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Wyszukujesz frazę "Danilewicz, Olga" wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Distinct inhibitory efficiency of siRNAs and DNAzymes to β1 integrin subunit in blocking tumor growth
Autorzy:
Wiktorska, Magdalena
Sacewicz-Hofman, Izabela
Stasikowska-Kanicka, Olga
Danilewicz, Marian
Niewiarowska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1039612.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
adhesion
β1 integrins
invasiveness
tumor angiogenesis
tumor growth
Opis:
Receptors of the β1 integrin family are involved in many tumor-promoting activities. There are several approaches currently used to control integrin activity, and thus to potentially restrain tumor metastasis and angiogenesis. In this study, we compared inhibitory efficiencies of siRNA and DNAzymes against the β1 integrin subunit (DEβ1), in a mouse xenograft model. Both inhibitors were used under their most favorable conditions, in terms of concentrations, incubation time and lack of cytotoxic effects. Transfection of siRNAβ1 or DEβ1 remarkably inhibited the growth of both PC3 and HT29 colon cancer cells in vitro, and decreased their capability of initiating tumor formation in the mouse xenograft model. siRNAβ1 appeared to be slightly more efficient than DEβ1 when tested in vitro, however it was comparably less proficient in blocking the tumor growth in vivo. We conclude the DNAzyme, due to its greater resistance to degradation in extra- and intracellular compartments, to be a superior inhibitor of tumor growth in long lasting experiments in vivo when compared to siRNA, while the latter seems to be more efficient in blocking β1 expression during in vitro experiments using cell cultures.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 77-82
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
‘It is really interesting how that small robot impacts humans.’ the exploratory analysis of human attitudes toward the social robot vector in reddit and youtube comments
Autorzy:
Łupkowski, Paweł
Danilewicz, Olga
Ratajczyk, Dawid
Wasielewska, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/27314181.pdf
Data publikacji:
2022
Wydawca:
Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
Tematy:
robot
social robotics
human‐robot interaction
attitude towards robots
Opis:
We present the results of an exploratory analysis of hu‐ man attitudes toward the social robot Vector. The study was conducted on natural language data (2,635 com‐ ments) retrieved from Reddit and YouTube. We describe the tag‐set used and the (manual) annotation procedure. We present and compare attitude structures mined from Reddit and YouTube data. Two main findings are descri‐ bed and discussed: almost 20% of comments from both Reddit and YouTube consist of various manifestations of attitudes toward Vector (mainly attribution of autonomy and declaration of feelings toward Vector); Reddit and YouTube comments differ when it comes to revealed at‐ titude structure – the data source matters for attitudes studies.
Źródło:
Journal of Automation Mobile Robotics and Intelligent Systems; 2022, 16, 2; 3--10
1897-8649
2080-2145
Pojawia się w:
Journal of Automation Mobile Robotics and Intelligent Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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