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Tytuł:
Związki kompleksowe chromu(III), wanadu(IV) i kobaltu(II) jako nowe prekatalizatory polimeryzacji olefin
Chromium(III), vanadium(IV) and cobalt(II) complex compounds as new olefin polymerization precatalysts
Autorzy:
Drzeżdżon, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/171572.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
chrom
wanad
kobalt
związki kompleksowe
prekatalizatory
polimeryzacja
chromium
vanadium
cobalt
complex compounds
precatalysts
polymerization
Opis:
The olefin polymerization catalysts constitute a large group of various compounds. Metallocene complexes are the largest part of this group. However, due to the instability at industrial plastics temperatures and the decomposition of complexes after MAO (or MMAO) activation, they have been partly replaced by non-metallocene compounds. This article concerns the studies on new non- metallocene precatalysts for the olefin polymerization and oligomerization. The report focuses on the structure and the catalytic activities of the complexes of chromium(III), vanadium(IV) and cobalt(II) with the following ligands: dipicolinate, 2-pyridinecarboxylate, oxalate, oxydiacetate, iminodiacetate, 2,2’- bipyridine, 4,4’-dimethoxy-2,2’-bipyridine, 1,10-phenantroline. These complex compounds are highly active precatalysts for olefin polymerization and oligomerization. The complexes: [Cr(dipic)2][Cr(bipy)(dipic)H20]-2H20 and [Cr(dipic) 2]Hdmbipy2.5H20 deserve special attention because they are new type of the precatalysts i.e. organic salt type complexes composed both of organic cations and anions. These compounds are not only interesting because of their structure but also because of their high catalytic activity.
Źródło:
Wiadomości Chemiczne; 2020, 74, 5-6; 423-437
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie związków kompleksowych platyny, palladu i kobaltu w medycynie. Cz. 1
Application of coordination compounds of platinum, palladium and cobalt in medicine. Part 1
Autorzy:
Pawlak, Marta
Drzeżdżon, Joanna
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/1409835.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki kompleksowe platyny
związki kompleksowe palladu
związki kompleksowe kobaltu
leki przeciwnowotworowe
coordination compounds of platinum
coordination compounds of palladium
coordination compounds of cobalt
anticancer drugs
Opis:
The complex compounds containing metal ions are a group of compounds widely used in medicine. More and more metals are also being used to create cancer drugs or to help with other very serious diseases. Anticancer drugs are a particular use of complex compounds. Many thousands of platinum(II) compounds have been synthesized in cancer therapy, but only six of them have found use in the treatment of cancer. The most popular and the most commonly used compound is cisplatin, it has become the basis for the treatment of bladder, cervical, head, esophagus and many cancers occurring in children. The mechanism of action of platinum(II) and platinum(IV) compounds against cancer cells is to inhibit DNA replication, then RNA transcription and stop the G2 phase of the cell cycle and lead to programmed cell death or apoptosis. Coordination compounds containing more than one metal ion in their composition open new possibilities in the fight against cancer. Pt-DNA connections created by compounds containing at least two metal atoms are different from those formed by cisplatin. The basic dinuclear structure allows for great flexibility in forming DNA-DNA or DNA-protein bonds. The cobalt(III) complexes began to be used to image areas of hypoxia in cancer cells. It is believed, that cobalt(III) complexes undergo bioreduction, which leads to the release of the labile cobalt(II) complex and one or more bioactive ligands. Studies on nitro-Co(III) complexes containing acetylacetone and a nitrogen mustard ligand have shown that it is a particularly effective anti-cancer drug. Due to the fact that many people have cancer new effective anti-cancer drugs with low toxicity and no side effects are still being sought.
Źródło:
Wiadomości Chemiczne; 2020, 74, 11-12; 797-822
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie związków kompleksowych rutenu, złota, wanadu, chromu, bizmutu, technetu w medycynie. Cz. 2
Application of coordination compounds of ruthenium, gold, vanadium, chromium, bismuth, technetium in medicine. Part 2
Autorzy:
Pawlak, Marta
Drzeżdżon, Joanna
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/1409708.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki kompleksowe
radiofarmaceutyki
obrazowanie medyczne
właściwości hipoglikemiczne
complex compounds
radiopharmaceuticals
medical imaging
hypoglycemic properties
Opis:
In this review, the most important complex compounds of ruthenium, gold, vanadium, chromium, bismuth, technetium were selected, and then their most important applications were described in medicine. Ruthenium has been identified as a metal with potential medical use, useful in cancer chemotherapy. The possibility of using its chemical behavior by developing complexes activated for cytotoxic activity through a mechanism of reduction in tumor tissue was discovered. Among the new anti-cancer drugs based on complex compounds, gold compounds have gained a lot of interest. This is due to their strong inhibitory effect on the growth of cancer cells and the observation that many compounds inhibit the enzyme thioredoxin reductase. This enzyme is important for the proliferation of cancerous tissues, and its inhibition is associated with the release of anti-mitochondrial effects. Clinical tests have shown that vanadium compounds can be used as anti-diabetic drugs with low toxicity. However, the therapeutic concentration range is very narrow, just a few micromoles of the compound are enough to cause apoptosis, necrosis and inflammation of healthy cells. Chromium improves the glucose system in people with hypoglycemia or hyperglycemia. Vanadium compounds mainly used to create potential drugs are inorganic compounds such as vanadates(V), vanadyl cation(IV), vanadium oxide(V) and a number of compounds containing organic ligands. Among the metal complexes, chromium(III) picolinate has successfully become a nutrient used to prevent high blood sugar levels. One of the most commonly used bismuth(III) compounds is bismuth subsalicylate. It is one of the few bismuth compounds regularly used to treat various gastrointestinal complaints, including duodenal ulcers. 99mTc injected into the body, depending on its chemical form and molecular structure, concentrates in the examined organ and emits a quantum that allows imaging of the organ through flat scintigraphic or emission processes. The role of complex compounds in medical imaging is largely based on the creation of radiopharmaceuticals for early detection of diseases and cancer radiotherapy. Radiopharmaceuticals are radionuclide-containing drugs and are routinely used in nuclear medicine to diagnose or treat a variety of diseases.
Źródło:
Wiadomości Chemiczne; 2020, 74, 11-12; 823-851
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Struktura i właściwości fizykochemiczne polimerów koordynacyjnych oraz materiałów typu MOF kadmu(II) i cynku(II)
Structure and physicochemical properties of coordination polymers and MOF materials based on cadmium(II) and zinc(II)
Autorzy:
Pobłocki, Kacper
Drzeżdżon, Joanna
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/1413238.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
polimery koordynacyjne
sieci metaliczno-organiczne
związki kadmu(II)
związki cynku(II)
MOF
coordination polymer
metal organic framework
cadmium(II)
compounds
zinc(II) compounds
Opis:
In 1964, J.C. Bailat Jr. was one of the first scientists who use coordination polymers in his research. He established the rules of structure and the composition of compounds containing metal ions and organic ligands connected by coordination bonds to form layered or chain structures. He compared inorganic compounds belonging to polymeric species with organic polymers. The term Metal Organic Frameworks (MOF) was first used in the publication by О. M. Yaghia. Crystalline, microporous structures contain rigid organic ligands (used interchangeably: organic building blocks) that bind metal ions. This is called reticular synthesis. MOF surface area values usually range from 1000 to 10000 m2/g-1, thus exceeding the area values of traditional porous materials such as zeolites and carbons. Metal Organic Frameworks create porous three-dimensional structures, unlike coordination polymers. Inorganic minerals from the aluminosilicate group are used in the widespread heterogeneous catalysis and processes such as: adsorption and ion exchange, while compared to Metal Organic Frameworks, shows a lower potential than zeolites, moreover, the design of structures is less precise and rational due to the lack of shape, size and control functionalization of pores. To date, MOF are the most diverse and most numerous class of porous materials. All aspects have made them ideal structures for storing fuels such as hydrogen and methane. They are perfect for catalytic reactions and are good materials for capturing pollutants, e.g. CO2. The number of publications on coordination polymers (CP), Metal Organic Frameworks (MOF) or a group of hybrid compounds (organic-inorganic) increased tenfold at the turn of 2005, which proves the growing interest in this field by scientists around the world. MOF diversity in terms of structure, size, geometry, functionality and flexibility of MOF has led to the study of over 20,000 different MOF’s over the past decade. The search for new materials consists of combining molecular building blocks with the desired physicochemical properties. To produce a solid, porous material that can be used in the construction of a "molecular scaffold", rigid organic moieties, which are described in the literature as rods, must be combined with multi-core, inelastic inorganic clusters that act as joints (also called SBU secondary building units). By design, multi-core cluster nodes are able to impart thermodynamic stability through strong covalent bonds and mechanical stability due to coordination bonds that can stabilize the position of metals in the molecule. This property contrasts with those of the unstable single coordination polymers. The size and most importantly the chemical environment of the resulting voids are determined by the length and functions of the organic unit. Therefore, adjusting the appropriate properties of the material is made by appropriate selection of the starting materials. The isoretical method made it possible to use MOF structures with large pores (98 Á and low densities (0.13 g/cm3). This method involves changing the size and nature of Metal Organic Frameworks without changing the topology of their substrate. Thanks to this, it was possible to include large molecules such as vitamins (e.g. B12) or proteins (e.g. green fluorescence protein) into their structure and use the pores as reaction vessels. The thermal and chemical stability of many MOFs has made them amenable to functionalization by post-synthetic covalent organic complexes with metals. These properties make it possible to significantly improve gas storage in MOF structures and have led to their extensive research into the catalysis of organic reactions, activation of small molecules such as hydrogen, methane and water, gas separation, biomedical imaging and conductivity. Currently, methods of producing nanocrystals and MOF super crystals for their incorporation into specialized devices are being developed. Crystalline structures of MOF’s are formed by creating strong bonds between inorganic and organic units. Careful selection of MOF components produces crystals of giant porosity, high thermal and chemical stability. These features allow the interior of the MOF to be chemically altered to separate and store gases. The uniqueness of MOF materials is that they are the only solids to modify and increase the particle size without changing the substrate topology.
Źródło:
Wiadomości Chemiczne; 2021, 75, 7-8; 1041-1073
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Związki kompleksowe na bazie Gd(III), W(IV), Mn(II), Eu(III) i 99mTc wykorzystywane w diagnostyce medycznej
Complex compounds based on Gd(III), W(IV), Mn(II), Eu(III) and 99mTc used in medical diagnostics
Autorzy:
Pobłocki, Kacper
Drzeżdżon, Joanna
Jacewicz, Dagmara Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/2200431.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
obrazowanie medyczne
związki kompleksowe
magnetyczny rezonans jądrowy
tomografia emisyjna pojedynczego fotonu
rentgenografia
obrazowanie optyczne
medical imaging
complex compounds
magnetic resonance imaging
single-photon emission computed tomography
rentgenography
optical imaging
Opis:
Recently, hospitals have undergone major changes. Minimally invasive surgery is becoming more common, and numerous innovations are emerging, such as interventional radiology (IVR) and hybrid surgery. In order to keep pace with changes in this extremely dynamic field, scientist keep working on the development of imaging technology and the improvement of image display devices and new compounds acting as contrast agent (CA). In medicine, metals are used for diagnostic and therapeutic purposes. Inorganic elements are increasingly used as contrast agents in medical imaging due to their unique physicochemical properties. In this review, we would like to focus on the latest literature reports that contain information on Gd(III), W(IV), Mn(II), Eu(III) and 99mTc used in medical diagnostics.
Źródło:
Wiadomości Chemiczne; 2022, 76, 9-10; 803--823
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Związki wanadu i chromu jako potencjalne insulino-mime tyki wykorzystywane w leczeniu cukrzycy
Vanadium and chromium compounds as the potential insulin-mimetics used in the treatment of diabetes
Autorzy:
Drzeżdżon, Joanna
Malinowski, Jacek
Zych, Dominika
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/972299.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki wanadu
związki chromu
działanie insulino-naśladowcze
właściwości przeciwcukrzycowe
leczenie cukrzycy u ludzi
vanadium derivatives
chromium derivatives
insulin mimetic action
antidiabetic properties
human diabetic treatment
Opis:
The report focuses on the antidiabetic, also termed insulin-like, effect of various vanadium and chromium derivatives, proposed mechanisms of their activity, their use in in vivo and in vitro studies, as well as in diabetic patients, their toxicity and effectiveness in controlling clinical signs of diabetes. Studies indicate that compounds of vanadium and chromium is necessary for regulation of carbohydrate and lipid metabolism mainly due to increasing the number of insulin receptors and its activation by phosphorylation. Some authors believe that compounds of chromium(III) deficiency can lead to glucose intolerance and symptoms of type 2 diabetes. However, due to methodological limitations of many clinical studies, the statements of major diabetes associations concerning recommendation of various vanadium and chromium derivatives supplementation in individuals with diabetes and obesity still remains negative. Additional studies are urgently needed to elucidate the mechanism of action of chromium and vanadium compounds and its role in the prevention and control of diabetes.
Źródło:
Wiadomości Chemiczne; 2019, 73, 11-12; 753-775
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oznaczanie aktywności przeciwutleniającej metodami in-vitro
Determination of antioxidant activity with in-vitro methods
Autorzy:
Malinowski, Jacek
Drzeżdżon, Joanna
Chmurzyński, Lech
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/972307.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
aktywność przeciwutleniająca
metoda in vitro
antioxidant activity
in vitro methods
Opis:
In - vitro methods of determination of the antioxidant activity of complex compounds are very interesting and not fully investigated areas of knowledge from the borderline of chemistry and biology. Methods used for determination of the activity of antioxidant complex compounds are modified due to the conditions of the experiments in which they should be carried out, e.g. reactions at physiological pH. Civilization diseases, stress related to the fast pace of life and increasing requirements of our lives cause the formation of free radicals in our body, i.e. particles characterized by a high reactivity. The methods of determination of the antioxidant activity of complexes discussed in this work apply tests carried out in laboratory conditions - in - vitro.
Źródło:
Wiadomości Chemiczne; 2019, 73, 9-10; 523-542
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polimery z pamięcią kształtu i ich otrzymywanie
Shape-memory polymers and their preparation
Autorzy:
Andrzejewski, Kewin
Czyżów, Wiktor
Jacewicz, Dagmara
Drzeżdżon, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/2086740.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
polimery
synteza
katalizatory
zielona chemia
polymers
synthesis
catalysts
green chemistry
Opis:
SMP (shape-memory polymers) is an innovative class of programmable materials responsive to various stimuli. They are attracting increasing attention regarding possible new inventions, industrial use, and overall polymer research. After a brief introduction, this article examines the conventional shape-memory effect, methods of fabrication of shape memory polymers, and molecular and structural requirements for SMP to function. The shape memory behavior of such polymers is thoroughly presented, with the focus being on the thermo- and photo-induced SME. The uses in biomedical and industrial areas are also discussed.
Źródło:
Wiadomości Chemiczne; 2022, 76, 3-4; 183--205
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metody in-vivo badania właściwości antyoksydacyjnych związków kompleksowych
In-vivo methods for testing of the antioxidant properties of complex compounds
Autorzy:
Malinowski, Jacek
Drzeżdżon, Joanna
Chmurzyński, Lech
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/972295.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
właściwości przeciwutleniające
rodniki
metody in vivo
antioxidant properties
radicals
in vivo methods
Opis:
This article describes the in-vivo methods of studying the antioxidant properties of complex compounds. The reduced glutathione (GSH) method, which uses the reactivity of the reduced form of GSH with free radicals, is among the described methods. Further the in-vivo methods are based on the use of antioxidant enzymes such as glutathione peroxidase, glutathione S-transferase, superoxide dismutase, catalase. These types of enzymes occur naturally in the human body and they are responsible for the inactivation of free radicals, e. g. superoxide dismutase catalyzes the reaction of disproportionation of superoxide anion radical to water and oxygen. The next in-vivo methods described in this article use y-glutamyl transpeptidase and glutathione reductase, which are components of the antioxidant mechanism occurring in an organism. The last method described in this work relates to the lipid peroxidation, which is determined by the concentration of dimalonic aldehyde.
Źródło:
Wiadomości Chemiczne; 2019, 73, 7-8; 523-538
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oznaczanie aktywności przeciwutleniającej metodami in-vitro
Determination of antioxidant activity with in-vitro methods
Autorzy:
Malinowski, Jacek
Drzeżdżon, Joanna
Chmurzyński, Lech
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/972311.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
aktywność przeciwutleniająca
metoda in vitro
antioxidant activity
in vitro methods
Opis:
In - vitro methods of determination of the antioxidant activity of complex compounds are very interesting and not fully investigated areas of knowledge from the borderline of chemistry and biology. Methods used for determination of the activity of antioxidant complex compounds are modified due to the conditions of the experiments in which they should be carried out, e.g. reactions at physiological pH. Civilization diseases, stress related to the fast pace of life and increasing requirements of our lives cause the formation of free radicals in our body, i.e. particles characterized by a high reactivity. The methods of determination of the antioxidant activity of complexes discussed in this work apply tests carried out in laboratory conditions - in - vitro.
Źródło:
Wiadomości Chemiczne; 2019, 73, 9-10; 523-542
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie polikarboksylanowych związków kompleksowych w tworzeniu sieci metaloorganicznych typu MOF
Application of polycarboxylate comlexes in the formation of metal-organic frameworks
Autorzy:
Zych, Dominika
Drzeżdżon, Joanna
Jacewicz, Dagmara
Chmurzyński, Lech
Powiązania:
https://bibliotekanauki.pl/articles/171746.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
związki metaloorganiczne typu MOF
trójwymiarowa struktura
fizykochemiczne właściwości związków typu MOF
zastosowanie związków typu MOF
Metal–Organic Frameworks
MOF
three-dimensional framework structure
physicochemical properties of MOF
applications MOFs
Opis:
The first research on Coordination Polymers began at the beginning of the 20th century. Wider understanding of their structure has enabled the development of crystallography. Since then compounds, which belong to this group, have been the subject of broad-spectrum scientific research. A particular class of these compounds, known relatively recently, are Metal–Organic Frameworks (MOF). The MOF structure is based on negatively charged organic linkers, e.g. polycarboxylic anions connected to various metal cations or metal clusters. MOFs are mainly built up from metal cations: transition, alkaline earth, main groups of the periodic table, as well as rare earth metals. Moreover, organic ligands used in the construction of MOF materials should contain electron donors. A characteristic bond, that allows the formation of hybrids, through the interactions of nodes and bridges is the coordination bond. It allows to synthesize a three-dimensional framework structure. Modern synthesis leads to the generation of porous materials with a very large surface area of pores and unique properties. Considering their synthesis, crystalline structures and physicochemical properties of MOF, as well as broad MOFs applications including gas storage, separation, catalysts, luminescence, magnetism and others, it is reasonable to state that MOFs can be used in many areas, not only in science, but also in environmental protection and in industry, for example, energy industry, chemical and biochemical industry.
Źródło:
Wiadomości Chemiczne; 2019, 73, 5-6; 401-423
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości fizykochemiczne, biologiczne i aplikacyjne izocyjanków. Część 2., Zastosowanie w medycynie i materiałoznawstwie
Physicochemical, biological and application properties of isocyanides. Part 2., Medical and materials science applications
Autorzy:
Pawlak, Marta
Pobłocki, Kacper
Drzeżdżon, Joanna
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/2200417.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
isocyanides
medicine
pharmaceuticals
polymers
IBPs
izocyjanki
medycyna
farmaceutyki
polimery
Opis:
Isocyanides are compounds with a triple bond between a nitrogen atom and a carbon atom. Thanks to this structure, there is an electron lone pair on the carbon atom, which allows these compounds to participate in many reactions in organic chemistry. Due to their properties and the number of reactions in which they can participate, this group has been applied in medicine. Both natural and synthetic isocyanides have antifungal, antibacterial, antimalarial, antiviral and anticancer properties. The reactions involving them allow for a much simpler and faster synthesis of many pharmaceuticals. In addition, these compounds have application properties, making it possible to obtain polymers. Despite the polymerization of these compounds raising many objections, many polymeric materials based on isocyanides have found applications both in science and in everyday life.
Źródło:
Wiadomości Chemiczne; 2023, 77, 3-4; 239--256
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości fizykochemiczne, biologiczne i aplikacyjne izocyjanków. Część 1., Pochodzenie, otrzymywanie i reakcje chemiczne
Physicochemical, biological and application properties of isocyanides, Part 1., Origins, derivation and chemical reactions
Autorzy:
Pawlak, Marta
Pobłocki, Kacper
Drzeżdżon, Joanna
Jacewicz, Dagmara
Powiązania:
https://bibliotekanauki.pl/articles/2200424.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
isocyanides
isocyanates
isonitriles
electrophile nucleophile
reactions of isocyanides
izocyjanki
izocyjaniany
izonitryle
elektrofil
nukleofil
reakcje izocyjanków
Opis:
Isocyanides are the most unusual and unique group in organic chemistry. They possess an unusual valence structure and reactivity. Isocyanides are the only class of stable organic compounds with a formal divalent carbon, which allows them to be the subject of virtually all reactions in organic chemistry. It can be either an electrophile, a nucleophile, a caraben and a radical acceptor. We distinguish between naturally occurring and synthetically produced isocyanides. Both groups of isocyanides have become recently the subject of scientific interest.
Źródło:
Wiadomości Chemiczne; 2023, 77, 3-4; 215--237
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Katalizatory wykorzystywane w syntezie biodiesla
Catalysts used in biodiesel synthesis
Autorzy:
Pobłocki, Kacper
Walczak, Juliusz
Drzeżdżon, Joanna
Jacewicz, Dagmara Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/2200588.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
katalizator
biodiesel
synteza
biopaliwa
energia odnawialna
catalyst
synthesis
biofuels
renewable energy
Opis:
Rising prices of electricity, conventional fuels and heating require decisive steps in the further development of technologies based on renewable energy sources. These include geothermal- ; hydrothermal- ; aerothermal- ; and solar energy. Due to the fact that the petrochemical industry is one of the fastest growing branches of the economy, we would like to expand on the topic related to biofuels. Biodiesel is an alternative fuel similar to conventional diesel. It is usually made from animal fat, vegetable oil and waste cooking oil. Its biodegradability, nontoxicity and lack of sulfur and aroma content make it superior to conventional gasoline and diesel. During fuel consumption, it emits fewer air pollutants and greenhouse gases other than nitrogen oxides. In this literature review, we will discuss the latest trends in the world related to catalysts used in biodiesel synthesis.
Źródło:
Wiadomości Chemiczne; 2022, 76, 3-4; 129--144
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nowotwory kości : nowe możliwości terapeutyczne
Bone cancer : new therapeutic possibility
Autorzy:
Wyszkowska, Roksana
Drzeżdżon, Joanna
Musiał, Claudia
Górska-Ponikowska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/171964.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
kostniakomięsak
chrzęstniakomięsak
włókniakomięsak
tlenek azotu
2-metoksyestradiol
osteosarcoma
chondrosarcoma
fibrosarcoma
nitric oxide
2-methoxyestradiol
Opis:
Among bone tumours, Osteosarcoma (OS), Chondrosarcoma (CS) and Fibrosarcoma (FS) are highly metastatic with poor prognostic for survival. Standard procedures as surgery resection, radiotherapy and chemotherapy do not lead to full recovery or they do not affect metastasis [1-4]. Nowadays new molecular targets to cure cancer are during clinical trials. Clinical trials for OS are focused on using monoclonal antibody (dinutuximab) [5], immunotherapy (as using GM-CSF with influence on white blood cells) [6] or compounds acting as VEGFR inhibitor or PDGFR inhibitor - to reduce metastasis [7-9]. Clinical trials for CS are targeting the hedgehog pathway, focused on its inhibition [10], inhibition of IDH1/2 (common mutation in CS leading to hypermethylation) [11] or, as in OS treatment, inhibition of metastasis by acting on VEGFR [12]. Beyond new chemotherapy and chemotherapy correlated with radiotherapy [13] clinical trials for FS are targeting gene fusion NTRK acting through inhibition of tropomyosin kinase receptor [14]. This approach to treatment is a novelty on the global scale [15]. Nitric oxide (NO) has many biological functions, e.g.: acting as neurotransmitter, reduced aggregation of platelets, acting as EDRF or reducing the oxidative stress in tumours [16-18]. Due to the dual nature of NO [19] anti-proliferative, pro-apoptotic and cell cycle arrest effect of NO were observed [20-25]. It could be a new area to find novel anti-cancer compound. One of the molecular targets under the scientists consideration is the activation of nitric oxide synthase (NOS). Górska-Ponikowska et al. [26-28] focused on experiments on OS 143B cells with 2-methoxyestradiol (2-ME) treatment, potentially novel compound playing the role of n-NOS activator. The researchers reported influence of 2-ME on down-regulation of mitochondrial biogenesis via direct influence on n-NOS level in OS 143B cells. What is more, L-lactate was indicated as potential molecular marker of anticancer therapy of tumours with metastasis.
Źródło:
Wiadomości Chemiczne; 2019, 73, 11-12; 701-713
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
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