Autor: Escribano, Elvira - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: NLCs as a potential carrier system for transdermal delivery of forskolin
Autorzy:: Lasoń, Elwira
Sikora, Elżbieta
Miastkowska, Małgorzata
Escribano, Elvira
Garcia-Celma, Maria
Solans, Conxita
Llinas, Meritxell
Ogonowski, Jan
Powiązania:: https://bibliotekanauki.pl/articles/1038376.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Forskolin
NLC
nanostructured lipid carrier
skin permeation
Opis:: Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 437-442
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Nano-emulsions as vehicles for topical delivery of forskolin
Autorzy:: Miastkowska, Małgorzata
Sikora, Elżbieta
Lasoń, Elwira
Garcia-Celma, Maria
Escribano-Ferrer, Elvira
Solans, Conxita
Llinas, Meritxell
Powiązania:: https://bibliotekanauki.pl/articles/1038566.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Forskolin
nano-emulsions
medium chain triglycerides
in vitro skin permeation
Opis:: Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25°C. Studies of forskolin in vitro skin permeation from the nano-emulsions and from a triglyceride solution were carried out at 32°C, using Franz-type diffusion cells. A mixture of PBS/ethanol (60/40 v/v) was used as a receptor solution. The highest flux and permeability coefficient was obtained for the system stabilized with Polysorbate 80 (6.91±0.75 µg · cm-2·h-1 and 9.21 · 10-3±1.00 · 10-3 cm · h-1, respectively) but no significant differences were observed with the flux and permeability coefficient value of forskolin dissolved in oil. The obtained results showed that the nano-emulsions developed in this study could be used as effective carriers for topical administration of forskolin.
Źródło:: Acta Biochimica Polonica; 2017, 64, 4; 713-718
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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