- Tytuł:
- Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant
- Autorzy:
-
Bahr, Debra E.
Aldrich, Timothy E.
Seidu, Dazar
Brion, Gail M.
Tollerud, David J.
Muldoon, Susan
Reinhart, Nancy
Youseefagha, Ahmed
McKinney, Paul
Hughes, Therese
Chan, Caroline
Rice, Carol
Brewer, David E.
Freyberg, Ronald W.
Mohlenkamp, Adriane M.
Hahn, Kristen
Hornung, Richard
Ho, Mona
Dastidar, Aniruddha
Freitas, Samantha
Saman, Daniel
Ravdal, Hege
Scutchfield, Douglas - Powiązania:
- https://bibliotekanauki.pl/articles/2185472.pdf
- Data publikacji:
- 2011-03-01
- Wydawca:
- Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
- Tematy:
-
cohort study
gaseous diffusion plant
trichloroethylene
Healthy Worker Effect - Opis:
- Objective: The Paducah Gaseous Diffusion Plant (PGDP) became operational in 1952; it is located in the western part of Kentucky. We conducted a mortality study for adverse health effects that workers may have suffered while working at the plant, including exposures to chemicals. Materials and Methods: We studied a cohort of 6820 workers at the PGDP for the period 1953 to 2003; there were a total of 1672 deaths to cohort members. Trichloroethylene (TCE) is a specific concern for this workforce; exposure to TCE occurred primarily in departments that clean the process equipment. The Life Table Analysis System (LTAS) program developed by NIOSH was used to calculate the standardized mortality ratios for the worker cohort and standardized rate ratio relative to exposure to TCE (the U.S. population is the referent for ageadjustment). LTAS calculated a significantly low overall SMR for these workers of 0.76 (95% CI: 0.72–0.79). A further review of three major cancers of interest to Kentucky produced significantly low SMR for trachea, bronchus, lung cancer (0.75, 95% CI: 0.72–0.79) and high SMR for Non-Hodgkin’s lymphoma (NHL) (1.49, 95% CI: 1.02–2.10). Results: No significant SMR was observed for leukemia and no significant SRRs were observed for any disease. Both the leukemia and lung cancer results were examined and determined to reflect regional mortality patterns. However, the Non-Hodgkin’s Lymphoma finding suggests a curious amplification when living cases are included with the mortality experience. Conclusions: Further examination is recommended of this recurrent finding from all three U.S. Gaseous Diffusion plants.
- Źródło:
-
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 1; 67-77
1232-1087
1896-494X - Pojawia się w:
- International Journal of Occupational Medicine and Environmental Health
- Dostawca treści:
- Biblioteka Nauki
Artykuł