Autor: Chen, Chuan - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:: Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Powiązania:: https://bibliotekanauki.pl/articles/1039743.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Opis:: Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Źródło:: Acta Biochimica Polonica; 2012, 59, 2; 249-254
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
Autorzy:: Li, Xiao-Xing
Zhao, Lang
Chang, Ying
Liu, Bao-Shan
Xu, Feng
Zhang, Cheng
Ji, Xiao-Ping
Chen, Yu-Guo
Li, Chuan-Bao
Powiązania:: https://bibliotekanauki.pl/articles/1038380.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: obese
inflammation
remodeling
ezetimibe
IL-6
Opis:: Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 465-470
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Influence of grouting pressure volatility on additional response of adjacent pile foundation in shield construction
Autorzy:: Zhang, Chuan-Chuan
Li, Dan-Mei
Zhang, Jun
Yu, Tong-Sheng
Chen, Qiang
Powiązania:: https://bibliotekanauki.pl/articles/2086958.pdf
Data publikacji:: 2022
Wydawca:: Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:: grouting pressure fluctuations
adjacent loaded-pile foundation
normal distribution
FLAC3D
Opis:: Soil parameters along the heading direction are subjected to spatial variability during shield construction, so grouting pressure requires constant adjustment to ensure ground stress sta- bility. This causes grouting pressure to fluctuate around the design pressure/curve. There- fore, the influence of the grouting pressure volatility on the adjacent loaded-pile foundation should be considered in shield tunneling. In this study, a refined numerical simulation of the shield construction process is conducted using the Fast Lagrangian Analysis of Continua in Three Dimensions (FLAC3D) software. A total of 300 groups of grouting pressure pa- rameters with a skewed normal distribution are input into the numerical model. Then, the influence of the construction parameter uncertainty on the adjacent loaded-pile foundation is analyzed. Finally, the back analysis method is conducted based on the monitored data to evaluate how the construction process affects the pile foundation. The calculation results are compared with those of the traditional finite element method. The results indicate that in the tunneling process, the grouting pressure fluctuation greatly affects the additional bend- ing moment of the adjacent pile foundation. Under the influence of the grouting pressure, the additional axial force and additional bending moment of the pile foundation also follow the skewed normal distribution. The back analysis results of the pile foundation are greater than those of the typical numerical method by about 60% 100%, that is using the back analysis calculation results to evaluate the pile foundation additional response can reduce the risk.
Źródło:: Journal of Theoretical and Applied Mechanics; 2022, 60, 1; 33--47
1429-2955
Pojawia się w:: Journal of Theoretical and Applied Mechanics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: An extrinsic Fabry–Pérot interference fiber sensor for ultrasonic detection of partial discharge
Autorzy:: Zhang, Ximin
Qian, Sen
Liu, Huixin
Chen, Chuan
Deng, Chuanlu
Hu, Chengyong
Huang, Yi
Powiązania:: https://bibliotekanauki.pl/articles/27310090.pdf
Data publikacji:: 2023
Wydawca:: Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:: extrinsic Fabry-Pérot interference
fibre sensor
partial discharge
sensitivity
frequency
Opis:: An ultrasonic sensor based on extrinsic Fabry–Pérot interference (EFPI) has been designed and demonstrated to detect the ultrasonic wave signal. The sensitivity and natural frequency of fiber Fabry–Pérot (F-P) sensor with different structure parameter have been simulated by COMSOL. The simulation results illustrate that the sensitivity is up to 1.737 nm/kPa and the natural frequency is 2.1 MHz, when the silica diaphragm thickness is 2 μm, the radius is 90 μm, and the cavity length is 18 μm. The most suitable parameters have been selected and the F-P sensor has been fabricated. When the ultrasonic signals with the frequencies of 40 kHz and 1.2 MHz are respectively applied to the sensor, the frequencies detected by the EFPI ultrasonic sensor are 39 kHz and 1.21 MHz based on a partial discharge detection experiment for the designed demodulation system. The experimental results show that the sensor can accurately detect ultrasonic signals. As an excellent platform for ultrasonic signal sensing, this EFPI ultrasonic sensing system has great potential applications in partial discharge detection field.
Źródło:: Optica Applicata; 2023, 53, 2; 199--211
0078-5466
1899-7015
Pojawia się w:: Optica Applicata
Dostawca treści:: Biblioteka Nauki

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