Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Długosz, Jacek" wg kryterium: Autor

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-2 z 2
    Tytuł:
    Effect of calcinated halloysite on structure and properties of rigid poly(vinyl chloride) composites
    Autorzy:
    Wieczorek, Martina
    Tomaszewska, Jolanta
    Bajda, Tomasz
    Długosz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/2202880.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    polymer composites
    mechanical properties
    thermal properties
    halloysite
    poly(vinyl chloride)
    kompozyty polimerowe
    właściwości mechaniczne
    właściwości termiczne
    haloizyt
    chlorek winylu
    Opis:
    Halloysite is a filler which may be used to produce composites with thermoplastic polymer matrix. This work summarized the results of investigations of processing, structural, mechanical, and thermal properties of the composites with poly(vinyl chloride) (PVC) matrix and raw halloysite (HA) as well as its calcined product (KHA). The effectiveness of calcination was confirmed with X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption method. The PVC composites with HA as well as KHA were processed in the molten state in the Brabender mixer chamber. The reduction of gelation time and simultaneous increase in maximum torque with filler content were found based on the results of plastographometric analysis. SEM images of PVC/halloysite composites showed a homogeneous distribution of the filler in the polymer matrix. The introduction of halloysite leads to a slight increase in Young’s modulus and tensile strength compared to neat PVC, where the increase of both parameters is greater when KHA is used. The incorporation of 1% KHA led to an increase in impact strength, an effect which may be attributed to toughening of the polymer. A slight improvement of the Vicat softening temperature of 2.7 degrees C for PVC/HA and heat deflection temperature of 2.4 C for PVC/KHA was also ascertained for PVC modified with 10 wt% of filler.
    Źródło:
    Chemical and Process Engineering; 2022, 43, 3; 383--404
    0208-6425
    2300-1925
    Pojawia się w:
    Chemical and Process Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anticancer activity of new molecular hybrids combining 1,4-naphthalenedione motif with phosphonic acid moiety in hepatocellular carcinoma HepG2 cells
    Autorzy:
    Długosz, Angelika
    Gach, Katarzyna
    Szymański, Jacek
    Modranka, Jakub
    Janecki, Tomasz
    Janecka, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038683.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MTT test
    apoptosis
    real-time PCR
    flow cytometry
    Opis:
    Structural motifs found in naturally occurring compounds are frequently used by researchers to develop novel synthetic drug candidates. Some of these new agents are hybrid molecules which are designed through a concept of combining more than one functional element. In this report, anticancer activity of new synthetic molecular hybrids, substituted 3-diethoxyphosphorylnaphtho[2,3-b]furan-4,9-diones and 3-diethoxyphosphorylbenzo[f]indole-4,9-diones, which integrate natural 1,4-naphtalenedione scaffold, present in several anticancer agents, with pharmacophoric phosphonate moiety, were tested against hepatocellular cell line HepG2. Cytotoxicity was examined using MTT assay. Two most potent compounds, furandione 8a and benzoindoldione 12a, which reduced the number of viable HepG2 cells with the IC50 values of 4.13 µM and 5.9 µM, respectively, were selected for further research. These compounds decreased the mRNA expression levels of several genes: Bcl-2, angiogenic vascular endothelial growth factor (VEGF), c-Fos, caspase-8 and increased the expression of Bax, caspase-3 and -9, c-Jun, p21, p53, as determined by quantitative real-time PCR. The ability of these compounds to induce apoptosis and DNA damage was studied by flow cytometry. The obtained data showed that the new compounds inhibited cell viability by increasing apoptosis and decreasing angiogenesis. Compound 8a was a much stronger apoptosis inducer as compared with 12a and strongly activated the intrinsic pathway of apoptosis, associated with the loss of mitochondrial membrane potential and changes in Bax/Bcl-2 ratio. These findings show that the synthetic hybrids combining 1,4-naphthalenedione system and phosphonic acid moiety display potential to be further explored in the development of new anticancer agents.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 41-48
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies