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    Wyświetlanie 1-7 z 7
    Tytuł:
    Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
    Autorzy:
    Li, Xiao-Xing
    Zhao, Lang
    Chang, Ying
    Liu, Bao-Shan
    Xu, Feng
    Zhang, Cheng
    Ji, Xiao-Ping
    Chen, Yu-Guo
    Li, Chuan-Bao
    Powiązania:
    https://bibliotekanauki.pl/articles/1038380.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    obese
    inflammation
    remodeling
    ezetimibe
    IL-6
    Opis:
    Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 465-470
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
    Autorzy:
    Li, Chuan-Bao
    Li, Xiao-Xing
    Chen, Yu-Guo
    Gao, Hai-Qing
    Bao, Cheng-Mei
    Liu, Xiang-Qun
    Bu, Pei-Li
    Zhang, Juan
    Zhang, Yun
    Ji, Xiao-Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1039743.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Rat
    Metabolism
    Myocardium
    Phosphorylation
    Insulin resistance
    Opis:
    Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 249-254
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A method for designing the longitudinal position of a porthole in a manned submersible based on the back muscle fatigue characteristics
    Autorzy:
    Zhu, Mengya
    Chen, Dengkai
    Fan, Yu
    Guo, Jiayan
    Powiązania:
    https://bibliotekanauki.pl/articles/2094205.pdf
    Data publikacji:
    2021-12-13
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    surface electromyography
    muscle fatigue
    work efficiency
    manned submersible
    porthole position design
    oceanauts
    Opis:
    ObjectivesThe proper porthole angle contributes to relieving the operation fatigue and improving the efficiency of oceanauts. In this study, the authors explored the effect of 3 different porthole longitudinal positions on the oceanauts’ back muscles using surface electromyography (sEMG) analysis, and the characteristics of the perceived body comfort was obtained.Material and MethodsOverall, 40 healthy participants were recruited to perform tasks in a simulated cabin environment. Electromyographic (EMG) signals were recorded from the trapezius medius, lower trapezius, and erector spinal muscles for porthole angles of –5°, –15°, and +15°, relative to the horizontal line of sight during a 21-minute experiment. The subject comfort scores were collected at 7, 14 and 21 min. The integrated electromyogram (iEMG) and the root mean square (RMS) of EMG signals, as well as the mean power frequency (MPF), and the mean frequency (MF) were calculated.ResultsThe subjective scores of the +15° porthole at each stage of work are higher than those of the –15° and –5° portholes. The results of iEMG, RMS, MF and MPF all indicated that the +15° porthole design was more conducive to lowering the rate of muscle fatigue, while the –5° and –15° portholes increased the muscle fatigue rate and led to greater fatigue. It was found that the lower trapezius was more prone to fatigue than the trapezius medius and erector spinal muscles. The height, weight and body mass index of the participants were found to negatively correlate with muscles at the +15° porthole, which is highly consistent with the actual situation.ConclusionsThe findings suggested that the +15° position was optimal for delaying the muscle fatigue of the participants and for improving the work efficiency of oceanauts.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 6; 701-721
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A practical approach to the assessment of waterjet propulsion performance: the case of a waterjet-propelled trimaran
    Autorzy:
    Zhang, Lei
    Zhang, Jia-ning
    Shang, Yu-chen
    Dong, Guo-xiang
    Chen, Wei-min
    Powiązania:
    https://bibliotekanauki.pl/articles/963425.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
    Tematy:
    waterjet propulsion thrust
    pressure jump method
    boundary element method
    trimaran
    negative thrust deduction
    Opis:
    To obtain a reasonable evaluation of the performance of waterjet propulsion at the design stage, a semi-theoretical and semi-empirical method is used to calculate the fundamental parameters of waterjet propulsion performance using an iterative approach. To calculate the ship’s resistance, a boundary element method based on three-dimensional potential flow theory is used to solve the wave-making resistance, and an empirical approach is used to evaluate the viscous resistance. Finally, the velocity and pressure of the capture area of the waterjet propulsion control volume are solved based on turbulent boundary layer theory. The iteration equation is established based on the waterjet-hull force-balance equation, and the change in the ship’s attitude and the local loss of the intake duct are considered. The performance parameters of waterjet propulsion, such as resistance, waterjet thrust, thrust deduction, and the physical quantity of the control volume, are solved by iteration. In addition, a PID-controlled free-running ship model is simulated using the RANS CFD method as a comparison. We apply the proposed approach and the RANS CFD method to a waterjetpropelled trimaran model, and the simulation process and the results are presented and discussed. Although there are some differences between the two methods in terms of the local pressure distribution and thrust deduction, the relative error in the evaluation results for the waterjet propulsion performance is generally reasonable and acceptable. This indicates that the present method can be used at the early stages of ship design without partial information about the waterjet propulsion system, and especially in the absence of a physical model of the pump.
    Źródło:
    Polish Maritime Research; 2019, 4; 27-38
    1233-2585
    Pojawia się w:
    Polish Maritime Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    On choosability of complete multipartite graphs $K_{4,3*t,2*(k-2t-2),1*(t+1)}$
    Autorzy:
    Zheng, Guo-Ping
    Shen, Yu-Fa
    Chen, Zuo-Li
    Lv, Jin-Feng
    Powiązania:
    https://bibliotekanauki.pl/articles/744583.pdf
    Data publikacji:
    2010
    Wydawca:
    Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
    Tematy:
    list coloring
    complete multipartite graphs
    chromatic-choosable graphs
    Ohba's conjecture
    Opis:
    A graph G is said to be chromatic-choosable if ch(G) = χ(G). Ohba has conjectured that every graph G with 2χ(G)+1 or fewer vertices is chromatic-choosable. It is clear that Ohba's conjecture is true if and only if it is true for complete multipartite graphs. In this paper we show that Ohba's conjecture is true for complete multipartite graphs $K_{4,3*t,2*(k-2t-2),1*(t+1)}$ for all integers t ≥ 1 and k ≥ 2t+2, that is, $ch(K_{4,3*t,2*(k-2t-2),1*(t+1)}) = k$, which extends the results $ch(K_{4,3,2*(k-4),1*2}) = k$ given by Shen et al. (Discrete Math. 308 (2008) 136-143), and $ch(K_{4,3*2,2*(k-6),1*3}) = k$ given by He et al. (Discrete Math. 308 (2008) 5871-5877).
    Źródło:
    Discussiones Mathematicae Graph Theory; 2010, 30, 2; 237-244
    2083-5892
    Pojawia się w:
    Discussiones Mathematicae Graph Theory
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An early warning method for a slope based on the increment ratio of anchor cable internal force
    Autorzy:
    Feng, Jianhua
    Chen, Jiaxin
    Li, Jian
    Zhang, Yu
    Guo, Jianhua
    Qiu, Hongyong
    Powiązania:
    https://bibliotekanauki.pl/articles/2203436.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Prestressed anchor cables are active reinforcement to improve slope stability. However, the anchoring is not a permanent guarantee of stability, and the slope retains a potential risk of instability. From the perspective of the internal force of anchor cables, a new early warning method for the safety of the slope is provided, and a slope analysis model is established. With the increase in the strength reduction factor, the internal force increment curves of anchor cables under different prestresses are obtained. The point corresponding to strength reduction factors λ1 and λ2 represents a warning point. Key conclusions are drawn as follows: (1) The internal force of an anchor cable can be used to judge the stability of the slope strengthened by a prestressed anchor cable. (2) A warning index based on the internal force increment ratio of anchor cables is established. (3) The internal force increment ratio of anchor cables eliminates the influence of the initial prestress and is convenient for engineering applications.
    Źródło:
    Archives of Civil Engineering; 2023, 69, 1; 553--569
    1230-2945
    Pojawia się w:
    Archives of Civil Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats
    Autorzy:
    Zou, Liu
    Xiong, Shujuan
    Deng, Xiangping
    Liu, Juan
    Xiong, Runde
    Wang, Zhe
    Cao, Xuan
    Chen, Yanming
    Guo, Yu
    Tang, Guotao
    Powiązania:
    https://bibliotekanauki.pl/articles/895637.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    scutellarin
    TPGS
    polymeric micelles
    antithrombotic drugs
    Opis:
    To improve the clinical effect of scutellarin by extending the action time in vivo, scutellarin loaded polymeric micelles were developed by D-alpha tocopherol polyethylene glycol 1000 succinate (Scu/TPGS). Scu/TPGS were prepared using film solvent diffusion methods and characterized on the basis of their particle size, zeta potential, and drug encapsulation efficiency. Dynamic dialysis was used to study the release behavior of the polymeric micelles in vitro. Its pharmacokinetic characteristics and antithrombotic efficacy were studied by intravenous injection in rats. The results showed that Scu/TPGS were spherical, 20.09±2.62 nm in size and a slow release in vitro. The pharmacokinetic parameter T1/2 of Scu/TPGS was 762.12±46.56 min compared with commercial injection of 59.30±10.67 min (p<0.05). At the 1 mg/kg dose, the thrombolysis effect of micellar group was stronger than that of the commercial group (p<0.05). In conclusion, TPGS polymer micelles provided a valid strategy in chemotherapy for cerebrovascular diseases with poor water solubility and poor lipid solubility drugs such as scutellarin.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1305-1312
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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