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    Wyświetlanie 1-9 z 9
    Tytuł:
    Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma
    Autorzy:
    Cabaj, J.
    Bak, W.
    Wroblewska-Luczka, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098520.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    neoplastic disease
    melanoma
    skin cancer
    cancer therapy
    anticancer effect
    triterpene
    betulin
    betulic acid
    Opis:
    Introduction. Neoplastic diseases are a common cause of death, especially in developed countries. Various methods are used in cancer therapy including natural substances. Terpenes and terpenoids play a special role, including betulin and betulinic acid with the pentacyclic structure of lupane. They have a wide range of pharmacological activity, among which anti-cancer activity attracts the greatest attention. Abbreviated description of the state of knowledge. The review discusses the pharmacological effects of betulin and its derivatives on tumours, and focuses on the potential of its application in the treatment of melanoma. The review study also presents future prospects for the use of this natural substance. Betulin and its derivatives have the ability to influence the processes of apoptosis, angiogenesis and autophagy. Additionally, they have the ability to sensitize, increasing the sensitivity to commonly used methods of cancer treatment. To-date, numerous studies have been carried out on the synthesis of betulinic acid derivatives, which would show greater polarity and activity compared to the starting compound. Due to their greater bioavailability, the modified compounds showed a stronger anti-tumour effect. Conclusion. The results of the above-mentioned studies confirm the anti-cancer properties of betulin. Regarding melanoma, betulin shows significant therapeutic efficacy. This gives new perspectives for the treatment of the most dangerous skin cancer.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 2; 73-79
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of crizotinib therapy for a patient with non-small cell lung cancer with ALK gene rearrangement – case report and review of current therapeutic options
    Autorzy:
    Bargiel, J.B.
    Cabaj, J.
    Chmielewska, I.
    Milanowski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2098542.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    non-small cell lung cancer
    crizotinib
    therapy
    gene rearrangement
    tyrosine kinase inhibitor
    patient
    Opis:
    Introduction. Currently, nearly 23,000 cases of lung cancer are diagnosed in Poland annually, of which 5% are cases with rearrangements in the ALK gene. In recent years, tremendous progress has been made in understanding the genetic makeup of this type of cancer, which has enabled the use of new therapies, in particular, molecularly targeted drugs. Crizotinib is the first oral small molecule inhibitor of ALK, MET and ROS1 receptor tyrosine Kinases approved by the European Medicines Agency(EMA). Case report. The paper presents the case of a 62-year-old patient diagnosed with non-small cell lung cancer with rearrangement in the ALK gene in stage IV of the disease. The patient was qualified for treatment with crizotinib under the B6 drug programme. Treatment started in May 2019. During treatment, assessment was made at 3 control points, where the first and second showed a partial response according to the RECIST 1.1 scale; in the next assessment, the response was maintained in the form of disease stabilization.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2021, 15, 3; 151-154
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fallow deer (Dama dama) as a new intermediate host for Sarcocystis cruzi
    Autorzy:
    Bien, J.
    Gozdzik, K.
    Moskwa, B.
    Cabaj, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/6361.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    fallow deer
    Dama dama
    new host
    Sarcocystis cruzi
    protozoan parasite
    parasite
    animal parasite
    Źródło:
    Annals of Parasitology; 2016, 62, Suppl.
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Heterotrophic bacteria from brackish water of the Southern Baltic Sea: biochemical and molecular identification and characterisation
    Autorzy:
    Cabaj, A.
    Palinska, K.
    Kosakowska, A.
    Kurlenda, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/48857.pdf
    Data publikacji:
    2006
    Wydawca:
    Polska Akademia Nauk. Instytut Oceanologii PAN
    Tematy:
    molecular identification
    surface water
    biochemical identification
    rDNA sequence analysis
    Baltic Sea
    Bacillaceae
    brackish water
    heterotrophic bacteria
    Opis:
    Six bacterial strains isolated from the surface water of the southern Baltic Sea were described on the basis of their morphological, physiological and biochemical features, and were classified on the basis of 16S rDNA sequence analysis. Comparative analyses of the 16S rDNA sequences of five of the six bacterial strains examined displayed a ≥98% similarity to the sequences available in the NCBI GenBank. The 16S rDNA sequence of strain 2 shared only a 96% similarity with other published sequences, which suggests that this is a new, hitherto unknown species. The isolated heterotrophic bacteria belong to the families Bacillaceae (strain 1), Flexibacteriaceae (strain 2), Sphingomonadaceae (strains 3, 5), Micrococcaceae (strain 4) and Aurantimonadaceae (strain 6). This is the first study in which the polyphasic approach has been applied to the identification of heterotrophic bacteria from the brackish waters of the Gulf of Gdańsk and Gdańsk Deep.
    Źródło:
    Oceanologia; 2006, 48, 4
    0078-3234
    Pojawia się w:
    Oceanologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neurotransmitters detection using a fluorescence-based sensor with graphene quantum dots
    Autorzy:
    Baluta, S.
    Cabaj, J.
    Malecha, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/175014.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    sensor
    dopamine
    fluorescence
    Förster resonance energy transfer
    quantum dots
    Opis:
    In the paper, the development and performance of an optical sensor for detection of neurotransmitters (dopamine) is presented. The concentration of dopamine is measured basing on fluorescence quenching of graphene quantum dots. In the sensor, the dopamine molecules coat the graphene quantum dots surface – in result, the quenching of fluorescence occurs due to the Förster resonance energy transfer. The changes in fluorescence correspond to specific concentrations of the neurotransmitter in tested samples, so it is possible to accurately determine the concentration of dopamine in the sample.
    Źródło:
    Optica Applicata; 2017, 47, 2; 225-231
    0078-5466
    1899-7015
    Pojawia się w:
    Optica Applicata
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Serological monitoring of Toxoplasma gondii and Neospora caninum in sheep, goats and fallow deer farmed together on the same area
    Autorzy:
    Moskwa, B.
    Kornacka, A.
    Cybulska, A.
    Cabaj, W.
    Bogdaszewski, M.
    Bogdaszewska, Z.
    Reiterova, K.
    Justyna Bien, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/6373.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    serological monitoring
    parasite
    Toxoplasma gondii
    Neospora caninum
    sheep
    goat
    fallow deer
    farm
    Źródło:
    Annals of Parasitology; 2016, 62, Suppl.
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Seroprevalence of Neospora caninum in free living and farmed red deer [Cervus elaphus] in Poland
    Autorzy:
    Gozdzik, K
    Jakubek, E.B.
    Bjorkman, C.
    Bien, J.
    Moskwa, B.
    Cabaj, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/32072.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Polska
    free living red deer
    farmed red deer
    red deer
    Cervus elaphus
    seroprevalence
    Neospora caninum
    ELISA test
    immunoblot
    animal disease
    animal infection
    Opis:
    Serum samples from 47 free living and 106 farmed red deer (Cervus elaphus) from the Mazurian Lake District in north-east Poland were investigated for the presence of antibodies to Neospora caninum. A modified Neospora iscom-ELISA was used for initial screening. All sera with optical density (OD) values exceeding 0.400 absorbance units were further investigated by Western blot analysis. Eighteen sera were positive in both tests. Six of these were from free living and 12 from farmed animals giving prevalence of 13 and 11%, respectively. This is the first report of N. caninum infection in farmed and free-living red deer living in the same region where neosporosis was confirmed in cattle and the first evidence of exposure to the parasite in red deer in Poland.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 1; 117-120
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The estimation of different ELISA procedures for serodiagnosis of human trichinellosis
    Autorzy:
    Moskwa, B.
    Bień, J.
    Cabaj, W.
    Korinkova, K.
    Koudela, B.
    Kacprzak, E.
    Stefaniak, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2144348.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    parasite
    human disease
    serodiagnosis
    diagnosis
    trichinellosis
    ELISA test
    zoonotic disease
    ELISA procedure
    excretory-secretory antigen
    Trichinella spiralis
    human outbreak
    Opis:
    Introduction. The most important confirmative diagnostic test for trichinellosis is the presence of the muscle larvae in a tissue biopsy but this direct method has a low sensitivity of light and moderate infections. The aim of presented study was to compare the usefulness of the results obtained by three ELISA procedures for Trichinella spp. diagnosis in human outbreaks. Materials and methods. All sera (cases and controls) were tested for anti-Trichinella antibodies (immunoglobulin G) using commercially available Novatec KIT and two other ELISA procedures based on excretory-secretory (ES) antigens on Trichinella spiralis muscle larvae. The main differences in ELISA procedures were: the protein concentration in antigen, dilution of human serum samples, conjugate and the time of conjugate incubation. Additional differences were noticed in ES antigen preparation procedures as well as in T. spiralis isolates used in these procedures. Serum samples were obtained from 22 symptomatical patients from Poznań region (West Poland), geographic area where human outbreak had occurred. Control serum samples were obtained from 20 patients from an open population from a non endemic trichinellosis area. Results. The results were analyzed in terms of both: statistical and epidemiological point of view. Linear regression analysis and correlations coefficient r between OD values of total 22 patients obtained in three ELISA procedures were positive and high statistically significant. Three ELISA procedures revealed different cut-off values and positivity rates for outbreak. However, the majority of positive samples were found as positive in three procedures, but some of them were positive in two or one procedure only. These individual variability in sera reactivity observed in three ELISA procedures could be very important from epidemiological point of view.
    Źródło:
    Wiadomości Parazytologiczne; 2006, 52, 3; 231-238
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The estimation of different ELISA procedures for serodiagnosis of human trichinellosis
    Autorzy:
    Moskwa, B
    Bien, J.
    Cabaj, W.
    Korinkova, K.
    Koudela, B.
    Kacprzak, E.
    Stefaniak, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/839966.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    parasite
    human disease
    serodiagnosis
    diagnosis
    trichinellosis
    ELISA test
    zoonotic disease
    ELISA procedure
    excretory-secretory antigen
    Trichinella spiralis
    human outbreak
    Opis:
    Introduction. The most important confirmative diagnostic test for trichinellosis is the presence of the muscle larvae in a tissue biopsy but this direct method has a low sensitivity of light and moderate infections. The aim of presented study was to compare the usefulness of the results obtained by three ELISA procedures for Trichinella spp. diagnosis in human outbreaks. Materials and methods. All sera (cases and controls) were tested for anti-Trichinella antibodies (immunoglobulin G) using commercially available Novatec KIT and two other ELISA procedures based on excretory-secretory (ES) antigens on Trichinella spiralis muscle larvae. The main differences in ELISA procedures were: the protein concentration in antigen, dilution of human serum samples, conjugate and the time of conjugate incubation. Additional differences were noticed in ES antigen preparation procedures as well as in T. spiralis isolates used in these procedures. Serum samples were obtained from 22 symptomatical patients from Poznań region (West Poland), geographic area where human outbreak had occurred. Control serum samples were obtained from 20 patients from an open population from a non endemic trichinellosis area. Results. The results were analyzed in terms of both: statistical and epidemiological point of view. Linear regression analysis and correlations coefficient r between OD values of total 22 patients obtained in three ELISA procedures were positive and high statistically significant. Three ELISA procedures revealed different cut-off values and positivity rates for outbreak. However, the majority of positive samples were found as positive in three procedures, but some of them were positive in two or one procedure only. These individual variability in sera reactivity observed in three ELISA procedures could be very important from epidemiological point of view.
    Źródło:
    Annals of Parasitology; 2006, 52, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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