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Wyszukujesz frazę "Cheda, A." wg kryterium: Autor

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    Wyświetlanie 1-4 z 4
    Tytuł:
    Stimulatory effects of single low-level irradiations with X-rays on functions of murine peritoneal macrophages
    Autorzy:
    Cheda, A.
    Wrembel-Wargocka, J.
    Nowosielska, E.
    Janiak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/147798.pdf
    Data publikacji:
    2005
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    low doses
    X-rays
    macrophages
    nitric oxide
    cytotoxicity
    TNF-alfa
    Opis:
    A number of epidemiological and experimental data indicate that exposures to low doses of low-LET ionising radiation may trigger the activity of natural anti-tumour immune mechanisms and inhibit tumour growth. In the present study, we assessed the cytotoxic activity and production of nitric oxide, superoxide anions, and tumour necrosis factor-alfa in peritoneal macrophages collected from BALB/c mice exposed to single whole-body irradiations with 0.1, 0.2, or 1.0 Gy X-rays. The results indicate that all the tested parameters were significantly up-regulated in macrophages obtained from mice exposed to 0.1 or 0.2 Gy X-rays but not in those collected from the sham-irradiated and 1.0 Gy-exposed animals.
    Źródło:
    Nukleonika; 2005, 50,suppl.2; 13-16
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low-level exposures to ionising radiation modulate the anti-tumour activity of murine NK cells
    Autorzy:
    Nowosielska, E.
    Wrembel-Wargocka, J.
    Cheda, A.
    Lisiak, E.
    Janiak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/147802.pdf
    Data publikacji:
    2005
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    low doses
    X-rays
    NK cells
    cytotoxicity
    anti-asialo GM1 antibody
    FasL
    Opis:
    Experimental evidence from the recent years indicates that low-level irradiations with X- or gamma rays may inhibit development of both primary and secondary tumours and stimulate the activity of natural anti-tumour immune mechanisms. Natural killer (NK) cells play an important role in anti-tumour defence of the host. In the present investigation cytotoxic activity, production of interferon-ă, and expression of the Fas ligand (FasL) were estimated in the NK splenocytes collected from BALB/c mice whose whole body was pre-exposed to irradiation with 0.1, 0.2, or 1.0 Gy X-rays. The results indicate that cytotoxic activity of the irradiated NK cells was significantly stimulated compared to that of the NK effectors obtained from the sham-exposed mice. This effect was totally abrogated by injection of the anti-asialo GM1 antibody. In addition, compared to the control mice, NK cells obtained from the irradiated animals exhibited reduced surface expression of FasL. Collectively, the obtained results suggest that the inhibitory effect of the low-level irradiations with X-rays on the development of pulmonary tumour nodules may be directly associated with stimulation by such exposures of anti-neoplastic functions mediated by NK cells.
    Źródło:
    Nukleonika; 2005, 50,suppl.2; 21-24
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modulation of the growth of pulmonary tumour colonies in mice after single or fractionated low-level irradiations with X-rays
    Autorzy:
    Nowosielska, E. M.
    Cheda, A.
    Wrembel-Wargocka, J.
    Janiak, M. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/147682.pdf
    Data publikacji:
    2008
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    low-level X-rays
    NK cells
    macrophages
    tumour colonies
    anti-neoplastic activity
    Opis:
    A number of epidemiological and experimental data indicate that exposures to low doses of low-LET ionizing radiation may trigger the activity of natural anti-tumour immune mechanisms and inhibit tumour growth. Natural killer (NK) cells and activated macrophages play important roles in the anti-tumour defence of the host. In view of this, the aim of the present study was to correlate the tumour-inhibitory effect of low doses of X-rays with the activities of NK cells and macrophages. BALB/c mice were whole-body irradiated with single or fractionated doses of 0.1, 0.2, or 1.0 Gy X-rays and then intravenously injected with L1 sarcoma cells; 14 days later, tumour colonies on the lungs' surface were counted. Cytotoxic activities of NK cells and macrophages were estimated using the 51Cr-release and [3H]thymidineuptake assays, respectively. The anti-asialo GM1 antibody and carrageenan (CGN) were intraperitoneally injected to block the NK cell- and macrophage-mediated activities in vivo, respectively. Single and fractionated whole-body irradiation (WBI) of mice with 0.1 or 0.2 Gy X-rays led to reduction in the number of the pulmonary tumour colonies accompanied by the enhanced cytotoxic activities of both NK lymphocytes and macrophages. Treatment of mice with anti-asialo GM1 antibody or CGN abrogated the tumour-inhibitory effects of the low-level exposures to X-rays. The obtained data suggest that suppression of the development of pulmonary tumour colonies by single or fractionated irradiations of mice with the low doses of X-rays may result from stimulation of the natural anti-tumour defence reactions mediated by NK cells and/or cytotoxic macrophages.
    Źródło:
    Nukleonika; 2008, 53, suppl. 1; 9-15
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging of hypoxia in small animals with 18F fluoromisonidasole
    Autorzy:
    Kilian, K.
    Rogulski, Z.
    Cheda, Ł.
    Drzał, A.
    Gerszewska, M.
    Cudny, M.
    Elas, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/148618.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    18F-fluoromisonidazole
    radiopharmaceuticals
    hypoxia imaging
    Opis:
    A method of automated synthesis of [18F]fluoromisonidazole ([18F]FMISO) for application in preclinical studies on small animals was presented. A remote-controlled synthesizer Synthra RNplus was used for nucleophilic substitution of NITTP (1-(2'-nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonyl-propanediol) with 18F anion. Labeling of 5 mg of precursor was performed in anhydrous acetonitrile at 100°C for 10 min, and the hydrolysis with HCl was performed at 100°C for 5 min. Final purifi cation was done with high-performance liquid chromatography (HPLC) and the radiochemical purity of radiotracer was higher than 99%. Proposed [18F]FMISO synthesis was used as a reliable tool in studies on hypoxia in Lewis lung carcinoma (LLC) in mouse models.
    Źródło:
    Nukleonika; 2016, 61, 2; 119-223
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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