Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Famulski, W." wg kryterium: Autor

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-3 z 3
    Tytuł:
    Systemic inflammation markers in blood samples of colorectal cancer patients
    Autorzy:
    Grudzińska, M.
    Jakubowska, Katarzyna
    Koda, M.
    Koda, L.
    Kisielewski, W.
    Smereczański, N.
    Rogoz-Jezierska, N.
    Famulski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918917.pdf
    Data publikacji:
    2020-06-10
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    neutrophil-to-monocyte ratio
    monocytetolymphocyte ratio
    Opis:
    Introduction: Colorectal cancer (CRC) is one of the most common cancers in Poland. The aim of this study was to investigate the clinical significance of absolute monocyte count, neutrophil-to-monocyte ratio (NMR) and monocytetolymphocyte ratio (MLR) in pre- and postoperative blood samples of patients with CRC. Materials and Methods: We retrospectively reviewed medical records of 160 patients diagnosed with CRC who underwent surgery. Blood samples were obtained within 3 days before and after the surgical treatment. Venous blood samples were also obtained from 42 healthy controls. Results: Pre- and postoperative NMR were significantly higher than healthy controls (p<0.0001; p<0.0001). Moreover, MLR in pre-and postoperative blood samples were higher than voluntaries (p<0.001; p<0.001). The area under the ROC curve for pre and postNMR showed that the parameter exhibits strong diagnostic power (1.000). Pre- and postMLR had moderate diagnostic power amount 0.751 and 0.746. There is also correlation between monocyte count in samples obtained before and after surgery and, lymph node metastasis and size of lymph node metastasis in both cases. PreNMR value was significantly associated with venous and lymphatic invasion and the presence of cancer deposits. PostNMR was found to correlate with presence of distant metastasis and cancer cell deposits (R=0.633, p<0.001; R=0.158, p=0.040). Moreover, preMLR value was correlated with only perineural invasion. Conclusions: Analyzed hematologic markers may be useful as simply obtained parameters, next to histopathological examination, that determine a systemic immune response
    Źródło:
    Progress in Health Sciences; 2020, 10(1); 92-101
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The expression of apoptosis-related proteins in patients with ulcerative colitis
    Autorzy:
    Niewiarowska, K.
    Lebelt, A.
    Gryko, M.
    Pryczynicz, A.
    Famulski, W.
    Czyżewska, J.
    Kemona, A.
    Piekarska-Dymicka, V.
    Jagodzińska, D.
    Guzińska-Ustymowicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1916338.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Ulcerative colitis
    Bcl-xl
    Bax
    Bid
    Bcl-2
    Opis:
    Purpose: Recent literature data indicate a key role of apoptosis in the pathogenesis of inflammatory bowel disease. The aim of the study was to evaluate the expression of Bax, Bid, Bcl-2 and Bcl-xl in non-dysplastic and dysplastic epithelium in inflamated mucosa of patients with ulcerative colitis. Methods: The study consists of 18 patients with diagnosed ulcerative colitis. The expression of proteins was determined immunohistochemically. Results: Lack of Bax expression in normal epithelium of the inflamed intestinal mucosa (94.4%) and a weak expression of this protein were found in dysplastic glandular cells (67%). The Bax expression of dysplastic epithelium correlates with reduced severity of chronic inflammation (p<0.005). Bid expression in non-dysplastic glands was found in 67% of cases vs. 16% in dysplastic epithelium that was associated with the occurrence of epithelial erosions or ulcers (p<0.05). Moderate cytoplasmic expression of Bcl-xl was noted in 27.7% of patients in normal epithelium and in 66.1% within dysplastic lesions. Bcl-xl expression in dysplastic glandular cells correlated with the presence of neutrophils in the lamina propria (p <0.05). Conclusions: The immunohistochemical expressions of Bax, Bcl-2 and Bcl-xl increase and Bid protein expression decreases in dysplastic glandular tubes as compared to non-dysplastic intestinal epithelium in inflamed mucosa, which may suggest an imbalance of controlled cell death in ulcerative colitis.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 75-82
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
    Autorzy:
    Grudzińska, M.
    Jakubowska, K.
    Kańczuga-Koda, L.
    Kisielewski, W.
    Famulski, W.
    Smereczański, N.M.
    Lomperta, K.
    Płoński, M.A.
    Rogoz-Jezierska, N.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918914.pdf
    Data publikacji:
    2020-06-10
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    inflammatory cells
    fibrosis
    Opis:
    Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2020, 10(1); 69-76
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies