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Wyświetlanie 1-2 z 2
Tytuł:
Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review
Autorzy:
Igbe, I.
Edosuyi, O.
Okhuarobo, A.
Powiązania:
https://bibliotekanauki.pl/articles/71422.pdf
Data publikacji:
2018
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
ethnomedicine
medicinal plant
Cussonia barteri
Araliaceae
isolated compound
phytochemical constituent
medicinal property
drug development
Opis:
Cussonia barteri Seem (Araliaceae) is a deciduous tree growing in savannah of Africa. Ethnomedicinally, it is used in Africa as an analgesic, anti-malarial, anti-inflammatory, anti-anaemic, anti-diarhoea, anti-poison, ani-pyschotic and anti-epileptic agent. This review provides a brief summary on the phytochemical screenings, ethnomedicinal and pharmacological applications of various parts of C. barteri. Leaves, stem bark and seed of C. barteri have been shown to be rich in saponins, flavonoids, phenols, sugars and alkaloids. Some of these constituents have been isolated and elucidated from C. barteri. Several compounds isolated from plant include triterpenes, saponins, polyenyne and quinic esters. Phytochemical constituents are also partly responsible for biological activities of C. barteri. Extracts and components isolated from the plant have demonstrated neuropharmacological, anti-larvicidal, anti-microbial, anti-inflammatory and antioxidant activities. Overall, the insights provided by this review reinforce the potential of C. barteri for drug development and create the need for further scientific probe of constituents of the plant with the aim of developing novel drug candidates.
Źródło:
Herba Polonica; 2018, 64, 3
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AMELIORATIVE EFFECTS OF DIMETHYL FUMARATE IN ACUTE AND CHRONIC MURINE MODELS OF DEPRESSION
Autorzy:
Iniaghe, Loretta O.
Okpakpor, Eloho E.
Edosuyi, Osaze O.
Eseka, Ewere O.
Nedozi, Ogugua I.
Powiązania:
https://bibliotekanauki.pl/articles/895421.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
antioxidant
catalase
Forced swim test
chronic unpredictable mild stress
sucrose preference
thiobarbituric reactive acid substance
Opis:
Depression, a major contributor to the global disease burden, occurs in both adults and children, and is associated with impaired antioxidant defense mechanisms. This study examined the effects of dimethyl fumarate (DMF), a fumaric acid ester with immunomodulatory, anti-inflammatory and antioxidant properties in murine models of depression. In the first phase of the study, mice were treated with the either the vehicle, 50 and 100 mg/kg DMF or 15 mg/kg imipramine and subjected to either the forced swim or tail suspension tests. Thereafter, mice were euthanized and levels of antioxidant markers in isolated brain tissues were assayed. In the second phase of the study, mice were subjected to the chronic unpredictable mild stress regimen for four weeks and treated with the vehicle, DMF or imipramine in the last two weeks of the stress protocol. Forced swim and percentage sucrose preference tests were used for behavioural evaluations. Mice were sacrificed, brain levels of catalase, glutathione, thiobarbituric reactive acid substance and nitrite were quantified. Treatment with DMF significantly (p<0.05) reduced periods of immobility in both the forced swim and tail suspension tests following acute and chronic drug treatment and improved sucrose consumption after exposure to chronic unpredictable mild stress. DMF also significantly improved (p<0.05) levels of antioxidants (catalase and glutathione) while reducing prooxidant biomarkers (thiobarbituric reactive acid substance and nitrite levels) in the brain. DMF ameliorated depression in mice and augmented the antioxidant defense mechanism in the brains of mice subjected to chronic unpredictable mild stress.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1399-1407
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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