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Tytuł:
Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8
Autorzy:
Wang, Lu
Pan, Xiao
He, Liangqiang
Zhang, Rong
Chen, Wei
Zhang, Jing
Lu, Min
Hua, Zi-Chun
Powiązania:
https://bibliotekanauki.pl/articles/1039602.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
caspase-8
yeast two-hybrid
Vps41
protein interaction
apoptosis
Opis:
Caspase-8 is a member of the cysteine-aspartic acid protease (caspase) family which plays a central role in apoptosis and development. We screened caspase-8 interacting proteins from mouse T-cell lymphoma and 7.5-day embryo cDNA libraries by yeast two-hybrid system and obtained eleven positive clones, including Vacuolar protein sorting 41 (Vps41), a protein involved in trafficking of proteins from the late Golgi to the vacuole. The interaction of Vps41 with caspase-8 was confirmed by co-immunoprecipitation (co-IP) and co-localization studies in HEK293T cells. Co-IP experiments also showed that Vps41 binds to the p18 subunit of caspase-8 through its WD40 region and RING-finger motif. Furthermore, we found that overexpression of Vps41 promotes Fas-induced apoptosis in A549 human lung adenocarcinoma cells. The cleavage of caspase-3, a caspase-8 downstream effector, was increased when cells were transfected with Vps41-overexpressing plasmid. Together, these results suggest a novel interaction of caspase-8 with Vps41 and provide a potential role of Vps41 beyond lysosomal trafficking.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 37-42
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The separation of microscale HA in aqueous solution by foam separation technique
Autorzy:
Wenyao, Shao
Xiao, Gong
Shuming, Cui
Ying, Lin
Yinghua, Lu
Yuqing, Chen
Powiązania:
https://bibliotekanauki.pl/articles/949357.pdf
Data publikacji:
2019
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Foam Separation
Hyaluronic Acid
Enrichment Ratio
Recovery Rate
Opis:
Hyaluronic acid (HA) has important applications in fields of health care products, cosmetics and clinical medical. However, the unique physiological properties of HA make cost of its traditional separation and extraction process relatively high. Foam separation technique has simple, gentle and efficient advantages on the separation of substances with surface activity by using bubbles as the separation medium. In this paper, natural surfactant CocamideBetaine (CAPB) was used as a foaming agent to explore the technology of microscale HA in aqueous solution by foam separation. The optimum process conditions were determined based on the recovery rate and enrichment ratio of HA by single factor and orthogonal experiment: at room temperature, pH = 7, separating air velocity (v) = 350 mL/min, HA concentration (CHA) = 50 mg/L, adding liquid volume (V) = 200 mL, collecting time (tcol) = 10 min, CAPB concentration (CCAPB) = 0.035 g/L. Under these conditions, HA enrichment ratio (E) equals 6.821 and HA recovery rate (R) equals 66.425%.
Źródło:
Polish Journal of Chemical Technology; 2019, 21, 4; 66-71
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The application of E-learning in maritime education and training in China
Autorzy:
Chen, X.
Bai, X.
Xiao, Y.
Powiązania:
https://bibliotekanauki.pl/articles/116574.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Morski w Gdyni. Wydział Nawigacyjny
Tematy:
maritime education and training (MET)
MET System in China
e-Learning
e-Learning training
education system
maritime education
STCW Convention
application of e-Learning
Opis:
E-learning brings the third wave to Internet applications. E-learning is a new training mode with the open characteristics, which is completely different with traditional training. E-learning teaches students the specialized knowledge of theories, work experience and technology by information networks and computer hardware equipment. Students can through a variety of terminal equipment to learn anytime and anywhere, so as to improve student learning results. Maritime education and training must conform to the trend of times to explore E-learning training to improve the training performance. In this paper, based on the theory of E-learning, comparing the advantages and disadvantages of E-learning training. By analyzing current status of maritime education and training, using E-learning to establish China's maritime education and training of the lifelong education system, using E-learning to promote the internationalization of navigation education and training.
Źródło:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation; 2017, 11, 2; 349-354
2083-6473
2083-6481
Pojawia się w:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface modification of fly ash spheroidal particles and their application in the adsorption of phosphorus and chromium(VI) from single and competitive solute systems
Autorzy:
Chen, Chen
Cheng, Ting
Zhang, Xiao
Zhang, Minte
Lv, Ruiyang
Powiązania:
https://bibliotekanauki.pl/articles/2032957.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
fly ash
Langmuir isotherm
adsorption phosphorus
popiół lotny
izoterma Langmuira
adsorpcja fosforu
Opis:
This work focuses on the surface modification of fly ash spheroidal particles and their application in phosphorus and chromium(VI) adsorption. The results show that through surface modification, amorphous silica-alumina gels precipitated on the spheroidal particle surface (by which the microsurface area of the reaction products is effectively enlarged) and the surface zeta potential was changed to fit for adsorbing anions. During the adsorption experiment (single and competitive solute systems), chromium(VI) was easier to adsorb. The surface zeta potential and the existence of competitive ions should be recognized as two important factors affecting adsorption efficiency. A higher temperature could improve the adsorption efficiencies of the two solute systems. The fitting results of the pseudo-second-order model (single and competitive solute systems) show better agreement than those of the pseudo-first-order model at every temperature. The Langmuir adsorption isotherm equation can better simulate the adsorption process in single solute sy039stems, but only the chromium(VI) adsorption process can be fitted by the competitive Langmuir adsorption isotherm in competitive solute systems.
Źródło:
Environment Protection Engineering; 2020, 46, 3; 39-59
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on separation of fine-particle ilmenite and mechanism using flocculation flotation with sodium oleate and polyacrylamide
Autorzy:
Peng, Yang
Xiao, Junhui
Deng, Bing
Wang, Zhen
Liu, Nengyun
Yang, Daoguang
Ding, Wei
Chen, Tao
Wu, Qiang
Powiązania:
https://bibliotekanauki.pl/articles/1450088.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
sodium oleate
polyacrylamide
synergistic effect
ilmenite
flocculation flotation
Opis:
In this paper, sodium oleate, polyacrylamide, soluble starch and sodium carboxymethyl cellulose were used as flocculants to study the flocculation and sedimentation behavior of microfine ilmenite. Sedimentation test shows that sodium oleate and polyacrylamide have good flocculation effect on ultrafine ilmenite. The flocculation rate of ilmenite can be further improved by the combination of sodium oleate and polyacrylamide. It was found that both flocculants could generate chemical adsorption with ilmenite surface, and they all react with $Fe^{3+}$ on ilmenite surface. However, sodium oleate reacts with $Fe^{3+}$ to form a water-insoluble iron oleate precipitate which coats the surface of the ilmenite and hinders the action of polyacrylamide and the remaining $Fe^{3+}$. This problem can be avoided by adding polyacrylamide followed by sodium oleate, and the flotation recovery can be increased significantly.
Źródło:
Physicochemical Problems of Mineral Processing; 2020, 56, 1; 161-172
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stress evolution mechanism and thermo-mechanical reliability analysis of copper-filled TSV interposer
Autorzy:
Chen, Yuan
Su, Wei
Huang, Hong-Zhong
Lai, Ping
Lin, Xiao-ling
Chen, Si
Powiązania:
https://bibliotekanauki.pl/articles/1841909.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
through silicon vias
thermo-mechanical reliability
failure mechanism
finite element analysis
3D integrated packaging
thermal cycling experiment
Opis:
Through silicon via (TSV) has become one of the key emerging trends of three-dimensional (3D) packages, as it can realize vertically interconnect between stacked-dies. Due to large mismatch in thermal expansion coefficients (CTE) between the copper via and the silicon, significant mechanical stresses are induced at the interfaces when TSV structure is subjected to thermal stresses, which would greatly affect the reliability and electrical performance of TSV 3D device. In this paper, the relationship between the state of stresses and failure of TSV had been explored by combining finite element model simulation (FEM) and failure physical analysis. The position of the maximum stress of the TSV structure was obtained by FEM analysis. The relationship of stress and displacement change with temperature was also studied. And a thermal cycling experiment was conducted to validate the simulation results. Physical failure analysis after thermal cycling experiment was used to verify the degradation mechanism predicted by thermo-mechanical simulation.
Źródło:
Eksploatacja i Niezawodność; 2020, 22, 4; 705-714
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on the Optical and EPR Spectral Data and the Local Structure for the Tetragonal $Nb^{4+}$ Center in Glasses
Autorzy:
Wu, Xiao-Xuan
Yu, Xin-Peng
Zheng, Wen-Chen
Powiązania:
https://bibliotekanauki.pl/articles/1402323.pdf
Data publikacji:
2015-07
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
76.30.He
71.70.Ch
78.40.Pg
78.55.Qr
Opis:
Two optical bands and four EPR (or spin-Hamiltonian) parameters (g factors $g_{∥}$, $g_{⊥}$ and hyperfine structure constants $A_{∥}$, $A_{⊥}$) of the tetragonally-compressed $Nb^{4+}$ octahedral center in glasses are calculated from two methods, the complete diagonalization (of energy matrix) method and the perturbation theory method. Both methods are founded on the two-spin-orbit-parameter model where both the contribution to the spectral data from the spin-orbit parameter of central $d^{n}$ ion and that of ligand ion via covalence effect are considered. The calculated results from both the complete diagonalization (of energy matrix) method and perturbation theory method show reasonable agreement with the experimental values. The signs and possible misprint for the observed hyperfine structure constants $A_{∥}$ and $A_{⊥}$ are suggested, and the local structure of the tetragonal $Nb^{4+}$ center in glasses due to the Jahn-Teller effect is gained from the calculations. The results are discussed.
Źródło:
Acta Physica Polonica A; 2015, 128, 1; 72-75
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on optimal design of vibration reduction of centrifugal air conditioning chiller based on particle damping
Autorzy:
Xiao, Wangqiang
Shi, Jinsong
Chen, Hui
Liu, Hua
Powiązania:
https://bibliotekanauki.pl/articles/2200880.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
centrifugal air-conditioning chiller
particle damping
DEM
vibration reduction
optimal scheme
Opis:
Considering vibration of centrifugal air-conditioning chillers at working conditions of 300Hz and 386Hz, a vibration reduction method for centrifugal air-conditioning chillers based on particle damping is proposed. Firstly, the vibration transfer path of the chillers is determined based on dynamic characteristics analysis of the chillers. Secondly, the vibration sensitive area of the compressor is determined by finite element analysis. Then the energy dissipation is calculated by the discrete element method (DEM) to determine the optimal installation scheme of the damper. Finally, the vibration reduction effect of the chillers after arranging the damper is verified by experiments.
Źródło:
Journal of Theoretical and Applied Mechanics; 2023, 61, 1; 189--201
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary results of spatial distribution of uranium and thorium in soil profi les near a uranium industrial site, Guangdong province, China
Autorzy:
Wang, J.
Liu, J.
Chen, Y.
Song, G.
Chen, D.
Xiao, T.
Li, H.
Wang, C.
Jiang, F.
Powiązania:
https://bibliotekanauki.pl/articles/146530.pdf
Data publikacji:
2016
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
spatial distribution
thorium
uranium
U/Th ratio
Opis:
Four soil profiles were collected from locations with different distances (5, 50, 250 and 1000 m) from a uranium mill tailings dam, Guangdong province, China, to investigate the pollution status of the soil in mining/ milling-related areas based on the contents of uranium (U) and thorium (Th), thus to understand the impacts of uranium industrial activities to the surroundings. The U and Th concentrations were determined by inductively coupled plasma mass spectrometry (ICP-MS) after conventional HF-HNO3-HClO4 digestion procedures. The results indicate that the soils within 50 m from uranium tailing were severely contaminated; those in 250 and 1000 m soil samples were observed to be with local background level even though these in 250 m had slightly higher U/Th ratios. Uranium concentrations varied from 5.50 ± 0.27 to 160.55 ± 8.03 mg/kg, with maximum values recorded in an intermediate layer of the 5-m distance soil profile. In comparison, the concentration of Th ranged from 6.02 ± 0.30 to 84.71 ± 4.24 mg/kg, with maximum values observed in the top layer of the 1000-m distance soil profile. The U/Th ratio varied from 0.15 to 11.99 compared with 0.20, 0.22 and 0.26 of the average for Guangdong province, national China and the world, respectively. The mean U/Th of four soil profiles showed a reduction with distance from the uranium mill tailing dam, suggesting the relatively large magnitude of uranium elevation in soils within limited distances.
Źródło:
Nukleonika; 2016, 61, 3; 367-371
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:
Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Powiązania:
https://bibliotekanauki.pl/articles/1039743.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Opis:
Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 249-254
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Joint optimization of replacement and spare ordering for critical rotary component based on condition signal to date
Wspólna optymalizacja wymiany i zamawiania części zamiennych dla krytycznego komponentu obrotowego na podstawie dotychczasowego sygnału stanu
Autorzy:
Chen, X.
Xu, D.
Xiao, L.
Powiązania:
https://bibliotekanauki.pl/articles/301404.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
prognozowanie degradacji
degradation prediction
failure probability
condition-based replacement
spare part ordering
prawdopodobieństwo wystąpienia uszkodzenia
wymiana w oparciu o stan
zamawianie części zamiennych
Opis:
It is widely accepted that condition-based replacement can not only make full use of components, but also decline inventory cost if the procurement of spare parts can be triggered upon accurate failure prediction. Most of the existing degradation or failure prediction models and approaches are population-based failures or suspensions, namely, to predict the failure time of a component, there are some failure or suspension histories of same type or similar components which can be used as reference. However, in practice, there exists the phenomenon in which no failure or suspension histories for some components can be used, what can be utilized is just the collected condition monitoring signals to date. In that case, failure time and probability are difficult to be estimated accurately. In this paper, a novel degradation prediction approach is introduced. Meantime, a new failure probability estimation function is developed based on component “service time” and “degradation extent” simultaneously. Then replacement and spare part ordering are jointly optimized according to the estimated failure probability. The optimization objective is to minimize long-run cost rate. Two bearing datasets are used to validate the proposed approach.
Powszechnie przyjmuje się, że wymiana w oparciu o stan techniczny pozwala nie tylko na pełne wykorzystanie elementów składowych, ale także na zmniejszenie kosztów magazynowych (związanych z przechowywaniem zapasów) jeśli zamawianie części zamiennych da się powiązać z trafnym prognozowaniem uszkodzeń. Większość istniejących modeli i teorii predykcji degradacji lub uszkodzeń opiera się na danych populacyjnych o uszkodzeniach lub zawieszeniu pracy co oznacza, że czas uszkodzenia komponentu przewiduje się w odniesieniu do historii uszkodzeń lub zawieszeń pracy tego samego typu lub podobnego typu elementów składowych. Jednak w praktyce zdarza się, że dla niektórych komponentów nie istnieją historie uszkodzeń lub zawieszenia pracy, do których można by się odnieść; jedyne co można wykorzystać to zgromadzone dotychczas sygnały z monitorowania stanu. W takim przypadku, trudno jest ocenić dokładnie czas i prawdopodobieństwo wystąpienia uszkodzenia. W niniejszej pracy, przedstawiono nowatorskie podejście do przewidywania degradacji. Opracowano nową funkcję szacowania prawdopodobieństwa uszkodzenia opartą na jednoczesnym wykorzystaniu "czasu pracy" oraz "stopnia degradacji" komponentu. Następnie wspólnie zoptymalizowano procesy wymiany i zamawiania części zamiennych zgodnie z szacowanym prawdopodobieństwem wystąpienia uszkodzenia. Celem optymalizacji była minimalizacja długoterminowego wskaźnika kosztów . Poprawność proponowanego podejścia zweryfikowano z wykorzystaniem dwóch zbiorów danych dotyczących łożysk.
Źródło:
Eksploatacja i Niezawodność; 2017, 19, 1; 76-85
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hereditary Equality of Domination and Exponential Domination in Subcubic Graphs
Autorzy:
Chen, Xue-Gang
Wang, Yu-Feng
Wu, Xiao-Fei
Powiązania:
https://bibliotekanauki.pl/articles/32324524.pdf
Data publikacji:
2021-11-01
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
dominating set
exponential dominating set
subcubic graphs
Opis:
Let γ(G) and γe(G) denote the domination number and exponential domination number of graph G, respectively. Henning et al., in [Hereditary equality of domination and exponential domination, Discuss. Math. Graph Theory 38 (2018) 275–285] gave a conjecture: There is a finite set ℱ of graphs such that a graph G satisfies (H) = γe(H) for every induced subgraph H of G if and only if G is ℱ-free. In this paper, we study the conjecture for subcubic graphs. We characterize the class ℱ by minimal forbidden induced subgraphs and prove that the conjecture holds for subcubic graphs.
Źródło:
Discussiones Mathematicae Graph Theory; 2021, 41, 4; 1067-1075
2083-5892
Pojawia się w:
Discussiones Mathematicae Graph Theory
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flotation separation of rutile from almandine using octadecyl amine polyoxyethylene ether as collector
Autorzy:
Li, Hongqiang
Zheng, Huifang
Chen, Qian
Kasomo, Richard M.
Leng, Jiahao
Weng, Xiaoqing
Song, Shaoxian
Xiao, Linbo
Tian, Chengtao
Powiązania:
https://bibliotekanauki.pl/articles/1449410.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
rutile
almandine
flotation separation
adsorption mechanism
Opis:
In this study, the flotation separation of rutile from almandine using cationic surfactant Octadecyl amine polyoxyethylene ether (AC1815) as a new collector was investigated. The adsorption mechanism of AC1815 on rutile was illustrated through zeta potential measurement, infrared spectrum and XPS analyses. The flotation experiments demonstrated that AC1815 exhibited an excellent collecting ability and selectivity for rutile. The results of zeta potential measurements and XPS analysis indicated that more AC1815 was adsorbed on rutile surface instead of almandine. The adsorption mechanism of AC1815on rutile was mainly attributed to the electrostatic interaction between the positively charged molecules of AC1815 and the negatively charged rutile surface, and the hydrogen bonding between the protonated $≡NH^+$, $≡N$ group of AC1815 and $Ti-OH$ on rutile surface.
Źródło:
Physicochemical Problems of Mineral Processing; 2020, 56, 4; 653-664
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Feasibility study on preparation of magnesium titanate in carbonthermic reduction of vanadium titanomagnetite concentrates
Autorzy:
Chen, Chao
Sun, Ti-Chang
Kou, Jue
Wang, Xiao-Ping
Zhao, Yong-Qiang
Powiązania:
https://bibliotekanauki.pl/articles/110181.pdf
Data publikacji:
2019
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
vanadium titanomagnetite
carbonthermic reduction
magnesium titanate
formation mechanism
Opis:
Effect of temperature and Mg:Ti ratio on phase composition and microstructure of reduced pellets was investigated to verify the feasibility of preparation of magnesium titanate by adding MgO in carbonthermic reduction of the vanadium titanomagnetite concentrates (VTC). Thermodynamic analysis results showed that magnesium titanate is more easily generated than FeTi2O5 or TiO2 by the reaction of FeTiO3 and MgO under the reductive atmosphere, which was confirmed by the discovery of magnesium titanate at roast experiment. It was found that the optimum conditions for reduction of VTC pellets were temperature of 1250 ºC and Mg:Ti ratio of 2, and the main phases of reduction product were metallic Fe and magnesium titanate (Mg2TiO4). However, trace iron impurities in Mg2TiO4 particles were found by energy-dispersive spectroscopy (EDS), so further purification is required.
Źródło:
Physicochemical Problems of Mineral Processing; 2019, 55, 2; 417-425
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
Autorzy:
Li, Xiao-Xing
Zhao, Lang
Chang, Ying
Liu, Bao-Shan
Xu, Feng
Zhang, Cheng
Ji, Xiao-Ping
Chen, Yu-Guo
Li, Chuan-Bao
Powiązania:
https://bibliotekanauki.pl/articles/1038380.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
obese
inflammation
remodeling
ezetimibe
IL-6
Opis:
Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 465-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 30

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