Autor: Dzierzbicka, K. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Synteza analogów adenozyny
Synthesis of adenosine analogues
Autorzy:: Samsel, M.
Dzierzbicka, K.
Powiązania:: https://bibliotekanauki.pl/articles/172542.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: adenozyna
receptory dla adenozyny
analogi adenozyny
aktywność biologiczna
adenosine
adenosine receptors
synthesis
adenosine analogues
biological activity
Opis:: Adenosine (Rys. 1) is a purine nucleoside playing an important role in human body. It is involved in key pathways such as purinergic nucleic acid base synthesis, amino acid metabolism and modulation of cellular metabolic status [1,2]. Adenosine acts through the four types of adenosine receptors: A1, A2A, A2B and A3 belonging to the G protein-coupled receptor family [3]. In physiological conditions this nucleoside is present in a micromolar range [5]. However, when metabolic stress occurs extracellular level of adenosine raises revealing its protective properties. Depending on an activated receptor subtype, adenosine demonstrates cardioprotective and neuroprotective activity during hypoxia or ischemia, it stimulates the immunological system [6, 7]. Besides many potential applications, adenosine is used mainly for the treatment of paroxysmal supraventricular tachycardia. Limitations are linked to a very short blood half-time and no receptor specificity [8]. This review is focused on novel literature data about synthesis of adenosine analogues with interesting biological activities. In order to influence adenosine receptor selectivity and pharmacokinetic properties a nucleoside structure can be modified in purine [14, 15, 17, 22, 26, 27, 35] or sugar ring [29, 32]. New interesting compounds are also synthesized by cyclisation of adenosine [36]. Modification of adenosine structure allowed obtaining compounds with targeted action: antiarrhythmic [11, 12], antinociceptive [9], antilipolytic [13], antiviral [29] or anticancer [35].
Źródło:: Wiadomości Chemiczne; 2012, 66, 3-4; 321-340
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Poszukiwanie nowych leków immunosupresyjnych
Quest for new immunosuppressive drugs
Autorzy:: Dzierzbicka, K.
Cholewiński, G.
Iwaszkiewicz-Grześ, D.
Trzonkowski, P.
Powiązania:: https://bibliotekanauki.pl/articles/171863.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: aktywność immunosupresyjna
leki immunosupresyjne
glikokortykosteroidy
takrolimus
CsA
FK506
MPA
kwas mykofenolowy
MMF
MPS
immunosuppressive activity
immunosuppressive drugs
glicocorticosteroids
tacrolimus
Opis:: Transplantology is getting more and more important in medicine. Development of surgical techniques and immunosuppressive treatment enabled to establish successful transplantations with various organs and tissues. However, allografts are recognized as foreign tissues and stimulate rejection, i.e. a strong immunological response which, if not stopped, results in complete destruction of the transplanted tissue. In order to prevent the rejection patients have to be treated with immunosuppressive drugs after transplantation. Unfortunately, such a damping of immune system poses a risk of cancer or severe infections. The treatment itself is also toxic, notably when applied in a long-term maintenance therapy. Currently, adverse effects of immunosuppressive drugs are recognized as the ones to be involved significantly in chronic rejection and limitation of long survival of grafted tissues. Whereas prevention of acute rejection is mostly successful, there is still no efficient treatment for chronic graft rejection. Reduction of a dose of immunosuppressive drugs or an invention of new active substances is considered the most promising solution. Nowadays, immunosuppressive drugs can be divided into the three main groups: agents which inhibit production of cytokines taking part in cells’ activation (glicocorticosteroids, calcineurine inhibitors, mTOR inhibitors), antiproliferative compounds (azathiopirin, mycophenolate mofetil, mycophenolic acid sodium salt), and antibodies. In this article we present new investigations towards immunosuppressive drugs, their structures and synthetic methods.
Źródło:: Wiadomości Chemiczne; 2011, 65, 1-2; 59-92
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Parameterisation of a zero-dimensional pelagic detritus model, Gdańsk Deep, Baltic Sea
Parametryzacja modelu detrutusu pelagicznego, Głębia Gdańska, Morze Bałtyckie
Autorzy:: Kuliński, K.
Maciejewska, A.
Dzierzbicka-Głowacka, L.
Pempkowiak, J.
Powiązania:: https://bibliotekanauki.pl/articles/1819502.pdf
Data publikacji:: 2011
Wydawca:: Politechnika Koszalińska. Wydawnictwo Uczelniane
Tematy:: parametryzacja MDP
Morze Bałtyckie
Głębia Gdańska
stężenie POC
parameterization of MDP
Baltic Sea
Gdańsk Deep
POC concentration
Opis:: This paper presents a zero-dimensional particulate detritus model (Figure 1) and a comprehensive description of parameterisation processes that influence the non-living organic matter (detritus) concentration in the whole water column. Mathematically, the particulate pelagic detritus concentration can be described as a variable dependent on the number of its sources and sinks. Temporal supplies in the pelagic detritus concentration are affected by the natural mortality of phytoplankton and zooplankton as well as by the faecal pellets that enter the detritus pool. On the other hand, sedimentation, grazing of detritus by zooplankton and mineralization of pelagic detritus act as sinks that reduce the detritus concentration in the water column. The aim of this model study was to calibrate the detritus model under the environmental conditions typical of the Gdańsk Deep in the southern Baltic Sea.
Przedmiotem badań jest parametryzacja zero wymiarowego Modelu Detrytusu Pelagicznego (PDM). Stężenie detrytusu pelagicznego w wodzie morskiej jest determinowane równowagą ustaloną pomiędzy źródłami i ubytkami martwej, zawieszonej materii organicznej. Do źródeł zalicza się: śmiertelność fito- i zooplanktonu oraz odchody zooplanktonu. Wśród ubytków detrytusu wyróżnić można natomiast sedymentację, wyżeranie przez zooplankton oraz rozkład biochemiczny. Przedstawione badania opisują oddziaływanie temperatury, stężenia związków biogenicznych, nasłonecznienia oraz biomasy fito- i zooplanktonu na stężenie detrytusu pelagicznego w wodzie morskiej. Parametryzacja przeprowadzona została w typowych dla południowego rejonu Morza Bałtyckiego zakresach zmiennych. Detrytus pelagiczny razem z fito- i zooplanktonem są komponentami niezbędnymi do opisania zmienności stężeń zawieszonego węgla organicznego (POC) będącego istotnym składnikiem obiegu węgla w środowisku morskim. Prawidłowa parametryzacja PDM stanowi zatem podstawę dla numerycznego opisu aktualnej i przyszłej zmienności stężeń POC w wodzie Morza Bałtyckiego.
Źródło:: Rocznik Ochrona Środowiska; 2011, Tom 13; 187-206
1506-218X
Pojawia się w:: Rocznik Ochrona Środowiska
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Particulate organic carbon in the Southern Baltic Sea: numerical simulations and experimental data
Autorzy:: Dzierzbicka-Glowacka, L.
Kulinski, K.
Maciejewska, A.
Jakacki, J.
Pempkowiak, J.
Powiązania:: https://bibliotekanauki.pl/articles/48082.pdf
Data publikacji:: 2010
Wydawca:: Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:: Baltic Sea
Gdansk Deep
calcification
carbon cycle
detritus
nutrient
organic compound
organic matter
particulate organic carbon
photosynthesis
phytoplankton
primary production
sea water
validation
zooplankton
Opis:: Particulate Organic Carbon (POC) is an important component in the carbon cycle of land-locked seas. In this paper, we assess the POC concentration in the Gdańsk Deep, southern Baltic Sea. Our study is based on both a 1D POC Model and current POC concentration measurements. The aim is twofold: (i) validation of simulated concentrations with actual measurements, and (ii) a qualitative assessment of the sources contributing to the POC pool. The POC model consists of six coupled equations: five diffusion-type equations for phytoplankton, zooplankton, pelagic detritus and nutrients (phosphate and total inorganic nitrogen) and one ordinary differential equation for detritus at the bottom. The POC concentration is determined as the sum of phytoplankton, zoo-plankton and pelagic detritus concentrations, all expressed in carbon equivalents. Bacteria are not simulated in this paper. The observed large fluctuations of POC concentrations are attributed to its appreciable seasonal variability. The maximum concentration of POC varied between 870 mgC m−3 in May and 580 mgC m−3 in September, coinciding with the period of maximum dead organic matter and phytoplankton biomass concentrations. The results of the numerical simulations are in good agreement with observed values. The difference between the modelled and observed POC concentrations is equal to 3–28% and depends on the month for which the calculations were made, although no time trend of the difference is observed. The conclusion is that the numerical simulations are a ufficiently good reflection of POC dynamics in the Baltic.
Źródło:: Oceanologia; 2010, 52, 4
0078-3234
Pojawia się w:: Oceanologia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Numerical modelling of POC dynamics in the Southern Baltic under possible future conditions determined by nutrients, light and temperature
Autorzy:: Dzierzbicka-Glowacka, L.
Kulinski, K.
Maciejewska, A.
Jakacki, J.
Pempkowiak, J.
Powiązania:: https://bibliotekanauki.pl/articles/47783.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:: Baltic Sea
detritus
natural mortality
numerical modelling
nutrient
particulate organic carbon
phytoplankton
predator
primary production
temperature
temporal change
zooplankton
Opis:: This paper discusses predictions of particulate organic carbon (POC) concentra- tions in the southern Baltic Sea. The study is based on the one-dimensional Particulate Organic Carbon Model (1D POC), described in detail by Dzierzbicka- Głowacka et al. (2010a). The POC concentration is determined as the sum of phytoplankton, zoo- plankton and dead organic matter (detritus) concentrations. Temporal changes in the phytoplankton biomass are caused by primary production, mortality, grazing by zooplankton and sinking. The zooplankton biomass is affected by ingestion, excretion, faecal production, mortality and carnivorous grazing. The changes in the pelagic detritus concentration are determined by the input of dead phytoplankton and zooplankton, the natural mortality of predators, faecal pellets, and sinks – sedimentation, zooplankton grazing and biochemical decomposition. The model simulations were done for selected locations in the southern Baltic Sea (Gdańsk Deep, Bornholm Deep and Gotland Deep) under predicted conditions characterized by changes of temperature, nutrient concentrations and light availability. The results cover the daily, monthly, seasonal and annual POC concentration patterns in the upper water layer. If the assumed trends in light, nutrients and temperature in the southern Baltic correctly predict the conditions in 2050, our calculations indicate that we can expect a two- to three-fold increase in POC concentration in late spring and a shift towards postponed maximum POC concentration. It can also be anticipated that, as a result of the increase in POC, oxygenation of the water layer beneath the halocline will decrease, while the supply of food to organisms at higher trophic levels will increase.
Źródło:: Oceanologia; 2011, 53, 4
0078-3234
Pojawia się w:: Oceanologia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: SatBałtyk – A Baltic environmental satellite remote sensing system – an ongoing project in Poland. Part 1: Assumptions, scope and operating range
Autorzy:: Wozniak, B.
Bradtke, K.
Darecki, M.
Dera, J.
Dudzinska-Nowak, J.
Dzierzbicka-Glowacka, L.
Ficek, D.
Furmanczyk, K.
Kowalewski, M.
Krezel, A.
Majchrowski, R.
Ostrowska, M.
Paszkuta, M.
Ston-Egiert, J.
Stramska, M.
Zapadka, T.
Powiązania:: https://bibliotekanauki.pl/articles/48960.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:: algal bloom
Baltic ecosystem
Baltic Sea
Baltic water
chlorophyll a
functional property
marine optics
organic matter
phytoplankton pigment
Polska
remote sensing
SatBaltyk project
satellite monitoring
solar radiation
structural property
Opis:: This article is the first of two papers on the remote sensing methods of monitoring the Baltic ecosystem, developed by a Polish team. The main aim of the five- year SatBałtyk (2010–2014) research project (Satellite Monitoring of the Baltic Sea Environment) is to prepare the technical infrastructure and set in motion operational procedures for the satellite monitoring of the Baltic environment. This system is to characterize on a routine basis the structural and functional properties of this sea on the basis of data supplied by the relevant satellites. The characterization and large-scale dissemination of the following properties of the Baltic is anticipated: the solar radiation influx to the sea’s waters in various spectral intervals, energy balances of the short- and long-wave radiation at the Baltic Sea surface and in the upper layers of the atmosphere over the Baltic, sea surface temperature distribution, dynamic states of the water surface, concentrations of chlorophyll a and other phytoplankton pigments in the Baltic water, distributions of algal blooms, the occurrence of upwelling events, and the characteristics of primary organic matter production and photosynthetically released oxygen in the water. It is also intended to develop and, where feasible, to implement satellite techniques for detecting slicks of petroleum derivatives and other compounds, evaluating the state of the sea’s ice cover, and forecasting the hazards from current and future storms and providing evidence of their effects in the Baltic coastal zone. The ultimate objective of the project is to implement an operational system for the routine determination and dissemination on the Internet of the above-mentioned features of the Baltic in the form of distribution maps as well as plots, tables and descriptions characterizing the state of the various elements of the Baltic environment. The main sources of input data for this system will be the results of systematic recording by environmental satellites and also special-purpose ones such as TIROS N/NOAA, MSG (currently Meteosat 9), EOS/AQUA and ENVISAT. The final effects of the SatBałtyk project are to be achieved by the end of 2014, i.e. during a period of 60 months. These two papers present the results obtained during the first 15 months of the project. Part 1 of this series of articles contains the assumptions, objectives and a description of the most important stages in the history of our research, which constitute the foundation of the current project. It also discusses the way in which SatBałtyk functions and the scheme of its overall operations system. The second article (Part 2), will discuss some aspects of its practical applicability in the satellite monitoring of the Baltic ecosystem (see Woźniak et al. (2011) in this issue).
Źródło:: Oceanologia; 2011, 53, 4
0078-3234
Pojawia się w:: Oceanologia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: SatBaltyk – A Baltic environmental satellite remote sensing system – an ongoing project in Poland. Part 2: Practical applicability and preliminary results
Autorzy:: Wozniak, B.
Bradtke, K.
Darecki, M.
Dera, J.
Dudzinska-Nowak, J.
Dzierzbicka-Glowacka, L.
Ficek, D.
Furmanczyk, K.
Kowalewski, M.
Krezel, A.
Majchrowski, R.
Ostrowska, M.
Paszkuta, M.
Ston-Egiert, J.
Stramska, M.
Zapadka, T.
Powiązania:: https://bibliotekanauki.pl/articles/48019.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:: Baltic ecosystem
Baltic Sea
energy influx
irradiance condition
marine optics
photosynthesis
plant community
Polska
practical application
preliminary result
radiation balance
remote sensing
SatBaltyk project
satellite monitoring
sea surface
solar energy
Opis:: This paper is the second part of the description of the first stage of the SatBałtyk project’s implementation. Part 1 (Woźniak et al. 2011, in this issue) presents the assumptions and objectives of SatBałtyk and describes the most important stages in the history of our research, which is the foundation of this project. It also discusses the operation and general structure of the SatBałtyk system. Part 2 addresses various aspects of the practical applicability of the SatBałtyk Operational System to Baltic ecosystem monitoring. Examples are given of the Baltic’s characteristics estimated using the preliminary versions of the algorithms in this Operational System. At the current stage of research, these algorithms apply mainly to the characteristics of the solar energy influx and the distribution of this energy among the various processes taking place in the atmosphere-sea system, and also to the radiation balance of the sea surface, the irradiance conditions for photosynthesis and the condition of plant communities in the water, sea surface temperature distributions and some other marine phenomena correlated with this temperature. Monitoring results obtained with these preliminary algorithms are exemplified in the form of distribution maps of selected abiotic parameters of the Baltic, as well as structural and functional characteristics of this ecosystem governed by these parameters in the Baltic’s many basins. The maps cover practically the whole area of the Baltic Sea. Also given are results of preliminary inspections of the accuracy of the magnitudes shown on the maps. In actual fact, the errors of these estimates are relatively small. The further practical application of this set of algorithms (to be gradually made more specific) is therefore entirely justified as the basis of the SatBałtyk system for the effective operational monitoring of the state and functioning of Baltic ecosystems. This article also outlines the plans for extending SatBałtyk to include the recording of the effects and hazards caused by current and expected storm events in the Polish coastal zone.
Źródło:: Oceanologia; 2011, 53, 4
0078-3234
Pojawia się w:: Oceanologia
Dostawca treści:: Biblioteka Nauki

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