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Wyszukujesz frazę "Chwedorowicz, Roman" wg kryterium: Autor


Wyświetlanie 1-4 z 4
Tytuł:
Neurophysiological maturation in adolescence - vulnerability and counteracting addiction to alcohol
Autorzy:
Chwedorowicz, Roman
Skarżyński, Henryk
Pucek, Weronika
Powiązania:
https://bibliotekanauki.pl/articles/989898.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
adolescence
neurophysiological maturation
alcohol vulnerability
alcohol addiction
genetic markers
event-related potential (erp)
p3 amplitude
event-related oscillation (ero
electroencephalography (eeg)
Opis:
The results of contemporary studies confirm the formation of two neural networks in the brain during the period of adolescence. The first is defined as emotional, located in the limbic system, develops earlier, quicker, and more intensively than the second one in the prefrontal cortex, called the judgement network, which fulfils the role of control and inhibition of emotional reactions. The domination of the emotional network in adolescence is manifested by hyperactivity of the limbic system, accompanied by intensified undertaking of courageous, reckless, risky, or even sometimes dangerous actions, so very characteristic in the maturation. The aim of the article is to present the state of the art in the field of latest achievements in experimental neurophysiology related to the maturation of the structural end functional processes in adolescents, and to alcohol vulnerability. Alcohol effect initiation starts in early adolescence, and therefore is connected with alcohol abuse and addiction in adulthood, which confirms the necessity for provision of an early prophylactic protection for juveniles, even before entering the phase of early adolescence. Some electrophysiological characteristics, such as low P3 amplitude of the Event-Related Potential (ERP) and Event-Related Oscillations (EROs), are manifested by their high risk offspring, and are considered to be biological markers (endophenotypes) of a predisposition to develop alcohol use disorders. Electroencephalographic oscillations induced within the range of the theta and delta waves (Event-Related Oscillation- ERO), considered as endophenotypes and markers of increased vulnerability for addiction, present three groups of genes and three types of neurotransmitters, with gamma aminobutyric acid, acetylcholine and glutamate as neurotransmitters in the central nervous system. A new research approach consisting in the application of electroencephalographic methods and techniques in developmental and genetic studies of the conditioning of varied vulnerability, and especially increased preferences for alcohol tasting and abuse in adolescence, provide unique possibilities for comprehensive and deepened studies which may contribute to the prevention of alcohol addiction, the genesis of which, to a great extent, is related with the effect of causative environmental and genetic factors during adolescent development.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE EEG EXAMINATION, TOGETHER WITH P300 POTENTIAL AS A METHOD FOR CAUSATIVE DIFFERENTIATION IN PATIENTS WITH A GENETIC AND ENVIRONMENTAL CONDITIONING TO ALCOHOL ADDICTION
Autorzy:
Chwedorowicz, Roman
Raszewski, Grzegorz
Studziński, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/2137788.pdf
Data publikacji:
2017-12-23
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
Alcoholism
Evoked potentials P300
Endophenotype
Opis:
The electrophysiological characteristics of alcoholics, such as the P300 amplitude of the Event-Related Potential (ERP), are related to high risk in their offspring, and are considered to be biological endophenotypes of a predisposition to develop alcohol use disorders. Contemporary knowledge justifies early diagnoses of the alcohol risk degree among adolescents, or even children, including their families, involving an examination of the P300 potential as an endophenotype, prior to achievement of an age of alcohol initiation. The results of such research approaches may be of importance not only cognitively, but also of prophylactically, in the early recognition of increased susceptibility to alcohol. The simplicity and non-invasiveness, and the exceptionally low costs of the methods described, should obtain for the present as well as in the future, a wider examination, one potentially even mass scope of in character and usefulness. The knowledge of such an endophenotype and genetically-related susceptibility, in the individual, family, and social dimension and transmission, and in the rearing of children and adolescents, could protect – not just individuals – but many from entering into the route of addiction, which is most frequently the effect of acting unaware and with negative life consequences, both generational and transgenerational for generations to come.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 457-465
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The P300 event-related brain potential, relationship with functional, familial and chronic subtypes of alcohol dependence
Autorzy:
Chwedorowicz, Roman
Skarżyński, Henryk
Kapka-Skrzypczak, Lucyna
Pucek, Weronika
Studziński, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/972388.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcoholics
endophenotypes
evoked potentials
National Institute on Alcohol Abuse and Alcoholism (U. S.)
Opis:
The results of contemporary studies confirm that the electrophysiological characteristics of alcoholics, such as low P300 amplitude of the Event-Related Potential (ERP), are related with high risk in their offspring, and are considered to be biological endophenotypes of predisposition to develop alcohol use disorders. The purpose of this study was to evaluate the differences in the theta (4–7 Hz) ERP occurring in the P300 response in the resting EEG of alcoholics in comparison to normal age- and gender-matched control subjects. The study included individuals of Polish ancestry with three generations (parents, siblings, spouses, marrying into the family, and children) from families with a positive diagnosis of alcohol dependence. Next, the group of alcoholics was subdivided into five distinct groups, according to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The control group consisted of 25 unaffected individuals from families who were screened and assessed to be negative for a diagnosis of alcohol dependence. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in patients with alcohol addiction. The amplitude and latency of auditory P300 response was recorded in the frontal, central, occipital and temporal regions, in control and alcohol dependent individuals. The amplitude of auditory P300 response in the central areas of the brain was lower in alcoholics in all studied groups, compared to the control subjects, except for the young adult subtype. No statistical difference in the amplitude of P300 potential in the studied brain regions was observed between the young adult subtype, and the control group. Similar P300 amplitude values in the young adult subtype and in the controls, and different values in the remaining alcoholics in the study, allow the differentiation into two subtypes of young alcoholics, based on the P300 amplitude as the biological endophenotype, and provide the background related with causative environmental and genetic factors in alcohol addiction.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 82-86
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Event-related potentials (ERP) and SGIP1 gene polymorphisms in alcoholics: relation to family history of alcoholism and drug usage
Autorzy:
Chwedorowicz, Roman
Raszewski, Grzegorz
Kapka-Skrzypczak, Lucyna
Sawicki, Krzysztof
Studziński, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/991182.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcohol dependence
event-related potentials
resting theta eeg power
sgip1 snps
Opis:
Objective. The electrophysiological characteristics may serve as valuable biomarkers for the genetic vulnerability underlying alcoholism. The purpose of this study was to evaluate the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and the theta ERP quantitative traits. Method. The theta band (4–7 Hz) visual ERP occurring in the P300 response in the resting EEG were examined to explore the electrophysiological effects of alcohol on the brain in five regions: frontal, central, parietal, temporal and occipital in patients with alcohol addiction. In addition, we tested the potential associations between single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and ERP quantitative traits. Results. We found that the amplitude of the auditory P300 response differed considerably among groups of alcoholics in the frontal, central and temporal areas of the brain and it was lower in the studied brain regions in alcoholics in comparison to non-alcoholics. However, among subjects in the young adult group (GR-1) there was no statistical difference in amplitude of P300 response with control subjects in all studied brain regions in comparison with non-alcoholics. Moreover, we revealed that SNP rs10889635 had a significant effect on P300 amplitude in the central and temporal regions. The reduced P300 amplitude was in AA carriers in comparison to both carriers of GG and GA alleles. Conclusion. The present study demonstrated a possible association of target P300 evoked theta and of alcohol dependence with SNPs from the gene SGIP1 in the region of rs10889635, but further studies are required.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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