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    Wyświetlanie 1-8 z 8
    Tytuł:
    Mitochondrial uncoupling does not influence the stability of the intracellular signal activating plasma membrane calcium channels.
    Autorzy:
    Zabłocki, Krzysztof
    Makowska, Agnieszka
    Duszyński, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1044178.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Jurkat cells
    store-operated calcium entry
    mitochondrial uncoupling
    thapsigargin
    Opis:
    The effects of various concentrations of thapsigargin, a specific inhibitor of Ca2+-ATPase in the endoplasmic reticulum (ER) membrane, on calcium homeostasis in lymphoidal T cells (Jurkat) were investigated. Preincubation of these cells suspended in nominally calcium-free medium with 0.1 μM thapsigargin resulted in a complete release of Ca2+ from intracellular calcium stores. When the medium was supplemented with 3 mM CaCl2 the cells maintained constantly elevated level of cytosolic Ca2+. However, thapsigargin applied at lower concentration produced only a partial depletion of the stores. For example, in the cells pretreated with 1 nM thapsigargin and suspended in calcium-free medium approximately 75% of the calcium content was released from the intracellular stores. The addition of 3 mM CaCl2 to such cell suspension led to a transient increase in cytosolic calcium concentration, followed by a return to a lower steady-state. This phenomenon, related to the refilling of the ER by Ca2+, allowed to estimate the half-time for the process of cell recovery after activation of store-operated calcium channels. By this approach we have found that carbonyl cyanide m-chlorophenylhydrazone, which has been documented to inhibit calcium entry into Jurkat cells, does not influence the stability of the intracellular signal involved in the activation of store-operated calcium channels.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 1; 157-161
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Participation of phospholipase A2 isoforms in the control of calcium influx into electrically non-excitable cells
    Autorzy:
    Zabłocki, Krzysztof
    Waśniewska, Magdalena
    Duszyński, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1044292.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MDCK cells
    Jurkat cells
    calcium influx
    store-operated channels
    phospholipase A2
    Opis:
    The participation of phospholipase A2 isoforms in capacitative store-operated Ca2+ influx into Jurkat leukemic T and MDCK cells was investigated. Preincubation of Jurkat cells with either bromophenacyl bromide (an inhibitor of secreted phospholipase A2, sPLA2) or Helss (an inhibitor of calcium independent phospholipase A2 - iPLA2) resulted in a significant inhibition of the calcium influx. The extent of this inhibition depended on the pH of the extracellular millieu; it increased with alkalisation. The rate of Ca2+ influx into MDCK cells was reduced by bromophenacyl bromide. Preincubation of these cells with Helss resulted in the stimulation of the influx. These observations suggest the participation of different PLA2 isoforms in the regulation of Ca2+ influx. They also show that the extent that PLA2 isoforms control the influx depends on the pH of the medium. Finally, these data indicate that various phospholipase A2 isoforms may play a role in the control of Ca2+ influx in different cell lines.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 591-599
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In memory of Professor Lech Wojtczak, researcher and person
    Autorzy:
    Nałęcz, Maciej J.
    Duszyński, Jerzy
    Szewczyk, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/704552.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    bioenergetics
    Lech Wojtczak
    The Nencki Institute
    remembrance
    Opis:
    Professor Lech Wojtczak spent his entire scientific life at the Nencki Institute of Experimental Biology PAS, where he worked since 1947. He is the author or co-author of two hundred scientific papers, promoted 15 doctors of science, was the Full Member of PAS and has been awarded with several prizes and honors. Among his students are three successive directors of the Nencki Institute, the authors of the present article. Scientific interests of Professor Lech Wojtczak were always dealing with bioenergectics, a discipline that he led in Poland and Eastern-Central Europe. In particular, his studies focused on the role of fatty acids and their derivatives on bioenergetics, on the regulatory role of surface potential of biomembranes on enzymatic and transport activities, on the regulatory role of calcium and magnesium in mitochondria, on the role of free oxigen radicals in bioenergetics, etc. Apart from being a great scientist, Lech Wojtczak was also a fantastic teacher, and an excellent scientific supervisor. Being well recognized in the world, he was placing members of his research group in foreign laboratories, as well as was sending tchem to courses and conferences. This was opening their minds to the world, and to other cultures, and allowed Lech Wojtczak to form from his collaborators the next generation of good scientists and future leaders. The list of the most important pupils of Professor Wojtczak is given in the article. Lech was also excellent in social contacts, and in creating a friendly atmosphere. Together with his wife Anna, they kept an open home, often inviting collaborators to parties that usually led to long scientific discussions. With the sudden death of Pofessor Lech Wojtczak Polish science suffered a great loss. This eminent researcher, the father of Polish bioenergetics, but also a warm and modest person, will be dearly missed.
    Źródło:
    Nauka; 2019, 4
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Continuous recording of intramitochondrial pH with fluorescent pH indicators: probes and limitations of the method
    Autorzy:
    Żółkiewska, Anna
    Czyż, Aneta
    Duszyński, Jerzy
    Wojtczak, Lech
    Powiązania:
    https://bibliotekanauki.pl/articles/1045482.pdf
    Data publikacji:
    1993
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1993, 40, 2; 241-250
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Projekt: Uniwersytet PAN
    On the project of the University of the Polish Academy of Sciences
    Autorzy:
    Duszyński, Jerzy
    Burczyński, Tadeusz
    Rowiński, Paweł M.
    Rychard, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1192859.pdf
    Data publikacji:
    2017-09-15
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    research university
    University of the Polish Academy of Sciences
    excellence in science
    uniwersytet badawczy
    Uniwersytet Polskiej Akademii Nauk
    doskonałość naukowa
    Opis:
    Instytuty Polskiej Akademii Nauk mają wśród polskich instytucji naukowych czołowy potencjał merytoryczny. W instytutach PAN w latach 2013-2016 powstało 19,7% prac afiliowanych w polskich instytucjach i umieszczonych w najbardziej prestiżowych pismach naukowych danych dziedzin (górne 10% z list pism danej dziedziny nauki uszeregowanych według rosnącego współczynnika wpływu, IF). Jest to najlepszy wynik wśród polskich instytucji akademickich. Kadra instytutów PAN zajmuje się nie tylko badaniami, ale też dydaktyką; 1607 osób (stan na 31 grudnia 2016) było na stacjonarnych studiach doktoranckich w Instytutach PAN. Stopień umiędzynarodowienia studiów w PAN (8%) jest największy wśród polskich uczelni. W związku z tym uzasadnione wydaje się powołanie Uniwersytetu PAN (UPAN), który mógłby stać się pierwszą w Polsce uczelnią badawczą. Planuje się, że docelowo kształciłoby się na nim 2,5 tys. osób, w przeważającej części studentek i studentów III stopnia. Taka liczba pozwoli na zagwarantowanie indywidualnej merytorycznej opieki każdemu studentowi, a także na wprowadzenie i przetestowanie nowatorskich programów dydaktycznych, właściwych erze Internetu i e-learningu, prowadzenia studiów online poprzez courser, studiów inter- i crossdyscyplinarnych. UPAN ma realne szanse stać się wizytówką polskiej nauki i szkolnictwa wyższego, gdyż otwarte, międzynarodowe wieloletnie programy konkursowe na pozycje: wizytujących profesorów, stażystów podoktorskich i doktorantów mogą podnieść umiędzynarodowienie zarówno kadry, jak i studentów UPAN do poziomu właściwego najlepszym uczelniom świata. Z uwagi na wielkość naszego budżetu nauki i szkolnictwa wyższego osiągnięcie takiego umiędzynarodowienia jest finansowo realne w najbliższym czasie tylko dla uczelni tak małej jak UPAN. Opisane działania będą projakościowe także dla samych instytutów PAN i istotnie podniosą ich poziom merytoryczny. Po kilku latach UPAN ma realne szanse na uplasowanie się w międzynarodowych rankingach na bardzo dobrych pozycjach, w pierwszej dwusetce, a nawet w pierwszej setce najlepszych światowych uczelni. Należy podkreślić, że warunkiem tego jest zapewnienie finansowania badań w instytutach PAN na co najmniej takim jak obecnie poziomie, uelastycznienie ich sieci, wytworzenie mechanizmów synergii pomiędzy instytutami (wspólny cel – UPAN) oraz wsparcie tego projektu długoletnim programem umiędzynarodowienia kadry i studentów.
    Among the scientific institutions in Poland, the institutes of the Polish Academy of Sciences possess top-ranking research potential. In the years 2013-2016, for instance, 19.7% of all research articles published in the most prestigious research journals for each particular field (the top 10% of the list of journals for each field, ranked by impact factor) by authors affiliated with Polish institutions came from the institutes of the Polish Academy of Sciences – this is far the best such percentage among all Polish academic institutions. The staff members at the PAS institutes are engaged not only in research, but also in teaching: as of 31 December 2016, there were 1607 individuals in regular PhD programs at the PAS institutes. Moreover, the degree of internationalization (8%) of these programs at the PAS institutes is the highest among all Polish higher-education institutions. These and other factors are seen as providing justification for the plan to pull together the potential of the PAS institutes in order to create a new higher-education institution, to be called the University of the Polish Academy of Sciences (UPAS), meant to become Poland’s first-ever research university. Plans call for UPAS to ultimately have a total of 2500 students studying in its programs, predominantly third-cycle (PhD-level) programs. Such a number will enable each student to be ensured individual supervision by top-notch researchers. It will also allow innovative teaching programs to be developed and tested in keeping with the new trends of the Internet era and e-learning, through online course offerings and through inter- and cross-disciplinary studies. Under this plan, UPAS stands a real chance of becoming a proud showpiece of Polish science and higher education: holding open, international competitions for various long-term positions as visiting professors, post-doc researchers, and PhD candidates will help further bolster the degree of internationalization among both the staff and students of UPAS, bringing it up to the level that characterizes the world’s best higher-education institutions. Given the size of Poland’s budget for science and higher education, attaining such a degree of internationalization in the near future will only be financially feasible for a university as small as UPAS. The above measures will also have a quality-boosting impact on the PAS institutes themselves, significantly improving their level. After several years, UPAS will stand a real chance of attaining very good standing in international rankings of the world’s higher education institutions, among the top 200 or even top 100 in the world. We should stress clearly: for this to happen, the funding for research at PAS institutes will need to be maintained on at least the same level as at present, the network of PAS institutes will need to be made more flexible, incorporating mechanisms generating significant synergy between the institutes (with UPAS as the common objective), and the project will need to be supported by a long-term program of internationalization of staff and students.
    Źródło:
    Nauka i Szkolnictwo Wyższe; 2017, 2, 50; 59-76
    1231-0298
    Pojawia się w:
    Nauka i Szkolnictwo Wyższe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research University, namely…
    Autorzy:
    Rowiński, Paweł M.
    Burczyński, Tadeusz
    Duszyński, Jerzy
    Rychard, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/703094.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    research university
    postgraduate university
    Polish Academy of Sciences
    University of the Polish Academy of Sciences
    Opis:
    With this paper we try to contribute to the debate on the nature of research intensive universities and the chances to create this type of institution in Poland. Research universities are presented as elite, flagship institutions for educating students mostly at the doctoral level and to produce the bulk of the research output. Examples of world-class research intensive universities from various countries are presented. It is shown that intensified competition among universities exists to prove their performance through global university league tables or ranking exercises and it is discussed whether Poland is at the stage to create at least one such institution playing important role in that competition. We argue that the establishment of a University of the Polish Academy of Sciences could be a solution. This University stands to become a unique research institution in Poland and one of very few establishments of its type in Central and Eastern Europe. The University will conduct scientific research and provide programs of the highest standard, exploiting the research and teaching potential of the PAS institutes as well as the competence and experience of members of the Academy's corporation. It is intended as a higher education institution with a decentralized organizational structure, based on the PAS research institutes. The University of the Polish Academy of Sciences will have a quality-boosting impact on the PAS institutes as well as initiate their consolidation and reorganization in the field of teaching. 
    Źródło:
    Nauka; 2017, 3
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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