- Tytuł:
- Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates.
- Autorzy:
-
Cieślak, Jacek
Sobkowski, Michał
Jankowska, Jadwiga
Wenska, Małgorzata
Szymczak, Marzena
Imiołczyk, Barbara
Zagórowska, Izabela
Shugar, David
Stawiński, Jacek
Kraszewski, Adam - Powiązania:
- https://bibliotekanauki.pl/articles/1044136.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
H-phosphono(di)thioates
aryl nucleoside H-phosphonates
nucleoside 2',3'-cyclic phosphate analogues
H-phosphonamidates
nucleophilic catalysis - Opis:
- This review presents a brief account of the chemistry and mechanistic aspects of aryl H-phosphonates, and selected applications of this class of compounds as intermediates in the synthesis of a wide range of biologically important analogues of nucleoside phosphates, and oligonucleotides, in which the phosphate moieties are replaced by other structurally related groups. The aryl nucleoside H-phosphonates, compounds of controlled reactivity, have proven to be more versatile and superior to various mixed anhydrides as synthetic intermediates, particularly for preparation of nucleotide analogues bearing P-N or P-S bonds in various configurational arrangements at the phosphate moiety.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 2; 429-442
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł