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    Wyświetlanie 1-6 z 6
    Tytuł:
    POPULATION PHARMACOKINETICS OF 25-HYDROXY VITAMIN D IN NON-ELDERLY POSTMENOPAUSAL WOMEN
    Autorzy:
    DJOKOVIC, JELENA
    Tomic Lucic, Aleksandra
    MILOVANOVIC, OLIVERA
    BAZIC, DANIJELA
    VESELINOVIC, MIRJANA
    DJUKIC, ALEKSANDAR
    MATOVIC, SANDRA
    ZIVKOVIC ZARIC, RADICA
    VELICKOVIC RADOVANOVIC, RADMILA
    JANKOVIC, SLOBODAN
    MILOVANOVIC, JASMINA
    Powiązania:
    https://bibliotekanauki.pl/articles/895436.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    women
    postmenopausal women
    25-hydroxy vitamin D
    Population pharmacokinetics
    NONMEM
    Opis:
    Introduction/aim: The aims of this study were to develop a population pharmacokinetic (PPK) model for the clearance of 25-hydroxy vitamin D in non-elderly postmenopausal women and to identify the factors which have a significant influence on its clearance. Methods: The study population consisted of postmenopausal women who had been referred for evaluation of bone mineral density (BMD) by DEXA (dual-energy x-ray absorptiometry) scanner. The population pharmacokinetics modelling was conducted using the ADVAN 1 subroutine from a non-linear mixed effects (NONMEM) program, and thirty-two covariates were assessed. Results: A total of 75 serum concentrations were obtained from the same number of postmenopausal women and used for PPK analysis. The mean values of the participants’ age was 57.92±3.93 years and their body weight was 69.76±11.49kg. A wide range of 25-hydroxy vitamin D concentrations was observed (from 3.41 to 61.92ng/mL) with a mean value of 26.19±10.95ng/mL. A total of 32 covariates were examined and preliminary results suggested the influence of six covariates on 25-hydroxy vitamin D clearance. In the final PPK model however, only one covariate was shown to have a significant impact on the clearance value – the mean daily dietary intake dose of vitamin D (DD). Conclusions: These findings offer a preliminary basis on which to determine the level of vitamin D supplementation required by individual postmenopausal women. It could prove particularly important in achieving optimal serum levels of vitamin D in this vulnerable population.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 129-136
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Window Roller Blinds on Energy Consumption in Residential Buildings in Serbia
    Autorzy:
    Djoković, Jelena M.
    Nikolić, Ružica R.
    Bokůvka, Otakar
    Pastorková, Jana
    Powiązania:
    https://bibliotekanauki.pl/articles/27323565.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Menedżerów Jakości i Produkcji
    Tematy:
    exterior window blinds
    heat load
    cooling load
    lighting
    energy efficiency
    rolety zewnętrzne
    obciążenie cieplne
    obciążenie chłodnicze
    oświetlenie
    efektywność energetyczna
    Opis:
    Roller blinds are devices that are retracted and wrapped in a box above the window opening and are used to protect against the solar radiation. Those are the well-known devices with distinct advantages over the fixed external dimming elements. The influence of external blinds on the internal thermal environment in climatic conditions in the Republic of Serbia, the city of Kragujevac, was considered in this research. An external blind was installed in the test room and its influence on the internal temperature was compared with the internal temperature of the room without the blind. Real-time monitoring was carried out in February and August 2023. The results presented in this paper show that the blind reduces the temperature in summer by 3.57ºC and increases it in winter by 1.76ºC. The cooling load can be reduced by about 20%, and the heat load by about 15%.
    Źródło:
    System Safety : Human - Technical Facility - Environment; 2023, 5, 1; 75-82
    2657-5450
    Pojawia się w:
    System Safety : Human - Technical Facility - Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of work-related injuries in mining industry in Serbia
    Autorzy:
    Ivaz, Jelena
    Petrović, Dejan
    Nikolić, Ružica R.
    Djoković, Jelena M.
    Powiązania:
    https://bibliotekanauki.pl/articles/88464.pdf
    Data publikacji:
    2020
    Wydawca:
    Stowarzyszenie Menedżerów Jakości i Produkcji
    Tematy:
    mining industry
    safety
    work-related injuries
    absence from work due to injury
    przemysł wydobywczy
    bezpieczeństwo
    wypadek przy pracy
    bezpieczeństwo i higiena pracy
    absencja powypadkowa
    Opis:
    The mining industry in Serbia has an important place in the country's economic development. Bearing in mind that the number of injuries that occur in the mining industry is unacceptably high, occupational safety and health is a challenge that existing and future mines will have to deal with. Studying injuries in mining, it was noticed that injuries requiring an absence from work for more than three days (especially fatal ones) are diametrically different in relation to the cause and manner of events related to injuries for which an absence from work is not necessary. In this research, authors focused on injuries that were characterized as ones requiring an absence from work. The statistical analysis of work-related injuries in mining is presented, as well as analysis of the direct causes of injuries, which are described as unsafe conduct of employees, unsafe conduct of company's management and/or unsafe working environment. In relation to classification of causes of injuries, a recommendation on what needs to be changed in order to remedy this situation in Serbia is given.
    Źródło:
    System Safety : Human - Technical Facility - Environment; 2020, 2, 1; 158-165
    2657-5450
    Pojawia się w:
    System Safety : Human - Technical Facility - Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prediction of the work-related injuries based on neural networks
    Autorzy:
    Ivaz, Jelena
    Nikolić, Ružica R.
    Petrović, Dejan
    Djoković, Jelena M.
    Hadzima, Branislav
    Powiązania:
    https://bibliotekanauki.pl/articles/1831305.pdf
    Data publikacji:
    2021
    Wydawca:
    Stowarzyszenie Menedżerów Jakości i Produkcji
    Tematy:
    mining industry
    safety
    work-related injuries
    artificial neural networks
    przemysł górniczy
    bezpieczeństwo
    wypadek przy pracy
    sztuczne sieci neuronowe
    Opis:
    Artificial neural networks (ANN) are a powerful tool in the decision-making process, especially in solving the complex problems with a large number of input data. The possibility to predict the work-related injuries in the underground coal mines, based on application of the neural networks, is analyzed in this work. the input data for the network were obtained based on a survey of 1300 respondents. After analyzing the input data influence on the network output, 14 most influential inputs were selected, with help of which the network correctly predicted whether the worker would suffer the work-related injury or not, with 80% precision. The two models were developed, based on the multilayer perceptron (MLP) and radial basis function (RBF) networks. The two models' results were compared to each other. The sensitivity analysis was used to select the most influential parameters, like mine, age of miners, as well as their work experience. The parameters were further analyzed by use of the descriptive statistics. The selected parameters are direct indicators of problems that can cause injuries. The obtained results point to the fact that the work-related injuries can be successfully predicted by application of the artificial neural networks. The proposed models' importance is reflected in the clear indicators for enforcing the stricter occupational safety and organizational measures in order to reduce the number of work-related injuries in underground mines.
    Źródło:
    System Safety : Human - Technical Facility - Environment; 2021, 3, 1; 19-37
    2657-5450
    Pojawia się w:
    System Safety : Human - Technical Facility - Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Calculation of the thermal dynamic performance of the residential buildings walls
    Autorzy:
    Kalinović, Saša M.
    Djoković, Jelena M.
    Nikolić, Ružica R.
    Hadzima, Branislav
    Powiązania:
    https://bibliotekanauki.pl/articles/104140.pdf
    Data publikacji:
    2019
    Wydawca:
    Stowarzyszenie Menedżerów Jakości i Produkcji
    Tematy:
    wall's specific mass
    heat conduction coefficient
    periodical heat transfer
    reduction factor
    thermal inertia
    ściany
    współczynnik przewodzenia ciepła
    okresowe przekazywanie ciepła
    współczynnik redukcji
    bezwładność cieplna
    Opis:
    Calculation of the thermal dynamic properties of the multi-layer wall isolation of residential buildings is presented in this paper. Taking into account that the final objective is to create a building with the highest energy efficiency ratio, i.e. with the lowest energy consumption, both for heating and cooling, it is necessary to realize the good thermal characteristics of the multi-layer wall. To obtain the optimal solution for the wall's structure, various wall structures with different thicknesses of the individual layers, were analyzed. Based on results, presented in this paper, one can conclude that for walls with the same total thickness, but various thicknesses of the individual layers, that constitute the complete wall structure, the differences appear in the delay of the change of the walls outside temperature. In that way, by varying those individual layers' thicknesses, one can obtain the optimal solution for the wall structure with the highest savings of energy.
    Źródło:
    Quality Production Improvement - QPI; 2019, 1, 1; 212-221
    2657-8603
    Pojawia się w:
    Quality Production Improvement - QPI
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Thermal fracture characteristics of an interface crack subjected to temperature variations
    Autorzy:
    Kalinović, Saša M.
    Djoković, Jelena M.
    Nikolić, Ružica R.
    Hadzima, Branislav
    Powiązania:
    https://bibliotekanauki.pl/articles/1839517.pdf
    Data publikacji:
    2020
    Wydawca:
    Stowarzyszenie Menedżerów Jakości i Produkcji
    Tematy:
    interface crack
    two-layered sample
    temperature variation
    fracture properties
    LEFM concept
    pęknięcia
    próba dwuwarstwowa
    wahania temperatury
    właściwości pękania
    koncepcja LEFM
    Opis:
    Thermal fracture characteristics - the thermal energy release rate and thermal stress intensity factor of a semi-infinite crack at an interface between the two elastic isotropic materials, subjected to the temperature variations, are considered in this paper. Those characteristics are determined based on application of the linear elastic fracture mechanics (LEFM) concept. Expressions for obtained theoretical solutions are compared to solutions from literature and they are found to be more concise. Influence of the materials change on these two thermal fracture properties were observed, as well as the influence of the thickness ratio of the two layers constituting the interface.
    Źródło:
    Production Engineering Archives; 2020, 26, 2; 54-59
    2353-5156
    2353-7779
    Pojawia się w:
    Production Engineering Archives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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