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    Wyświetlanie 1-6 z 6
    Tytuł:
    Cellulose as a matrix for synthesis of the library of molecular receptors useful for screening of antihistamine compounds
    Autorzy:
    Walczak, M. E.
    Fraczyk, J.
    Kaminski, Z. J.
    Kolesinska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/285804.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biopolymers
    antihistamine compounds
    molecular receptors
    Źródło:
    Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 50
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Functionalized cellulose as a matrix for the synthesis of library of molecular receptors useful for screening of compounds with anti-histamine activity
    Autorzy:
    Walczak, M. E.
    Frączyk, J.
    Kamiński, Z. J.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/285956.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    molecular receptors
    immobilized peptides
    binding pocket
    agonist/antagonist
    histamine receptors
    Opis:
    The library of molecular receptors was formed by self-organization of N-heptanoylated dipeptides anchored in the regular fashion via aminophenylamino- 1,3,5-triazine linker to the surface of cellulose membrane. SPOT method was used for the synthesis of peptide library. As C-terminal amino acids of peptide fragments were attached: Ala, Pro and Phe, while as a N-terminal amino acids were applied all natural amino acids. DMT/NMM/TosO- was selected as a coupling reagent for synthesis of library of N-heptanoylated dipeptides. These constructs were used as a tool for distinguishing pharmaceutically active compounds acting on histamine receptors. In the studies as active compounds were tested: Doxylamine and Difenhydramine with histamine agonist activity, Ranitidine and Cimetidine with antagonist activity as well as Histamine – natural ligand. The binding of colourless ligands was monitored by staining with Brilliant Black used as reporter dye and quantitative colour measurement was performed in 256 grade gray scale by using Image-Quant software. Substantial differences in the ability of interactions of agonists and antagonists with bounding pockets were observed with selected molecular receptors. From 60 elements library of molecular receptors were selected 12, which were able to distinguish between agonists or antagonists. It has been found that even small changes (Leu residue vs Val residue) in the structure of molecular receptor influenced specificity of agonist or antagonist binding.
    Źródło:
    Engineering of Biomaterials; 2017, 20, 142; 2-6
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination
    Autorzy:
    Mitura, K.
    Wilczek, P.
    Niemiec-Cyganek, A.
    Morenc, M.
    Dudek, M.
    Sobczyk-Guzenda, A.
    Fraczyk, J.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/284974.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    detonation nanodiamond particles
    chemical modification
    anti-inflammatory drugs
    FTIR spectroscopy
    mouse fibroblasts
    Opis:
    Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.
    Źródło:
    Engineering of Biomaterials; 2017, 20, 140; 12-20
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selection of active fragments of collagen
    Autorzy:
    Kolesińska, B.
    Frączyk, J.
    Kamński, Z. J.
    Rosiak, P.
    Becht, A.
    Czerchawy, A.
    Chaberska, A.
    Waśko, J.
    Czerczak, K.
    Walczak, M. E.
    Powiązania:
    https://bibliotekanauki.pl/articles/286048.pdf
    Data publikacji:
    2018
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    collagen
    regeneration
    biocompatibility
    Źródło:
    Engineering of Biomaterials; 2018, 21, 148; 41
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Angiostrongylus vasorum - nicień płucny, nowe zagrożenie dla psów w Polsce
    Angiostrongylus vasorum - canine lungworm, new threat for dogs in Poland
    Autorzy:
    Fraczyk, M.
    Gawor, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/859660.pdf
    Data publikacji:
    2014
    Wydawca:
    Krajowa Izba Lekarsko-Weterynaryjna
    Tematy:
    psy
    zagrozenia zdrowia
    choroby zwierzat
    choroby inwazyjne
    angiostrongyloza
    nicienie
    Angiostrongylus vasorum
    cykl rozwojowy
    wystepowanie
    objawy chorobowe
    diagnostyka
    leczenie
    Źródło:
    Życie Weterynaryjne; 2014, 89, 02
    0137-6810
    Pojawia się w:
    Życie Weterynaryjne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose
    Autorzy:
    Fraczyk, Justyna
    Walczak, Małgorzata
    Balcerzak, Waldemar
    Pokajewicz, Katarzyna
    Wieczorek, Piotr
    Młynarski, Wojciech
    Fendler, Wojciech
    Kaminski, Zbigniew J.
    Powiązania:
    https://bibliotekanauki.pl/articles/895507.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    surface modification
    cancer markers
    chemical receptor
    molecular mono-layer
    immobilized peptides
    Opis:
    A novel diagnostic method based on recognition of qualitative and quantitative composition of healthy and tumor tissue samples by library of molecular receptors was presented. Molecular receptors were formed by self-organization of N-lipidated peptides attached in the regular fashion via aminophenylamino-1,3,5-triazine linker to the surface of cellulose plate. For samples testing, the library was cloned into multiple, identical copies and for each experiment the new clone was used. The binding process was monitored by staining the discs with Brilliant Black and quantitative color measurement was performed in 256 grade gray scale. Substantial differences in the composition of healthy and tumor samples were observed in most cases. The highly individual chemical fingerprints were found to be reliant on the cancer type. For malignant papillary thyroid cancer statistical analysis identified two receptors most useful for diagnostic purposes.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 1017-1029
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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