Autor: Górka, Joanna - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Metody szacowania parametrów modeli dwuliniowych
The methods of estimating the parameters of bilinear models
Autorzy:: Górka, Joanna
Pietrzak, Bernard
Powiązania:: https://bibliotekanauki.pl/articles/453619.pdf
Data publikacji:: 2011
Wydawca:: Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Katedra Ekonometrii i Statystyki
Tematy:: model dwuliniowy
model GARCH
warunkowa wartość oczekiwana
warunkowa wariancja
Opis:: W artykule przedstawiony zostanie model dwuliniowy, jego budowa, własności oraz metody estymacji. Zaprezentowana zostanie również możliwość opisu modelu dwuliniowego za pomocą modelu przestrzeni stanu. Praktyczne zastosowanie modelu dwuliniowego w połączeniu z modelem GARCH pozwala na jednoczesny opis dwóch własności szeregów finansowych, warunkowej wartości oczekiwanej oraz warunkowej wariancji. Model ten wykorzystano w empirycznej analizie indeksów giełdowych, gdzie dokonano próby opisu logarytmicznych stóp zwrotu. Otrzymane wyniki pozwoliły na porównanie modelu ze strukturą dwuliniową AR( p) −BL(P,Q) −GARCH (r, z) z modem AR( p) −GARCH (r, z) .
In the paper we present stochastic process which is called bilinear process, the structure of the process and its properties. Then we present the representation of the state space for the bilinear model. Finally, we show the methods of estimating the parameters of bilinear models and some empirical examples as well.
Źródło:: Metody Ilościowe w Badaniach Ekonomicznych; 2011, 12, 2; 139-147
2082-792X
Pojawia się w:: Metody Ilościowe w Badaniach Ekonomicznych
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Pentraksyna 3 i jej rola w odbudowie tkanek
Pentraxin 3 and its role in tissue repair
Autorzy:: Górka-Dynysiewicz, Joanna
Zuwała-Jagiełło, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/762591.pdf
Data publikacji:: 2020-03-15
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: gojenie się ran
Pentraksyna 3
przebudowa tkanki
wound healing
Pentraxin 3
tissue remodeling
Opis:: Pentraxin 3 (PTX3) is a member of the long pentraxin family. It is an acute-phase protein produced and released in regions of injury. It belongs to humoral innate immune response. It acts as an indicator and regulator of inflammation, in response to the activity of i.a. proinflammatory cytokines (TNF-α, IL-1β), toll-like receptor (TLR) agonists and lipopolysaccharides. It is synthesised in different types of cells, such as: monocytes, macrophages, dendritic cells, endothelial cells, smooth muscle cells, fibroblasts or adipocytes. PTX3 is also produced during neutrophil differentiation and stored in specific granules of mature neutrophils, ready to be released upon microbial recognition. This multimeric glycoprotein is composed of 381 amino acid residues. It contains the N-terminal domain (18-178 amino acid residues) and the C-terminal domain (179-381 amino acid residues), including the 17-amino-acid signal peptide. Its modular structure enables its various bioactivity. PTX3 removes apoptotic cells during the immune response. PTX3 interacts with components of the hemostatic system and the fibrinolytic cascade, under acidic conditions that occur in damaged tissues. As a result of the interaction with plasminogen and fibrin in the wound, pentraxin 3 promotes the process of fibrinolysis and plays a role in the tissue repair process. Together with chemokines, PTX3 organises the leukocyte recruitment in the region of injury, contributing to the formation of the inflammatory microenvironment and the suppression of the inflammatory response. In many animal models, it has been shown that PTX3 plays a complex, non-redundant role in pathogen resistance, inflammation control and tissue repair, acting as an onco-suppressor gene as well. The diverse bioactivity of PTX3 is probably a result of its capability to interact with a wide spectrum of ligands, including complement components, adhesion molecules, growth factors and extracellular matrix components. The involvement of PTX3 in many biological processes determines it as a potentially important biomarker of many diseases. These studies will prove that pentraxin 3 is involved in tissue regeneration. The involvement of PTX3 in tissue injury / tissue remodelling will highlight the relationship and interaction between homeostasis and resistance. This information helps us to understand why PTX3 may become a potential diagnostic marker of the severity of illness related to tissue remodeling, as well as it provides sufficient evidence for using this protein as a therapeutic tool. A better understanding of the complex mechanisms, in which pentraxin 3 is involved, should be sought. ..
STRESZCZENIE. Pentraksyna 3 (PTX3) jest przedstawicielem długiej rodziny pentraksyn. Jest białkiem ostrej fazy produkowanym i uwalnianym w miejscach uszkodzenia. Należy do humoralnej odporności wrodzonej. Działa jako wskaźnik i regulator zapalenia. PTX3 usuwa komórki apoptotyczne podczas odpowiedzi immunologicznej. PTX3 oddziałuje ze składnikami układu hemostatycznego i kaskadą fibrolityczną, w warunkach kwasowych, które występują w uszkodzonych tkankach. W wyniku reakcji z plazminogenem i fibryną w miejscu zranienia pentraksyna 3 promuje proces fibrynolizy i pełni rolę w procesie naprawy tkanek.
Źródło:: Farmacja Polska; 2020, 76, 2; 65-72
0014-8261
2544-8552
Pojawia się w:: Farmacja Polska
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Alterations in protein secretion caused by metabolic engineering of glycosylation pathways in fungi
Autorzy:: Kruszewska, Joanna
Perlińska-Lenart, Urszula
Górka-Nieć, Wioletta
Orłowski, Jacek
Zembek, Patrycja
Palamarczyk, Grażyna
Powiązania:: https://bibliotekanauki.pl/articles/1040697.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: glycosylation
protein secretion
Trichoderma
Opis:: Due to its natural properties, Trichoderma reesei is commonly used in industry-scale production of secretory proteins. Since almost all secreted proteins are O-glycosylated, modulation of the activity of enzymes of the O-glycosylation pathway are likely to affect protein production and secretion or change the glycosylation pattern of the secreted proteins, altering their stability and biological activity. Understanding how the activation of different components of the O-glycosylation pathway influences the glycosylation pattern of proteins and their production and secretion could help in elucidating the mechanism of the regulation of these processes and should facilitate creation of engineered microorganisms producing high amounts of useful proteins. In this review we focus on data concerning Trichoderma, but also present some background information allowing comparison with other fungal species.
Źródło:: Acta Biochimica Polonica; 2008, 55, 3; 447-456
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Disruption of Trichoderma reesei gene encoding protein O-mannosyltransferase I results in a decrease of the enzyme activity and alteration of cell wall composition
Autorzy:: Górka-Nieć, Wioletta
Pniewski, Michał
Kania, Anna
Perlińska-Lenart, Urszula
Palamarczyk, Grażyna
Kruszewska, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/1040737.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Trichoderma reesei
pmt1 gene disruption
protein glycosylation
cell wall composition
Opis:: In fungi transfer of the first mannosyl residue to proteins during their O-glycosylation is catalyzed by protein O-mannosyltransferases encoded by pmt genes. Disruption of the pmt1 gene in Trichoderma caused a significant decrease in the total activity of protein O-mannosyltransferases. Moreover, disruption of the pmt1 gene also led to osmotic sensitivity of the strain, indicating an essential role of the PMTI protein activity for cell wall synthesis. At the same time, the strain was defective in septa formation, producing only half the number of septa per unit length of hypha compared with the wild type. Disruption of the pmt1 gene decreased protein secretion but had no effect on glycosylation of secreted proteins, which suggests that PMTI protein O-mannosyltranferase does not take part in glycosylation of these proteins.
Źródło:: Acta Biochimica Polonica; 2008, 55, 2; 251-259
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
Autorzy:: Horwacik, Irena
Durbas, Małgorzata
Boratyn, Elżbieta
Sawicka, Anna
Węgrzyn, Paulina
Krzanik, Sylwia
Górka, Anna
Drożniak, Joanna
Augustyniak, Ewa
Kowalczyk, Aleksandra
Rokita, Hanna
Powiązania:: https://bibliotekanauki.pl/articles/1038977.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: doxorubicin
GD2 ganglioside
microarray
14G2a
neuroblastoma
mimitin
Opis:: Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
Źródło:: Acta Biochimica Polonica; 2015, 62, 3; 423-433
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki