capital flows is different than the neoclassical theory suggests. The capital does not flow from the richer, high-income economies to the poorer, but rather stays in those with the higher capital resources or flows to the other ones with similar level of GDP. The paper verifies whether the paradox appears in the region, in the way that it examines the impact of the GDP on the FDI inflows. Additionally, the study implements few basic models with factors that may potentially resolve the puzzle of the capital flows. The study method is based on panel data estimations, initially using pooled OLS, and subsequently using fixed or random effects models as appropriate. The examined economies are the member states of the European Union, from the region of Central-Eastern Europe, and the examined years are 2000-2018. Based on the literature, and the widely emphasized need for differentiating between the types of international capital flows, the article focus is on the foreign direct investment only, as they constitute large part of the whole global capital flows. Results of the research confirm the presence of the paradox in the region in the examined period. Even though the estimation of the additional models helps to remove the effects of the paradox for the region, it does not fully explain under which circumstances the neoclassical theory would be applicable. None of the applied models reverses the sign of the GDP variable to negative, keeping it statistically significant at the same time.
    Źródło:
    Finanse i Prawo Finansowe; 2021, 1, 29; 7-17
    2391-6478
    2353-5601
    Pojawia się w:
    Finanse i Prawo Finansowe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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