- Tytuł:
- Selenocysteine in Trypanosoma evansi: Identification of the Genes selb, selc, seld, pstk, seltryp and the Selenophosphate Synthetase Protein
- Autorzy:
-
Tavares, Kaio Cesar Simiano
Dambrós, Maria Gabriela Casagrande
Antunes, André Saraiva Leão
Danziato, Pietro Martin
Stoco, Patricia Hermes
Schlindwein, Aline Daiane
Moreira, Renato Simões
Miletti, Luiz Claudio - Powiązania:
- https://bibliotekanauki.pl/articles/2041954.pdf
- Data publikacji:
- 2021-08-05
- Wydawca:
- Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
- Tematy:
-
Trypanosoma evansi
selenocysteine
selB
selC
selD
PSTK
seltTRYP - Opis:
- Selenoproteins have been described in all three domains of life and their function has been mainly associated with oxidative stress defense. Canonical elements required for selenoprotein production have been identified in members of the kinetoplastid group supporting the existence of a complete selenocysteine synthesis pathway in these organisms. Currently, nothing is known regarding the selenocysteine pathway in Trypanosoma evansi. In this study, we identified the expression of the elements selB, selC, selD, PSTK and selTRYP at the mRNA level in T. evansi. All translated proteins (selD, PSTK, selTRYP and selB) have the domains predicted and higher identity with Trypanosoma brucei. gambiense. The selenophosphate synthetase protein was localized in the cytoplasm. Our results support the existence of an active selenocysteine pathway in T. evansi.
- Źródło:
-
Acta Protozoologica; 2021, 60; 21-29
1689-0027 - Pojawia się w:
- Acta Protozoologica
- Dostawca treści:
- Biblioteka Nauki
Artykuł